Collaborative Research: Infrared Chiral Metasurface Enhanced Vibrational Circular Dichroism Biomolecule Sensing
合作研究:红外手性超表面增强振动圆二色性生物分子传感
基本信息
- 批准号:2230071
- 负责人:
- 金额:$ 23.87万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-10-01 至 2025-09-30
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
Developing nano-biosensing techniques for the detection and characterization of biomolecules with high sensitivity and selectivity is critically important for food safety and nutrition, biomedical pathogen detection, point-of-care healthcare, early disease diagnostics, and environment monitoring. However, the major challenge for the existing nano-biosensors is to distinguish and identify complex chiral biomolecules with ultrahigh sensitivity, which is highly demanded for rapid protein analysis, early disease detection and real-time monitoring. In this project, a new type of biomolecule sensing platform enhanced by infrared chiral metasurfaces will be developed and demonstrated to detect and identify different types of protein structures, with the advantages of ultrahigh detection sensitivity and high signal-to-noise ratio. This research will benefit many biomedical and photonic applications in early disease diagnosis, pharmaceutical drug discovery, quantum sensing and remote communication. This project also includes educational activities for training graduate students, recruiting underrepresented and female students, and mentoring high school students in outreach programs.Plasmonic nano-biosensors have been widely used for the detection and characterization of biomolecules, where the sensing principle is based on refractive-index induced spectral shift or surface enhanced vibrational absorption. However, it is difficult for these nano-biosensors to identify secondary structures of biomolecules, which usually have similar featureless infrared absorption spectra. The goal of this project is to study a new type of vibrational circular dichroism biosensing platform enhanced by chiral metasurfaces for the detection and identification of protein secondary structures with ultrahigh detection sensitivity and high signal-to-noise ratio. A new chiroptical sensing paradigm will be created relying on the on-resonance interactions between the superchiral near-fields and the vibrational fingerprints of chiral biomolecules. In this project, various types of mid-infrared chiral metasurfaces with high circular dichroism will be designed and analyzed for biomolecule sensing. Nanofabrication processes will be developed to fabricate chiral metasurfaces and integrate the microfluidic cells with protein solutions. The chiral biomolecule sensing platform will be characterized using infrared chiroptical measurements to demonstrate the ultrasensitive identification and detection of protein secondary structures.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
