Extending the clinical reach of MRI scanning through innovative low-field engineering and hyperpolarised xenon technology
通过创新的低场工程和超极化氙气技术扩展 MRI 扫描的临床范围
基本信息
- 批准号:EP/X025187/1
- 负责人:
- 金额:$ 127.63万
- 依托单位:
- 依托单位国家:英国
- 项目类别:Research Grant
- 财政年份:2023
- 资助国家:英国
- 起止时间:2023 至 无数据
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
Most magnetic resonance imaging (MRI) scanners used in hospitals operate at a magnetic field strength of either 1.5T or 3T. Research scanners used for advanced imaging applications can have a magnetic field of 7T or higher. However, the build, installation and running costs of these "high field" imaging systems scales with the magnetic field strength. This limits the accessibility and reach of MRI as a versatile and clinically-useful imaging modality. Recent technological advances in artificial intelligence for high-quality image reconstruction pioneered by GE Healthcare (GEHC) with their AIRTM Recon DL product, alongside radiofrequency coil and scanner system engineering developments, make a strong case to revisit "low-field" MRI; e.g. 0.5T. In parallel, novel technologies - such as hyperpolarised 129Xe gas MRI for the lungs pioneered at the University of Sheffield (UoS) - are poised to help maximise the clinical relevance of low-field MRI by providing information on physiology that cannot be visualised by other imaging modalities. In particular, lung MRI is a field of rapid development that will realise benefits at low field; the recent COVID pandemic has highlighted the real and present clinical need for more sensitive lung imaging technologies.This EPSRC prosperity partnership will take the 12-year strong collaboration between UoS and GEHC to the next level through a synergistic research programme that capitalises on the strengths of both partners. Our programme will focus on two main themes: (i) The development and integration of hardware and software needed to achieve clinically-useful lung MRI on the NHS's most common "high-field" systems. (ii) Research into low-field MRI physics and engineering, and the development of hardware and software to demonstrate high-quality imaging at low-field.The work plan for these themes is divided into several work packages, each of which will be led by a team of dedicated experts from either UoS or GEHC with expertise matched to the specific research goals. In addition, this partnership will support four PhD students (three of whom are GEHC staff) to undertake a unique industry-academia co-supervised PhD programme and deliver on demonstrator projects that are distinct yet highly complementary to our main research goals.
医院使用的大多数磁共振成像(MRI)扫描仪的磁场强度要么为1.5T,要么为3T。用于高级成像应用的研究扫描仪的磁场可以达到7T或更高。然而,这些“高场”成像系统的建造、安装和运行成本随磁场强度的变化而变化。这限制了MRI作为一种多功能和临床有用的成像手段的可及性和可及性。由GE Healthcare(GEHC)及其AIRTM Recon DL产品开创的用于高质量图像重建的人工智能技术的最新进展,以及射频线圈和扫描仪系统工程的开发,为重新审视“低场”磁共振成像提供了强有力的理由;例如0.5T。与此同时,新技术--如谢菲尔德大学(UoS)首创的肺部超极化129Xe气体磁共振成像--正准备通过提供其他成像方式无法可视化的生理学信息,帮助最大限度地提高低场磁共振成像的临床相关性。特别是,肺部MRI是一个快速发展的领域,将在低场下实现好处;最近的COVID大流行突显了对更灵敏的肺部成像技术的真实和当前的临床需求。EPSRC的这一繁荣合作伙伴关系将通过一项利用双方优势的协同研究计划,将UOS和GEHC之间长达12年的强大合作推向新的水平。我们的计划将集中在两个主要主题:(I)开发和集成所需的硬件和软件,以在NHS最常见的“高场”系统上实现临床上有用的肺部MRI。(Ii)研究低场磁共振成像的物理和工程,以及开发硬件和软件,以展示低场成像的高质量。这些主题的工作计划分为几个工作包,每个工作包将由来自UOS或GEHC的专门专家团队领导,他们的专业知识与特定的研究目标相匹配。此外,这一合作伙伴关系将支持四名博士生(其中三名是GEHC工作人员)开展一个独特的产业界和学术界共同监督的博士项目,并提供与我们的主要研究目标截然不同但高度互补的示范项目。
项目成果
期刊论文数量(5)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Deep learning-based synthesis of hyperpolarized gas MRI ventilation from 3D multi-inflation proton MRI
