Collaborative Research: Infrared Chiral Metasurface Enhanced Vibrational Circular Dichroism Biomolecule Sensing

合作研究:红外手性超表面增强振动圆二色性生物分子传感

基本信息

项目摘要

Developing nano-biosensing techniques for the detection and characterization of biomolecules with high sensitivity and selectivity is critically important for food safety and nutrition, biomedical pathogen detection, point-of-care healthcare, early disease diagnostics, and environment monitoring. However, the major challenge for the existing nano-biosensors is to distinguish and identify complex chiral biomolecules with ultrahigh sensitivity, which is highly demanded for rapid protein analysis, early disease detection and real-time monitoring. In this project, a new type of biomolecule sensing platform enhanced by infrared chiral metasurfaces will be developed and demonstrated to detect and identify different types of protein structures, with the advantages of ultrahigh detection sensitivity and high signal-to-noise ratio. This research will benefit many biomedical and photonic applications in early disease diagnosis, pharmaceutical drug discovery, quantum sensing and remote communication. This project also includes educational activities for training graduate students, recruiting underrepresented and female students, and mentoring high school students in outreach programs.Plasmonic nano-biosensors have been widely used for the detection and characterization of biomolecules, where the sensing principle is based on refractive-index induced spectral shift or surface enhanced vibrational absorption. However, it is difficult for these nano-biosensors to identify secondary structures of biomolecules, which usually have similar featureless infrared absorption spectra. The goal of this project is to study a new type of vibrational circular dichroism biosensing platform enhanced by chiral metasurfaces for the detection and identification of protein secondary structures with ultrahigh detection sensitivity and high signal-to-noise ratio. A new chiroptical sensing paradigm will be created relying on the on-resonance interactions between the superchiral near-fields and the vibrational fingerprints of chiral biomolecules. In this project, various types of mid-infrared chiral metasurfaces with high circular dichroism will be designed and analyzed for biomolecule sensing. Nanofabrication processes will be developed to fabricate chiral metasurfaces and integrate the microfluidic cells with protein solutions. The chiral biomolecule sensing platform will be characterized using infrared chiroptical measurements to demonstrate the ultrasensitive identification and detection of protein secondary structures.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
开发具有高灵敏度和选择性的纳米生物传感技术来检测和表征生物分子,对于食品安全和营养、生物医学病原体检测、护理点医疗保健、早期疾病诊断和环境监测至关重要。然而,现有纳米生物传感器面临的主要挑战是如何以超高灵敏度区分和识别复杂的手性生物分子,这对快速蛋白质分析、早期疾病检测和实时监测提出了很高的要求。本项目将开发并演示一种基于红外手性超表面的新型生物分子传感平台,该平台具有超高的检测灵敏度和高信噪比,可用于检测和识别不同类型的蛋白质结构。这一研究将有助于在疾病早期诊断、药物发现、量子传感和远程通信等领域的生物医学和光子应用。该项目还包括培训研究生的教育活动,招募代表性不足的学生和女学生,并在拓展项目中指导高中生。等离子体纳米生物传感器被广泛应用于生物分子的检测和表征,其传感原理是基于折射率引起的光谱位移或表面增强振动吸收。然而,这些纳米生物传感器很难识别生物分子的二级结构,它们通常具有相似的无特征的红外吸收光谱。本项目旨在研究一种基于手性超表面增强的新型振动圆二色生物传感平台,用于具有超高检测灵敏度和高信噪比的蛋白质二级结构的检测和鉴定。基于超手性近场与手性生物分子的振动指纹之间的非共振相互作用,将创建一种新的手性传感范式。本课题将设计并分析多种具有高圆二色性的中红外手性超表面,用于生物分子传感。纳米工艺将被开发用于制造手性超表面,并将微流体细胞与蛋白质溶液结合起来。手性生物分子传感平台将采用红外热测量进行表征,以证明对蛋白质二级结构的超灵敏识别和检测。该奖项反映了美国国家科学基金会的法定使命,并通过使用基金会的知识价值和更广泛的影响审查标准进行评估,被认为值得支持。

