SBIR Phase II: Incorporating High Dielectric Constant Materials into clinical imaging: A Novel Approach for Accelerating 1.5T Magnetic Resonance Imaging (MRI)

SBIR II 期：将高介电常数材料纳入临床成像：加速 1.5T 磁共振成像 (MRI) 的新方法

• 批准号: 2242209
• 负责人: Sebastian Rupprecht
• 金额: $ 99.81万
• 依托单位: HYQ RESEARCH SOLUTIONS, LLC
• 依托单位国家: 美国
• 项目类别: Cooperative Agreement
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2242209&HistoricalAwards=false
• 关键词: SBIR; Phase; II; Incorporating; Dielectric

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase II project is to provide the basis for advancing magnetic resonance imaging (MRI) hardware solutions for ultra-fast image acquisition. The proposed effort will target clinical MRI scanners where there is limited MRI access by a large patient population. Long scan times reduce the efficiency of radiology department processes and increase the overall cost to clinics and patients. A successful solution which decreases scan times by half will provide improved patient access and care, especially with regard to measuring metabolic activities, brain activity, and cognition.This Small Business Innovation Research Phase II project will develop high resolution MRI as a powerful tool for understanding metabolic activity in humans and animals. High dielectric constant (HDC) materials provide a low impedance pathway between the patient and magnetic coil of the MRI. The goal of this project is to increase the signal-to-noise ratio of the MRI by over 50%, thereby cutting the scan time by half. The HDC materials will have an immediate impact on animal and human behavior studies where neuroscientists are using MRI techniques to monitor brain activity and cognition. An integrated development approach includes electromagnetic simulation, ceramic processing, and phantom testing. A working prototype will be tested in clinical MRI scanners thus creating an innovative ecosystem comprised of original equipment manufacturers, hospitals, and researchers with clinical experience.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这项小型企业创新研究（SBIR）II期项目的更广泛的影响/商业潜力是为超快速图像获取的磁共振成像（MRI）硬件解决方案提供基础。拟议的努力将针对临床MRI扫描仪，在该临床MRI扫描仪中，大量患者群体的MRI访问有限。长时间的扫描时间降低了放射学部门的效率，并增加了诊所和患者的总体成本。成功的解决方案将扫描时间减少一半将提供改善的患者访问和护理，尤其是在衡量代谢活动，大脑活动和认知方面。这项小型企业创新研究阶段II阶段项目将开发高分辨率MRI，作为了解人类和动物代谢活动的有力工具。高介电常数（HDC）材料在MRI的患者和磁管之间提供了低阻抗途径。该项目的目的是将MRI的信噪比增加50％以上，从而将扫描时间缩短了一半。 HDC材料将对动物和人类行为研究产生直接影响，其中神经科学家正在使用MRI技术来监测大脑活动和认知。 综合开发方法包括电磁模拟，陶瓷加工和幻影测试。 工作原型将在临床MRI扫描仪中进行测试，从而创建一个具有临床经验的原始设备制造商，医院和研究人员组成的创新生态系统。该奖项反映了NSF的法定任务，并被认为是值得通过基金会的知识分子和广泛影响的评估来通过评估来获得支持的。