POSE: Phase I: Scoping the transition of Rosetta to a self-sustaining Open Source Ecosystem

POSE：第一阶段：确定 Rosetta 向自我维持的开源生态系统过渡的范围

• 批准号: 2229291
• 负责人: Neil King
• 金额: $ 30万
• 依托单位: University of Washington
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-15 至 2024-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2229291&HistoricalAwards=false
• 关键词: POSE; Phase; Scoping; transition; Rosetta

This project is funded by Pathways to Enable Open-Source Ecosystems (POSE) which seeks to harness the power of open-source development for the creation of new technology solutions to problems of national and societal importance. The Rosetta community has led the field of protein and RNA modeling and design for the last two decades with state-of-the-art biomolecular modeling and design software, high-impact scientific advances enabled by the software, and a workforce with best-in-class biomolecular engineering training. The biomolecular modeling landscape is rapidly changing with the emergence of powerful machine learning methods, and the recent entry of several computationally designed proteins into clinical trials have marked an inflection point in the history of the field. These disruptions have prompted the Rosetta community to reimagine their practices to enable continued leadership and innovation in the next era of biomolecular modeling. Specifically, Rosetta’s existing paid commercial license model limits Rosetta’s accessibility and impact, and de-incentivizes critical contributions from industry scientists.Second, Rosetta's remarkable success has led to dramatic expansion of both the software and community, yet the operational structure of the community has not been updated accordingly, limiting workforce growth, software development, and the diversity of perspectives thatultimately lead to higher-impact scientific advances. This project will create opportunities for coordinated and strategic software development by leveraging, growing, and supporting the Rosetta community to provide best-in-class software. The project will serve the national interest by driving the next generation of the leading biomolecular modeling and design software that enables scientific discovery and innovation across the health, food, and energy sectors.This research will scope and build an open-source ecosystem (OSE) for the Rosetta software and community. Specifically, the goals are to: (1) Create a Strategic Plan that aligns efforts and drives progress by identifying high-impact opportunities in the biomolecular modelingand design ecosystem that the software, science, and community embodied in a Rosetta OSE will realize; (2) Define an organizational structure capable of rapid and informed decision-making, empowering community members and leaders in a “do-ocracy” such thatscientific discovery, code development, and community engagement are all equally incentivized; and (3) Identify long-term funding and social engagement strategies that yield expanded and active user- and contributor-bases that sustain Rosetta’s impact and leadership. Learn more about Rosetta at http://www.rosettacommons.org.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该项目由 Pathways to Enable Open-Source Ecosystems (POSE) 资助，旨在利用开源开发的力量，为国家和社会重要问题创建新技术解决方案。过去二十年来，Rosetta 社区凭借最先进的生物分子建模和设计软件、软件带来的高影响力的科学进步以及受过一流生物分子工程培训的员工队伍，在蛋白质和 RNA 建模和设计领域处于领先地位。随着强大的机器学习方法的出现，生物分子建模领域正在迅速变化，最近几种计算设计的蛋白质进入临床试验标志着该领域历史上的一个转折点。这些颠覆促使 Rosetta 社区重新构想他们的实践，以便在下一个生物分子建模时代保持持续的领导力和创新。具体来说，Rosetta 现有的付费商业许可模式限制了 Rosetta 的可访问性和影响力，并抑制了行业科学家的关键贡献。其次，Rosetta 的显着成功导致软件和社区的急剧扩张，但社区的运营结构尚未相应更新，限制了劳动力增长、软件开发以及最终带来更高影响力的科学进步的观点多样性。该项目将通过利用、发展和支持 Rosetta 社区提供一流的软件，为协调和战略性软件开发创造机会。该项目将通过推动下一代领先的生物分子建模和设计软件来服务国家利益，从而实现健康、食品和能源领域的科学发现和创新。这项研究将为 Rosetta 软件和社区确定范围并构建一个开源生态系统 (OSE)。具体来说，目标是： (1) 创建战略计划，通过识别 Rosetta OSE 中体现的软件、科学和社区将实现的生物分子建模和设计生态系统中的高影响力机会来协调努力并推动进展； (2) 定义一个能够快速、知情决策的组织结构，在“执行统治”中赋予社区成员和领导者权力，从而平等地激励科学发现、代码开发和社区参与； (3) 确定长期资助和社会参与战略，以扩大和活跃的用户和贡献者基础，从而维持 Rosetta 的影响力和领导地位。要了解有关 Rosetta 的更多信息，请访问 http://www.rosettacommons.org。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。