CAREER: Water-Soluble Metallofullerene Derivatives with Defined Structures and Tailorable Functions

职业：具有明确结构和可定制功能的水溶性金属富勒烯衍生物

• 批准号: 2238629
• 负责人: Jianyuan Zhang
• 金额: $ 70万
• 依托单位: Rutgers University New Brunswick
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2238629&HistoricalAwards=false
• 关键词: CAREER; Water; Soluble; Metallofullerene; Derivatives

WIth support from the Macromolecular, Supramolecular, and Nanochemistry (MSN) Program of the Division of Chemistry, Jianyuan Zhang of Rutgers, The State University of New Jersey and his team will synthesize and structurally characterize water soluble endohedral metallofullerenes (EMFs) and explore their potential utility. EMFs are nanometer-sized soccer ball-shaped carbon molecules that encapsulate metal ions within their cages. Electronic, energy, quantum materials, catalysis, electronics, and biotechnologies are potential applications where EMFs show promise. However, realizing their full potential will require a better understanding of their behavior in aqueous solution. Typical approaches to making water-soluble EMF derivatives do not yield structurally defined molecules; they invariably disrupt the structure of the EMF cage and downgrade its electronic properties. This project will use a modular synthetic approach to create a family of water-soluble EMFs with precisely defined structures and study the correlation between their structural parameters and electro-optic properties. In the course of conducting this project, students will be trained in a multidisciplinary research environment. Active learning techniques with real world experiments that are integrated with the research results will be developed. Outreach activities targeting a diverse population in local community colleges will be carried out to introduce economically disadvantaged and underrepresented students future career paths in science.This project will utilize a modular “metallobuckytrio” (MBT) platform that was recently developed in the laboratory of the principal investigator. The MBT platform, which consists of two metallofullerenes covalently bonded to one C60 fullerene, allows the synthesis of a family of structurally defined water-soluble EMF derivatives with desirable properties via judicious selection of ligands. Three research aims will be pursued. In Aim 1, saccharide-functionalized ligands will be introduced to enhance the T1 relaxivity of gadolinium (Gd) MBTs for the next-generation MRI contrast agents. In Aim 2, porphyrin-functionalized ligands will be introduced and photo-induced charge separation and recombination processes of the resulting porphyrin-fullerene tridecads will be investigated. In Aim 3, dye-functionalized ligands will be introduced to form synergistic photosensitizers with potential long term scientific impact in photodynamic therapy (PDT).This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

在化学系大分子、超分子和纳米化学（MSN）项目的支持下，新泽西州立大学的Jianyuan Zhang和他的团队将合成和结构表征水溶性内嵌金属富勒烯（EMF），并探索它们的潜在用途。电磁场是纳米大小的足球形状的碳分子，将金属离子封装在它们的笼子里。 电子，能源，量子材料，催化，电子和生物技术是电磁场显示前景的潜在应用。然而，实现其全部潜力将需要更好地了解其在水溶液中的行为。制备水溶性EMF衍生物的典型方法不产生结构上确定的分子;它们总是破坏EMF笼的结构并降低其电子性质。该项目将使用模块化合成方法来创建具有精确定义结构的水溶性EMF家族，并研究其结构参数与电光特性之间的相关性。在进行这个项目的过程中，学生将在多学科研究环境中接受培训。将开发与研究结果相结合的真实的世界实验的主动学习技术。 将在当地社区学院开展针对不同人群的外联活动，介绍经济困难和代表性不足的学生未来在科学领域的职业道路，该项目将利用首席研究员实验室最近开发的模块化“metallobuckytrio”（MBT）平台。 MBT平台，它由两个金属富勒烯共价键合到一个C60富勒烯，允许通过明智地选择配体合成一个家庭的结构定义的水溶性EMF衍生物具有理想的性能。 三个研究目标将被追求。在目标1中，将引入糖官能化配体以增强用于下一代MRI造影剂的钆（Gd）MBT的T1弛豫率。目标二是引入卟啉功能化配体，研究卟啉-富勒烯十三配体的光诱导电荷分离和复合过程。在目标3中，将引入染料官能化配体以形成协同光敏剂，其在光动力疗法（PDT）中具有潜在的长期科学影响。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估而被认为值得支持。