Collaborative Research: Infrared Chiral Metasurface Enhanced Vibrational Circular Dichroism Biomolecule Sensing

合作研究：红外手性超表面增强振动圆二色性生物分子传感

• 批准号: 2230071
• 负责人: Xiaodong Yang
• 金额: $ 23.87万
• 依托单位: Missouri University of Science and Technology
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-10-01 至 2025-09-30
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2230071&HistoricalAwards=false
• 关键词: Collaborative; Research; Infrared; Chiral; Metasurface

Developing nano-biosensing techniques for the detection and characterization of biomolecules with high sensitivity and selectivity is critically important for food safety and nutrition, biomedical pathogen detection, point-of-care healthcare, early disease diagnostics, and environment monitoring. However, the major challenge for the existing nano-biosensors is to distinguish and identify complex chiral biomolecules with ultrahigh sensitivity, which is highly demanded for rapid protein analysis, early disease detection and real-time monitoring. In this project, a new type of biomolecule sensing platform enhanced by infrared chiral metasurfaces will be developed and demonstrated to detect and identify different types of protein structures, with the advantages of ultrahigh detection sensitivity and high signal-to-noise ratio. This research will benefit many biomedical and photonic applications in early disease diagnosis, pharmaceutical drug discovery, quantum sensing and remote communication. This project also includes educational activities for training graduate students, recruiting underrepresented and female students, and mentoring high school students in outreach programs.Plasmonic nano-biosensors have been widely used for the detection and characterization of biomolecules, where the sensing principle is based on refractive-index induced spectral shift or surface enhanced vibrational absorption. However, it is difficult for these nano-biosensors to identify secondary structures of biomolecules, which usually have similar featureless infrared absorption spectra. The goal of this project is to study a new type of vibrational circular dichroism biosensing platform enhanced by chiral metasurfaces for the detection and identification of protein secondary structures with ultrahigh detection sensitivity and high signal-to-noise ratio. A new chiroptical sensing paradigm will be created relying on the on-resonance interactions between the superchiral near-fields and the vibrational fingerprints of chiral biomolecules. In this project, various types of mid-infrared chiral metasurfaces with high circular dichroism will be designed and analyzed for biomolecule sensing. Nanofabrication processes will be developed to fabricate chiral metasurfaces and integrate the microfluidic cells with protein solutions. The chiral biomolecule sensing platform will be characterized using infrared chiroptical measurements to demonstrate the ultrasensitive identification and detection of protein secondary structures.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

开发具有高灵敏度和选择性的纳米生物传感技术来检测和表征生物分子，对于食品安全和营养、生物医学病原体检测、护理点医疗保健、早期疾病诊断和环境监测至关重要。然而，现有纳米生物传感器面临的主要挑战是如何以超高灵敏度区分和识别复杂的手性生物分子，这对快速蛋白质分析、早期疾病检测和实时监测提出了很高的要求。本项目将开发并演示一种基于红外手性超表面的新型生物分子传感平台，该平台具有超高的检测灵敏度和高信噪比，可用于检测和识别不同类型的蛋白质结构。这一研究将有助于在疾病早期诊断、药物发现、量子传感和远程通信等领域的生物医学和光子应用。该项目还包括培训研究生的教育活动，招募代表性不足的学生和女学生，并在拓展项目中指导高中生。等离子体纳米生物传感器被广泛应用于生物分子的检测和表征，其传感原理是基于折射率引起的光谱位移或表面增强振动吸收。然而，这些纳米生物传感器很难识别生物分子的二级结构，它们通常具有相似的无特征的红外吸收光谱。本项目旨在研究一种基于手性超表面增强的新型振动圆二色生物传感平台，用于具有超高检测灵敏度和高信噪比的蛋白质二级结构的检测和鉴定。基于超手性近场与手性生物分子的振动指纹之间的非共振相互作用，将创建一种新的手性传感范式。本课题将设计并分析多种具有高圆二色性的中红外手性超表面，用于生物分子传感。纳米工艺将被开发用于制造手性超表面，并将微流体细胞与蛋白质溶液结合起来。手性生物分子传感平台将采用红外热测量进行表征，以证明对蛋白质二级结构的超灵敏识别和检测。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Chiral metasurfaces of wavy rectangle resonators with tunable circular dichroism

• DOI: 10.1016/j.ijleo.2023.171024
• 发表时间: 2023-05
• 期刊: Optik
• 影响因子: 3.1
• 作者: Xiang-hua Zeng;D. Rosenmann;D. Czaplewski;Jie Gao;Xiaodong Yang

Wavelength-tunable infrared chiral metasurfaces with phase-change materials

• DOI: 10.1364/oe.489841
• 发表时间: 2023-06-19
• 期刊: OPTICS EXPRESS
• 影响因子: 3.8
• 作者: Tang, Haotian;Stan, Liliana;Gao, Jie
• 通讯作者: Gao, Jie