项目成果

期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Chiral metasurfaces of wavy rectangle resonators with tunable circular dichroism
  • DOI:
    10.1016/j.ijleo.2023.171024
  • 发表时间:
    2023-05
  • 期刊:
  • 影响因子:
    3.1
  • 作者:
    Xiang-hua Zeng;D. Rosenmann;D. Czaplewski;Jie Gao;Xiaodong Yang
  • 通讯作者:
    Xiang-hua Zeng;D. Rosenmann;D. Czaplewski;Jie Gao;Xiaodong Yang
Wavelength-tunable infrared chiral metasurfaces with phase-change materials
  • DOI:
    10.1364/oe.489841
  • 发表时间:
    2023-06-19
  • 期刊:
  • 影响因子:
    3.8
  • 作者:
    Tang, Haotian;Stan, Liliana;Gao, Jie
  • 通讯作者:
    Gao, Jie
{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Xiaodong Yang其他文献

Motivators of Pro-Environmental Behavior
环保行为的动机
  • DOI:
  • 发表时间:
    2016
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Youqing Liao;S. Ho;Xiaodong Yang
  • 通讯作者:
    Xiaodong Yang
Toward Optimal Risk-Averse Configuration for HESS With CGANs-Based PV Scenario Generation
通过基于 CGAN 的光伏场景生成实现 HESS 的最佳风险规避配置
Quantum simulation of pairing models on an NMR quantum computer
核磁共振量子计算机上配对模型的量子模拟
  • DOI:
    10.1016/j.physleta.2005.12.012
  • 发表时间:
    2004-10
  • 期刊:
  • 影响因子:
    2.6
  • 作者:
    An Min Wang;Xiaodong Yang
  • 通讯作者:
    Xiaodong Yang
Acid-base bifunctional catalyst: Carboxyl ionic liquid immobilized on MIL-101-NH2 for rapid synthesis of propylene carbonate from CO2 and propylene oxide under facile solvent-free conditions
酸碱双功能催化剂:固定在MIL-101-NH2上的羧基离子液体,用于在轻松的无溶剂条件下由CO2和环氧丙烷快速合成碳酸丙烯酯
  • DOI:
    10.1016/j.micromeso.2018.03.011
  • 发表时间:
    2018-09
  • 期刊:
  • 影响因子:
    5.2
  • 作者:
    Tongtong Wang;Xuedan Song;Qun-Xing Luo;Xiaodong Yang;Siying Chong;Jie Zhang;Min Ji
  • 通讯作者:
    Min Ji
Message Presentation Is of Importance as Well: The Asymmetric Effects of Numeric and Verbal Presentation of Fear Appeal Messages in Promoting Waste Sorting
信息表达也很重要:恐惧诉求信息的数字和口头呈现对促进垃圾分类的不对称影响
  • DOI:
    10.1080/17524032.2022.2151487
  • 发表时间:
    2022
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Xiaodong Yang;Lianshan Zhang
  • 通讯作者:
    Lianshan Zhang

Xiaodong Yang的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Xiaodong Yang', 18)}}的其他基金

Collaborative Research: 2D ferroelectric nonlinear metasurface holograms
合作研究:二维铁电非线性超表面全息图
  • 批准号:
    2226948
  • 财政年份:
    2022
  • 资助金额:
    $ 23.87万
  • 项目类别:
    Standard Grant
CAREER: Light Manipulation in Metal-Dielectric Multilayer Metamaterials with Large Anisotropy
职业:具有大各向异性的金属介电多层超材料中的光操纵
  • 批准号:
    1552871
  • 财政年份:
    2016
  • 资助金额:
    $ 23.87万
  • 项目类别:
    Continuing Grant
Infrared Perfect Absorbers and Thermal Emitters with Tunable and Ultrabroad Bandwidth Based on Metamaterial Cavities
基于超材料腔的具有可调谐超宽带宽的红外完美吸收器和热发射器
  • 批准号:
    1402743
  • 财政年份:
    2014
  • 资助金额:
    $ 23.87万
  • 项目类别:
    Standard Grant

相似国自然基金

Research on Quantum Field Theory without a Lagrangian Description
  • 批准号:
    24ZR1403900
  • 批准年份:
    2024
  • 资助金额:
    0.0 万元
  • 项目类别:
    省市级项目
Cell Research
  • 批准号:
    31224802
  • 批准年份:
    2012
  • 资助金额:
    24.0 万元
  • 项目类别:
    专项基金项目
Cell Research
  • 批准号:
    31024804
  • 批准年份:
    2010
  • 资助金额:
    24.0 万元
  • 项目类别:
    专项基金项目
Cell Research (细胞研究)
  • 批准号:
    30824808
  • 批准年份:
    2008
  • 资助金额:
    24.0 万元
  • 项目类别:
    专项基金项目
Research on the Rapid Growth Mechanism of KDP Crystal
  • 批准号:
    10774081
  • 批准年份:
    2007
  • 资助金额:
    45.0 万元
  • 项目类别:
    面上项目

