CAREER: Aerosol transport in well-defined periodic porous metamaterials

职业：明确的周期性多孔超材料中的气溶胶传输

• 批准号: 2237430
• 负责人: Catherine Fromen
• 金额: $ 61.5万
• 依托单位: University of Delaware
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-02-01 至 2028-01-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2237430&HistoricalAwards=false
• 关键词: CAREER; Aerosol; transport; well; defined

Tiny solid or liquid droplets suspended in air called ‘aerosols’ are all around us and have major impacts to our health and environment. Aerosols of certain properties can deposit in the human airway, with potential detrimental outcomes, such as the spread of airborne diseases such as COVID-19, or positive outcomes, such as inhalers that deliver medicines or vaccines. In these examples, the lung effectively acts as a porous filter, collecting some fraction of inhaled aerosols as they travel through the complex airway structure. The movement of aerosols through porous structures such as the lung is very difficult to predict and depends on the background airflow, the local porous structure, and the individual aerosol properties. This Faculty Early Career Development Program (CAREER) award seeks to understand how aerosols travel through porous structures with similar porosities to the human lung using model porous materials with a regular and well-defined structure. Leveraging this understanding of aerosol movement in regular porous structures could ultimately lead to development of better inhalable medicines or protection against environmental exposures. This award will also involve a set of educational activities related to the scientific work that seek to diversify the scientific pipeline, support public engagement with scientific communication, and mentor socially aware research scientists.The overall objective of this award is to build fundamental understanding of aerosol transport through well-defined porous lattices, using both experimental and computational multiphase approaches. Aerosol transport within lattices will be studied to establish predictive fundamental relationships within uniform lattices, as well as deposition within asymmetric and patterned lattices, under cyclic flow profiles, and within tapered pipes. Knowledge of deposition within varied lattice designs will then be implemented to approximate spatial deposition in an innovative dynamic lung model, using lattice structures to provide meaningful spatial approximations of inhaled aerosols that map to anatomic regions of the human lung. This award also aims to integrate educational activities to empower scientific communicators and strengthen multilayered student communities for student success and STEM engagement. This award represents a synergistic research methodology to enhance the mechanistic understanding of aerosol dynamics within periodic, well-defined porous structures while growing a sustainable and integrated approach to educational STEM impacts.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

悬挂在称为“气溶胶”的空气中的微小固体或液体液滴都在我们周围，对我们的健康和环境产生了重大影响。某些特性的气溶胶可以沉积在人类气道中，并具有潜在的有害结果，例如空中疾病的传播，例如Covid-19，或阳性结果，例如提供药物或疫苗的遗传。在这些示例中，肺有效地充当多孔过滤器，在穿过复杂的气道结构时收集了一小部分继承的气溶胶。气溶胶通过肺等多孔结构的运动很难预测，并取决于背景气流，局部多孔结构和各个气溶胶特性。这项教师早期职业发展计划（职业）奖旨在了解气溶胶如何使用具有常规且定义明确的结构的模型多孔材料穿越与人肺相似的多孔结构。利用对常规多孔结构中的气溶胶运动的理解最终可能导致开发更好的吸入药物或保护环境暴露。该奖项还将涉及与科学工作有关的一系列教育活动，该活动试图多样化科学管道，支持与科学交流的公众参与以及具有精神社会意识的研究科学家。该奖项的总体目标是使用实验和计算多个酶方法来建立对气溶胶运输的基本了解。晶格内的气溶胶运输将研究以建立均匀晶格内的预测基本关系，以及在不对称和图案的晶格中，在环状流量剖面和锥形管道中的沉积。然后，将使用晶格结构在创新的动态肺模型中实施各种晶格设计中沉积的知识，以在创新的动态肺模型中近似空间沉积。该奖项还旨在整合教育活动，以增强科学沟通者的能力，并加强多层学生社区，以获得学生的成功和STEM参与。该奖项代表了一种协同的研究方法，旨在增强对周期性，定义明确的多孔结构中的气溶胶动态的机械理解，同时在发展一种可持续和综合的教育词干影响方法。该奖项反映了NSF的法定任务，并被认为是通过使用该基金会的智力和更广泛影响的评估来审查CRITERIA的评估来通过评估来获得的支持。