基于深度学习的 3D 多膨胀质子 MRI 合成超极化气体 MRI 通气
- DOI:10.58530/2022/1396
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:Astley J
- 通讯作者:Astley J
129Xe chemical shift mapping in the lungs with 3D density-weighted MRSI
使用 3D 密度加权 MRSI 绘制肺部 129Xe 化学位移图
- DOI:10.58530/2022/1182
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:Norquay G
- 通讯作者:Norquay G
A multi-channel deep learning approach for lung cavity estimation from hyperpolarized gas and proton MRI
一种通过超极化气体和质子 MRI 估计肺腔的多通道深度学习方法
- DOI:10.58530/2022/1395
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:Astley J
- 通讯作者:Astley J
Age, sex and lung volume dependence of 129Xe MRI gas exchange metrics
129Xe MRI 气体交换指标的年龄、性别和肺容量依赖性
- DOI:10.1183/13993003.congress-2023.oa4952
- 发表时间:2023
- 期刊:
- 影响因子:0
- 作者:Collier G
- 通讯作者:Collier G
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James Wild其他文献
Brain energy metabolism in ALS: A phosphorus-31 magnetic resonance spectroscopy study
- DOI:
10.1016/j.jns.2021.119412 - 发表时间:
2021-10-01 - 期刊:
- 影响因子:
- 作者:
Matilde Sassani;James Alix;Christopher Mcdermott;Kathleen Baster;Nigel Hoggard;James Wild;Heather Mortiboys;Pamela Shaw;Iain Wilkinson;Thomas Jenkins - 通讯作者:
Thomas Jenkins
NOVEL METHODS IN THE ASSESSMENT OF AORTIC STENOSIS
- DOI:
10.1016/s0735-1097(20)32311-1 - 发表时间:
2020-03-24 - 期刊:
- 影响因子:
- 作者:
Gareth Archer;Norman Briffa;Ian Hall;James Wild;Pankaj Garg;Ever Grech - 通讯作者:
Ever Grech
ALTERED LEFT VENTRICULAR BLOOD FLOW PATTERN AND KINETIC ENERGY IN PATIENTS UNDERGOING AORTIC VALVE INTERVENTION
- DOI:
10.1016/s0735-1097(20)32390-1 - 发表时间:
2020-03-24 - 期刊:
- 影响因子:
- 作者:
Alaa Elhawaz;Gareth Archer;Pankaj Garg;James Wild;Ian Hall;Ever Grech - 通讯作者:
Ever Grech
James Wild的其他文献
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{{ truncateString('James Wild', 18)}}的其他基金
Modelling the impact of geomagnetically induced currents on UK railways
模拟地磁感应电流对英国铁路的影响
- 批准号:
NE/Y001133/1 - 财政年份:2024
- 资助金额:
$ 127.63万 - 项目类别:
Research Grant
Space and Planetary Research at Lancaster University
兰卡斯特大学空间与行星研究
- 批准号:
ST/R000816/1 - 财政年份:2018
- 资助金额:
$ 127.63万 - 项目类别:
Research Grant
Space Weather Impacts on Ground-based Systems (SWIGS)
空间天气对地面系统的影响 (SWIGS)
- 批准号:
NE/P016715/1 - 财政年份:2017
- 资助金额:
$ 127.63万 - 项目类别:
Research Grant
STFC Consolidated Grant: Plasma environments in the solar system
STFC 综合拨款:太阳系中的等离子体环境
- 批准号:
ST/M001059/1 - 财政年份:2015
- 资助金额:
$ 127.63万 - 项目类别:
Research Grant
Expansion of state-of-the-art MR imaging infrastructure for pulmonary disease stratification: POLARIS
扩展用于肺部疾病分层的最先进的 MR 成像基础设施:POLARIS
- 批准号:
MR/M008894/1 - 财政年份:2015
- 资助金额:
$ 127.63万 - 项目类别:
Research Grant
A high-order model of the Earth's External and Induced Magnetic Field
地球外部磁场和感应磁场的高阶模型
- 批准号:
NE/J021792/1 - 财政年份:2013
- 资助金额:
$ 127.63万 - 项目类别:
Research Grant
A Place in the Sun: Taking Solar System Science to the Public
阳光下的一处:将太阳系科学带给公众
- 批准号:
ST/H000836/1 - 财政年份:2010
- 资助金额:
$ 127.63万 - 项目类别:
Fellowship
Investigating the Influence of Open Crustal Magnetic Field Regions on the Martian Ionosphere
研究开放地壳磁场区域对火星电离层的影响
- 批准号:
ST/G002320/1 - 财政年份:2010
- 资助金额:
$ 127.63万 - 项目类别:
Research Grant
www.sunearthplan.net
www.sunearthplan.net
- 批准号:
ST/G503152/1 - 财政年份:2009
- 资助金额:
$ 127.63万 - 项目类别:
Research Grant
Multipoint measurements of magnetospheric substorms: onset timing and tail reconnection rates
磁层亚暴的多点测量:爆发时间和尾部重联率
- 批准号:
PP/E001947/1 - 财政年份:2007
- 资助金额:
$ 127.63万 - 项目类别:
Research Grant
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