C1 Building Blocks: Industrial Production of Water-Soluble Boron-Based Chromophores for Bio-Imaging Applications

我们最近重新利用现成的氰化硼氢化钠来制造新一代化学稳定的荧光含硼杂环。这项基础技术发表在JACS的一篇论文中，随后获得了专利。我们委托了Adventus Partners的技术评估报告，并根据对我们想法的反馈，努力在我们提出的工作计划中解决行业需求。这个里程碑式项目的主要目标是开发一种强大的方法来获取新型荧光团，用于流式细胞术、超分辨率显微镜和荧光显微镜的下游应用。我们的平台技术，称为C1Tech，强调中心sp2杂化碳原子对于在战略位置上构建具有高度可调的硼荧光杂环的战略意义。总部位于加拿大的Brilliant Matters将是这项技术的主要接受者。Brilliant Matters对用于材料和生物成像应用的发色团构建的含硼构建块的商业化感兴趣。我们还确定了MilliporeSigma作为这项新技术的另一个受体，以便将我们的发现推向市场。MilliporeSigma是化学试剂领域的国际制造领导者，长期致力于将我们实验室发现的试剂商业化。他们已经有了一个完全致力于Yudin实验室两性构建模块的门户网站，我们期望会有一个额外的门户网站，根据拟议的计划开发杂环和材料。

We recently repurposed readily available sodium cyanoborohydride towards making a new generation of chemically stable fluorescent boron-containing heterocycles. The foundational technology was captured in a JACS paper and was subsequently patented. We commissioned a technology assessment report from Adventus Partners and, on the basis of the obtained feedback to our ideas, endeavoured to address the demands of industry in our proposed work plan. The main objective of this milestone-driven project is to develop a robust methodology to access novel fluorophores for their downstream use in flow cytometry, super-resolution microscopy, and fluorescence microscopy. Our platform technology, called C1Tech, stresses the strategic significance of the central sp2-hybridized carbon atom for the construction of highly tunable fluorescent heterocycles equipped with boron at a strategic position.Canadian-based Brilliant Matters will be the main receptor of this technology. Brilliant Matters is interested in commercialization of boron-containing building blocks for the construction of chromophores for materials and bioimaging applications. We have also identified MilliporeSigma as another receptor of this novel technology in order to market the results of our findings. MilliporeSigma, an international manufacturing leader in the area of chemical reagents, has shown a long-standing commitment to commercializing reagents discovered in our laboratories. They already have a web portal entirely dedicated to amphoteric building blocks from the Yudin lab and it is our expectation that there will be an additional portal to heterocycles and materials developed according to the proposed plan.