相似海外基金

Collaborative Research: DMREF: Organic Materials Architectured for Researching Vibronic Excitations with Light in the Infrared (MARVEL-IR)
合作研究:DMREF:用于研究红外光振动激发的有机材料 (MARVEL-IR)
  • 批准号:
    2409552
  • 财政年份:
    2024
  • 资助金额:
    $ 23.87万
  • 项目类别:
    Continuing Grant
Collaborative Research: DMREF: Organic Materials Architectured for Researching Vibronic Excitations with Light in the Infrared (MARVEL-IR)
合作研究:DMREF:用于研究红外光振动激发的有机材料 (MARVEL-IR)
  • 批准号:
    2323667
  • 财政年份:
    2023
  • 资助金额:
    $ 23.87万
  • 项目类别:
    Continuing Grant
Collaborative Research: DMREF: Organic Materials Architectured for Researching Vibronic Excitations with Light in the Infrared (MARVEL-IR)
合作研究:DMREF:用于研究红外光振动激发的有机材料 (MARVEL-IR)
  • 批准号:
    2323666
  • 财政年份:
    2023
  • 资助金额:
    $ 23.87万
  • 项目类别:
    Continuing Grant
Collaborative Research: DMREF: Organic Materials Architectured for Researching Vibronic Excitations with Light in the Infrared (MARVEL-IR)
合作研究:DMREF:用于研究红外光振动激发的有机材料 (MARVEL-IR)
  • 批准号:
    2323668
  • 财政年份:
    2023
  • 资助金额:
    $ 23.87万
  • 项目类别:
    Continuing Grant
Collaborative Research: DMREF: Organic Materials Architectured for Researching Vibronic Excitations with Light in the Infrared (MARVEL-IR)
合作研究:DMREF:用于研究红外光振动激发的有机材料 (MARVEL-IR)
  • 批准号:
    2323665
  • 财政年份:
    2023
  • 资助金额:
    $ 23.87万
  • 项目类别:
    Continuing Grant
Collaborative Research: DMREF: Organic Materials Architectured for Researching Vibronic Excitations with Light in the Infrared (MARVEL-IR)
合作研究:DMREF:用于研究红外光振动激发的有机材料 (MARVEL-IR)
  • 批准号:
    2323669
  • 财政年份:
    2023
  • 资助金额:
    $ 23.87万
  • 项目类别:
    Continuing Grant
Collaborative Research: WoU-MMA: Opening the Infrared Window into Multi-Messenger Astrophysics
合作研究:WoU-MMA:打开多信使天体物理学的红外窗口
  • 批准号:
    2206730
  • 财政年份:
    2022
  • 资助金额:
    $ 23.87万
  • 项目类别:
    Standard Grant
Collaborative Research: Wavelength-Scalable, Room-Temperature Mid-Infrared Photodetectors Based on Multiphoton-Assisted Tunneling
合作研究:基于多光子辅助隧道的波长可扩展、室温中红外光电探测器
  • 批准号:
    2210861
  • 财政年份:
    2022
  • 资助金额:
    $ 23.87万
  • 项目类别:
    Standard Grant
Collaborative Research: Wavelength-Scalable, Room-Temperature Mid-Infrared Photodetectors Based on Multiphoton-Assisted Tunneling
合作研究:基于多光子辅助隧道的波长可扩展、室温中红外光电探测器
  • 批准号:
    2210977
  • 财政年份:
    2022
  • 资助金额:
    $ 23.87万
  • 项目类别:
    Standard Grant
Collaborative Research: Infrared Chiral Metasurface Enhanced Vibrational Circular Dichroism Biomolecule Sensing
合作研究:红外手性超表面增强振动圆二色性生物分子传感
  • 批准号:
    2230069
  • 财政年份:
    2022
  • 资助金额:
    $ 23.87万
  • 项目类别:
    Standard Grant
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了