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Monitoring diffusion processes in nanoporous block copolymer membranes with high spatial and temporal resolution

以高空间和时间分辨率监测纳米多孔嵌段共聚物膜中的扩散过程

基本信息

批准号：
253503811
负责人：
Professor Dr. Jürgen Köhler
金额：
--
依托单位：
Institut für Organische Chemie und Makromolekulare Chemie
依托单位国家：
德国
项目类别：
Research Grants
财政年份：
2014
资助国家：
德国
起止时间：
2013-12-31 至 2016-12-31
项目状态：
已结题

来源：
https://gepris.dfg.de/gepris/projekt/253503811?language=en
关键词：
Monitoring diffusion processes nanoporous block

项目摘要

The proposed project aims at the investigation of transport processes in switchable diblock copolymer membranes with nanometer-sized pores with high temporal and spatial resolution. The membranes will be prepared by non-solvent induced phase separation (NIPS) from suitable amphiphilic block copolymers which will be synthesized using living/controlled polymerization techniques. The hydrophobic (polystyrene) block will form the matrix of the structures and the hydrophilic segments covers the pore walls. As hydrophilic block we plan to use a material, which solubility in aqueous media can be reversibly altered through external stimuli. Possible envisioned triggers are changes in the pH (e.g., poly(2-dimethylaminoethyl methacrylate), PDMAEMA), temperature (copolymers from PDMAEMA and poly(methyl methacrylate), PMMA), or the irradiation with light of a specific wavelength (copolymers of poly(N-isopropylmethacrylamide), PNiPAAm, and poly(spiropyrane methacrylate), PSPMA). The transport processes will be monitored using 3D single particle optical tracking (3D-SPOT) with fluorescently labeled particles of suitable size (d < 50 nm). The recorded diffusion paths will be compared with reconstructed 3D models of membranes by transmission electron microscopy tomography (TEMT) using semi-thin microtome slices (200-300 nm). Prior to that, the membranes will be embedded within suitable resins.

该项目旨在研究具有高时间和空间分辨率的纳米孔的可切换二嵌段共聚物膜中的传输过程。膜将通过非溶剂诱导相分离（NIPS）从合适的两亲性嵌段共聚物制备，所述两亲性嵌段共聚物将使用活性/可控聚合技术合成。疏水性（聚苯乙烯）嵌段将形成结构的基质，并且亲水性链段覆盖孔壁。作为亲水性嵌段，我们计划使用一种材料，其在水介质中的溶解度可以通过外部刺激可逆地改变。可能设想的触发因素是pH的变化（例如，聚（甲基丙烯酸2-二甲氨基乙酯），PDMAEMA），温度（PDMAEMA和聚（甲基丙烯酸甲酯）的共聚物，PMMA），或用特定波长的光照射（聚（N-异丙基甲基丙烯酰胺）的共聚物，PNiPAAm，和聚（螺吡喃甲基丙烯酸酯），PSPMA）。将使用3D单颗粒光学跟踪（3D-SPOT）和适当尺寸（d < 50 nm）的荧光标记颗粒监测转运过程。将记录的扩散路径与使用半薄切片机切片（200-300 nm）通过透射电子显微镜断层扫描（TEMT）重建的膜3D模型进行比较。在此之前，膜将嵌入合适的树脂中。