CAREER: Intelligent Multi-Contrast Imaging Platform for Needle-Based Interventions

职业：用于针干预的智能多对比成像平台

• 批准号: 2238648
• 负责人: Qinggong Tang
• 金额: $ 50.22万
• 依托单位: University of Oklahoma Norman Campus
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-01 至 2028-03-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2238648&HistoricalAwards=false
• 关键词: CAREER; Intelligent; Multi; Contrast; Imaging

Needle-based interventions (NBIs) are procedures that require a minimally invasive approach to mitigate tissue damage. This Faculty Early Career Development Program (CAREER) project aims to develop an intelligent and miniaturized imaging platform that can recognize tissue structures in real-time. The resulting platform will be small enough to fit inside of a medical needle and able to quickly collect detailed images that will train an automated machine learning tool for improved needle guidance. The outcomes of the research will inform the design of future technologies to improve NBI outcomes and multi-contrast imaging. A comprehensive integrated education plan will be initiated to serve Native American students. This effort will allow Native American students to have access to world-class research facilities and increase STEM participation and retention. Other educational activities including curriculum development and specific microscope demonstrations for local K-12 students will be organized to increase the students’ interest in bioimaging.This CAREER project will establish a new research paradigm for imaging in needle-based interventions through integrating a unique forward-imaging multi-contrast optical coherent tomography (MC-OCT) needle technology with advanced computer-aided guidance tools. Endoscopic systems have been widely reported, however, they are not suitable for NBI guidance as they are limited by probe size and optical design. The proposed MC-OCT needle will incorporate forward-imaging capability and eliminates the need to scan optics inside the body. This miniaturized OCT system can fit inside the hollow bore of relevant needle geometries for different NBIs without additional invasiveness and needle modification. Integrated quantitative polarization-sensitive capability into this MC-OCT needle device will promote further understanding the tissue composition and enhance the contrast between different tissue types. In collaboration with the Riverside Indian School, the project will develop the Biophotonics for Native Americans in Oklahoma program to engage and mentor local Native American high school students and teachers in biomedical engineering and optics.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

基于针的介入（NBI）是需要微创方法来减轻组织损伤的手术。这个教师早期职业发展计划（CAREER）项目旨在开发一个智能和小型化的成像平台，可以实时识别组织结构。由此产生的平台将足够小，可以安装在医疗针头内部，并能够快速收集详细的图像，这些图像将训练自动化机器学习工具，以改进针头引导。研究结果将为未来技术的设计提供信息，以改善NBI结果和多对比成像。将启动一项全面的综合教育计划，为美洲土著学生服务。这一努力将使美国原住民学生能够获得世界一流的研究设施，并提高STEM的参与和保留率。其他教育活动包括课程发展和为本地K-12学生举办的特定显微镜演示，以提高学生对生物成像的兴趣。这个CAREER项目将通过整合独特的前向成像多对比度光学相干断层扫描（MC-OCT）针技术和先进的计算机辅助指导工具，建立一个新的研究范式，用于针基干预的成像。内窥镜系统已被广泛报道，但是，它们不适合NBI引导，因为它们受到探头尺寸和光学设计的限制。申报的MC-OCT针将具有前向成像能力，无需扫描体内的光学器件。这种小型化OCT系统可以适合不同NBIs的相关针几何形状的中空孔内，而无需额外的侵入性和针修改。将定量偏振敏感能力集成到该MC-OCT针装置中将促进进一步了解组织成分并增强不同组织类型之间的对比度。该项目将与滨江印第安学校合作，为俄克拉荷马州的美洲原住民开发生物光子学项目，以吸引和指导当地美洲原住民高中学生和教师从事生物医学工程和光学。该奖项反映了NSF的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Pre-Transplantation Evaluation of Human Liver Using Polarization-Sensitive Optical Coherence Tomography

使用偏振敏感光学相干断层扫描对人类肝脏进行移植前评估

• DOI: 10.1109/ipc57732.2023.10360789
• 发表时间: 2023
• 期刊: IEEE
• 作者: Yan, Feng;Wang, Chen;Zhang, Qinghao;Selvarai Mercyshalinie, Ebenezer Raj;Yu, Zhongxin;Fung, Kar-Ming;Tang, Qinggong
• 通讯作者: Tang, Qinggong

Epidural needle guidance using a forward-view polarization-sensitive optical coherence tomography probe

使用前视偏振敏感光学相干断层扫描探头的硬膜外针引导

• DOI: 10.1117/12.3005243
• 发表时间: 2024
• 期刊: SPIE
• 作者: Wang, Chen;Liu, Yunlong;Calle, Paul;Zhang, Qinghao;Yan, Feng;Selvaraj Mercyshalinie, Ebenezer Raj;Fung, Kar-Ming;Chen, Sixia;Pan, Chongle;Tang, Qinggong
• 通讯作者: Tang, Qinggong

Optical coherence tomography for multicellular tumor spheroid category recognition and drug screening classification via multi-spatial-superficial-parameter and machine learning

• DOI: 10.1364/boe.514079
• 发表时间: 2024-04-01
• 期刊: BIOMEDICAL OPTICS EXPRESS
• 影响因子: 3.4
• 作者: Yan，Feng;Mutembei，Bornface;Tang，Qinggong
• 通讯作者: Tang，Qinggong

Polarization-sensitive optical coherence tomography for renal tumor detection in ex vivo human kidneys

用于离体人肾肾肿瘤检测的偏振敏感光学相干断层扫描

• DOI: 10.1016/j.optlaseng.2023.107900
• 发表时间: 2024
• 期刊: Optics and Lasers in Engineering
• 影响因子: 4.6
• 作者: Yan, Feng;Wang, Chen;Yan, Yuyang;Zhang, Qinghao;Yu, Zhongxin;Patel, Sanjay G.;Fung, Kar-Ming;Tang, Qinggong
• 通讯作者: Tang, Qinggong