I-Corps: Tunable Porosity Aerogel for Wound-Care Dressing
I-Corps:用于伤口护理敷料的可调孔隙率气凝胶
基本信息
- 批准号:2230348
- 负责人:
- 金额:$ 5万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-07-01 至 2023-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The broader impact/commercial potential of this I-Corps project is the development of a proposed aerogel wound dressing that may help heal patients with chronic wounds. The total treatment cost for patients with chronic wounds could be reduced as they may heal faster but also possibly require fewer dressing changes eliminating the use of multiple dressings. Since the proposed technology is biodegradable, it is also possible that the technology makes the wound healing process more sustainable.This I-Corps project is based on the development of a class of novel bio-based aerogels for wound dressings, which could help address the current issues in chronic wound-healing today. Aerogels possess a unique combination of high porosity, high surface area, an abundance of mesopores, and capillary action that result in properties like high absorbance, gas exchange, and moisture balance at the wound interface which may create an incubator-like environment that possibly reduces the formation of biofilm and protects the wound from pathogens. Being bio-based the proposed technology may possess increased biocompatibility and biodegradability, as well as possibly providing the wound site with necessary proteins that may improve the healing process. Bio-based aerogel materials have absorbance capacities up to 50 times their weight compared with 7-8 times for popular commercial chronic wound dressings. The physicochemical properties of these materials may be useful for the wound healing environment.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
这个I-Corps项目的更广泛的影响/商业潜力是开发一种拟议的气凝胶伤口敷料,可能有助于治愈慢性伤口患者。慢性伤口患者的总治疗成本可以降低,因为他们可以更快地愈合,但也可能需要更少的敷料更换,消除了使用多种敷料。由于该技术是可生物降解的,因此该技术也可能使伤口愈合过程更具可持续性。I-Corps项目基于开发一类用于伤口敷料的新型生物基气凝胶,这可能有助于解决当今慢性伤口愈合的问题。气凝胶具有高孔隙率、高表面积、丰富的中孔和毛细作用的独特组合,从而在伤口界面产生高吸收性、气体交换和水分平衡等特性,这可能会创造一个类似孵化器的环境,从而可能减少生物膜的形成并保护伤口免受病原体的侵害。作为生物基的,所提出的技术可以具有增加的生物相容性和生物降解性,以及可能为伤口部位提供可以改善愈合过程的必要蛋白质。生物基气凝胶材料的吸收能力高达其重量的50倍,而流行的商业慢性伤口敷料的吸收能力为7-8倍。这些材料的物理化学性质可能对伤口愈合环境有用。该奖项反映了NSF的法定使命,并通过使用基金会的知识价值和更广泛的影响审查标准进行评估,被认为值得支持。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Sadhan Jana其他文献
The influence of thin film adhesives in pullout tests between nickel–titanium shape memory alloy and carbon fiber reinforced polymer matrix composites
- DOI:
10.1016/j.compositesb.2019.107321 - 发表时间:
2019-11-01 - 期刊:
- 影响因子:
- 作者:
Derek Quade;Sadhan Jana;Linda McCorkle - 通讯作者:
Linda McCorkle
2‐Fluoro‐6‐(pyrimidin‐5‐yl)aniline
1
2-氟-6-(嘧啶-5-基)苯胺1
- DOI:
10.1002/047084289x.rn02354 - 发表时间:
2021 - 期刊:
- 影响因子:0
- 作者:
Sadhan Jana;Trisha Bhattacharya;Debabrata Maiti - 通讯作者:
Debabrata Maiti
Simultaneous Inhibition of SIRT3 and Cholesterol Homeostasis Targets AML Stem Cells By Perturbing Fatty Acid β-Oxidation and Inducing Lipotoxicity
- DOI:
10.1182/blood-2022-157794 - 发表时间:
2022-11-15 - 期刊:
- 影响因子:
- 作者:
Cristiana O'Brien;Tianyi Ling;Jacob Berman;Rachel Culp-Hill;Julie A. Reisz;Vincent Rondeau;Soheil Jahangiri;Jonathan St-Germain;Vinitha Macwan;Audrey Astori;Andy G.X. Zeng;Jun Young Hong;Meng Li;Min Yang;Sadhan Jana;John E. Dick;Hening Lin;Ari Melnick;Anastasia N Tikhonova;Andrea Arruda - 通讯作者:
Andrea Arruda
Sadhan Jana的其他文献
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{{ truncateString('Sadhan Jana', 18)}}的其他基金
Graduate Traineeship on Advances in Materials Science using Machine Learning
使用机器学习促进材料科学进展的研究生实习
- 批准号:
2152210 - 财政年份:2022
- 资助金额:
$ 5万 - 项目类别:
Continuing Grant
Continuous Manufacturing of Aerogel-Foam Sheets and Films
气凝胶泡沫片材和薄膜的连续制造
- 批准号:
1826030 - 财政年份:2018
- 资助金额:
$ 5万 - 项目类别:
Standard Grant
Netshape Gradient Aerogel Articles Reinforced By Hybrid Molecules and Polymers
由杂化分子和聚合物增强的 Netshape 梯度气凝胶制品
- 批准号:
1200484 - 财政年份:2012
- 资助金额:
$ 5万 - 项目类别:
Standard Grant
GOALI: Collaborative Research: Processing of Self-assembled, Bottom-Up Polymeric Nanocomposite Materials
目标:合作研究:自组装、自下而上的聚合物纳米复合材料的加工
- 批准号:
0727231 - 财政年份:2007
- 资助金额:
$ 5万 - 项目类别:
Continuing Grant
CAREER: Research and Education on Multi-Scale Structure Development in Chaotic Mixing of Polymers
职业:聚合物混沌混合中多尺度结构发展的研究和教育
- 批准号:
0134106 - 财政年份:2002
- 资助金额:
$ 5万 - 项目类别:
Standard Grant
Surface Conductivity of Molded Sheets and Films of Conductive Polymer Compounds
导电聚合物化合物模压片材和薄膜的表面电导率
- 批准号:
9902054 - 财政年份:1999
- 资助金额:
$ 5万 - 项目类别:
Standard Grant
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