开发用于检测和表征具有高灵敏度和选择性的生物分子的纳米生物传感技术对于食品安全和营养、生物医学病原体检测、即时保健、早期疾病诊断和环境监测至关重要。然而,现有的纳米生物传感器的主要挑战是区分和识别复杂的手性生物分子,这是快速蛋白质分析,早期疾病检测和实时监测的高度需求。本项目将开发并演示一种新型的红外手性超表面增强的生物分子传感平台,用于检测和识别不同类型的蛋白质结构,具有高检测灵敏度和高信噪比的优点。这项研究将有利于许多生物医学和光子应用在早期疾病诊断,药物发现,量子传感和远程通信。该项目还包括培训研究生的教育活动,招募代表性不足的学生和女学生,并在外联方案中指导高中生。等离子体纳米生物传感器已广泛用于生物分子的检测和表征,其中传感原理基于折射率诱导的光谱位移或表面增强的振动吸收。然而,这些纳米生物传感器很难识别生物分子的二级结构,它们通常具有相似的无特征的红外吸收光谱。本项目的目标是研究一种新型的手性超表面增强的振动圆二色谱生物传感平台,用于蛋白质二级结构的检测和鉴定,具有较高的检测灵敏度和信噪比。基于超手性近场与手性生物分子的振动指纹之间的共振相互作用,将建立一种新的手性光学传感模式。本计画将设计并分析各种具有高圆二色性的中红外手性超颖表面,以应用于生物分子感测。纳米纤维工艺将被开发用于制造手性超颖表面,并将微流体细胞与蛋白质溶液集成。手性生物分子传感平台将使用红外手性光学测量来表征,以展示蛋白质二级结构的超灵敏识别和检测。该奖项反映了NSF的法定使命,并通过使用基金会的知识价值和更广泛的影响审查标准进行评估,被认为值得支持。
项目成果
期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Chiral metasurfaces of wavy rectangle resonators with tunable circular dichroism
- DOI:10.1016/j.ijleo.2023.171024
- 发表时间:2023-05
- 期刊:
- 影响因子:3.1
- 作者:Xiang-hua Zeng;D. Rosenmann;D. Czaplewski;Jie Gao;Xiaodong Yang
- 通讯作者:Xiang-hua Zeng;D. Rosenmann;D. Czaplewski;Jie Gao;Xiaodong Yang
Wavelength-tunable infrared chiral metasurfaces with phase-change materials
- DOI:10.1364/oe.489841
- 发表时间:2023-06-19
- 期刊:
- 影响因子:3.8
- 作者:Tang, Haotian;Stan, Liliana;Gao, Jie
- 通讯作者:Gao, Jie
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Xiaodong Yang其他文献
Body size determines multitrophic soil microbiota community assembly associated with soil and plant attributes in a tropical seasonal rainforest
体型大小决定了与热带季节性雨林土壤和植物属性相关的多营养土壤微生物群落组装
- DOI:
10.1111/mec.16585 - 发表时间:
2022-06 - 期刊:
- 影响因子:4.9
- 作者:
Wenting Wang;Zhenhua Sun;S;hya Mishra;Shangwen Xia;Luxiang Lin;Xiaodong Yang - 通讯作者:
Xiaodong Yang
Designing structured supply contracts under demand and price uncertainty in an open supply chain
在开放供应链中的需求和价格不确定性下设计结构化供应合同
- DOI:
10.1007/s10479-016-2136-1 - 发表时间:
2017-10 - 期刊:
- 影响因子:4.8
- 作者:
Zhanping Cheng;Xiaodong Yang;Andy A. Tsay - 通讯作者:
Andy A. Tsay
Optimized Phase-Sensitive Inversion Recovery for MRI Contrast Manipulation
用于 MRI 对比度操作的优化相敏反转恢复
- DOI:
10.1007/s00723-014-0629-0 - 发表时间:
2015 - 期刊:
- 影响因子:1
- 作者:
Yan Chang;Daxiu Wei;S. Glaser;Xiaodong Yang - 通讯作者:
Xiaodong Yang
Seismogenic Structure and Tectonic Mechanism of the 2021 Mw 5.0 Yancheng Earthquake in the South Yellow Sea Basin, East Asia
2021年东亚南黄海盆地Mw 5.0盐城地震的发震构造及构造机制
- DOI:
10.1785/0220220163 - 发表时间:
2022 - 期刊:
- 影响因子:3.3
- 作者:
Panpan Hu;Xiaodong Yang;Fengli Yang;Jinchang Zhang;Zhiyuan Zhou;Ruowen Dong - 通讯作者:
Ruowen Dong
Identification of healthy and pathological heartbeat dynamics based on ECG-waveform using multifractal spectrum
使用多重分形谱根据心电图波形识别健康和病理性心跳动态
- DOI:
10.1016/j.physa.2020.125021 - 发表时间:
2020-12 - 期刊:
- 影响因子:0
- 作者:
Xiaodong Yang;Zhixiao Wang;Aijun He;Jun Wang - 通讯作者:
Jun Wang
Xiaodong Yang的其他文献
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{{ truncateString('Xiaodong Yang', 18)}}的其他基金
Collaborative Research: 2D ferroelectric nonlinear metasurface holograms
合作研究:二维铁电非线性超表面全息图
- 批准号:
2226948 - 财政年份:2022
- 资助金额:
$ 23.87万 - 项目类别:
Standard Grant
CAREER: Light Manipulation in Metal-Dielectric Multilayer Metamaterials with Large Anisotropy
职业:具有大各向异性的金属介电多层超材料中的光操纵
- 批准号:
1552871 - 财政年份:2016
- 资助金额:
$ 23.87万 - 项目类别:
Continuing Grant
Infrared Perfect Absorbers and Thermal Emitters with Tunable and Ultrabroad Bandwidth Based on Metamaterial Cavities
基于超材料腔的具有可调谐超宽带宽的红外完美吸收器和热发射器
- 批准号:
1402743 - 财政年份:2014
- 资助金额:
$ 23.87万 - 项目类别:
Standard Grant
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