RII Track-1: Building Capacity across Iowa to Meet Human Needs from Things that Grow
RII Track-1:在爱荷华州进行能力建设,以满足人类对生长物的需求
基本信息
- 批准号:2242763
- 负责人:
- 金额:$ 2000万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Cooperative Agreement
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-08-01 至 2028-07-31
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
The vision of the "Building Capacity across Iowa to Meet Human Needs from Things that Grow" (“Chemurgy 2.0”) project is for Iowa to become an advanced biomanufacturing leader by adapting and modernizing the concept of “chemurgy” – i.e., applied chemistry with a focus on producing industrial products from agricultural material. The project will advance this vision by building and integrating research capacity in biosciences and advanced manufacturing, two key areas identified as important to the State of Iowa. Chemurgy 2.0 will focus on the manufacturing of proteins, vaccines and therapeutics; the manufacturing of biochemicals and biofibers; 3D-printing and composite fabrication processes that utilize biochemicals and biofibers; and applications of data science and artificial intelligence. The development of plastics for additive manufacturing, fibers for flexible and rigid materials, and proteins for diagnostics and therapeutics will benefit society by providing bio-based and sustainable materials for health and consumer applications. With this project, research infrastructure will be improved not only at Iowa research universities but also at predominantly undergraduate institutions in Iowa. Research experiences and educational opportunities will be provided for preservice teachers and for undergraduates from groups traditionally underrepresented – including first-generation and rural students. Chemurgy 2.0 will be administered by Iowa State University in collaboration with the University of Iowa, the University of Northern Iowa, Dordt University, and Central College of Iowa.The Chemurgy 2.0 research program will build capacity in meeting human needs from things that grow in three thematic areas: (1) Plastics for Additive Manufacturing (PAM), (2) Fibers for Flexible and Rigid materials (FFR), and (3) Proteins for Diagnostics and Therapeutics (PDT). The structure of each thematic area supports a “discover” – “optimize” – “scale-up-to manufacture” pipeline that forms an iterative and interconnected loop spanning from the discovery of bio-inspired building blocks to manufacturing applications. PAM links the biomanufacturing of monomers to the Additive Manufacturing (AM) sector. FFR links biofibers to AM, textiles, and medical product manufacture. PDT focuses on larger bio-derived molecules, such as proteins and cell products, and connects them with diagnostics and therapeutics production. Data science is a cross-cutting theme throughout all focal areas. Overall, Chemurgy 2.0 addresses three intersecting problems: biomanufacturing, which is under-developed in Iowa relative to other sectors; the critical physical and cyberinfrastructure needs for biomanufacutring that are currently lacking; and workforce capacity, which is severely constrained in the state. Chemurgy 2.0 is expected to increase research infrastructure and workforce in the basic and applied science and engineering fields related to biomanufacturing and digital industrial technologies. Data-driven educational interventions and the implementation of outreach activities across the state will increase and diversify the Iowa biomanufacturing workforce. Project-based communications with Iowa residents and beyond will build scientific literacy and understanding of Chemurgy 2.0’s role in achieving advanced biomanufacturing in Iowa.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
“建设爱荷华州的能力,以满足人类对增长的需求”(“化学2.0”)项目的愿景是,通过调整和现代化“化学”的概念,使爱荷华州成为先进的生物制造业的领导者-即,应用化学,重点是从农业材料中生产工业产品。该项目将通过建立和整合生物科学和先进制造业的研究能力来推进这一愿景,这两个关键领域被认为对爱荷华州很重要。Chemurgy 2.0将专注于蛋白质,疫苗和治疗剂的制造;生物化学品和生物纤维的制造;利用生物化学品和生物纤维的3D打印和复合材料制造工艺;以及数据科学和人工智能的应用。用于增材制造的塑料、用于柔性和刚性材料的纤维以及用于诊断和治疗的蛋白质的开发将通过为健康和消费者应用提供生物基和可持续材料而造福社会。通过这个项目,不仅爱荷华州研究型大学的研究基础设施将得到改善,而且爱荷华州主要的本科院校也将得到改善。 研究经验和教育机会将提供给兼职教师和传统上代表性不足的群体的本科生,包括第一代和农村学生。Chemurgy 2.0将由爱荷华州州立大学与爱荷华州大学、北方爱荷华州大学、杜尔特大学和爱荷华州中央学院合作管理。Chemurgy 2.0研究计划将在以下三个主题领域建立满足人类需求的能力:(1)用于增材制造的塑料(PAM),(2)用于柔性和刚性材料的纤维(FFR),以及(3)用于诊断和治疗的蛋白质(PDT)。每个主题领域的结构都支持“发现”-“优化”-“扩大规模到制造”的管道,形成了一个迭代和相互关联的循环,从生物启发的构建模块的发现到制造应用。PAM将单体的生物制造与增材制造(AM)部门联系起来。FFR将生物纤维与AM、纺织品和医疗产品制造联系起来。PDT专注于更大的生物衍生分子,如蛋白质和细胞产物,并将它们与诊断和治疗产品联系起来。数据科学是贯穿所有重点领域的交叉主题。总体而言,Chemurgy 2.0解决了三个交叉问题:生物制造,这是欠发达的爱荷华州相对于其他部门;关键的物理和网络基础设施的需要,目前缺乏生物制造;和劳动力能力,这是严重限制的状态。 Chemurgy 2.0预计将增加与生物制造和数字工业技术相关的基础和应用科学和工程领域的研究基础设施和劳动力。 数据驱动的教育干预措施和在全州范围内开展的推广活动将增加爱荷华州生物制造业的劳动力并使其多样化。 与爱荷华州及其他地区居民的基于项目的交流将建立科学素养,并了解Chemurgy 2.0在爱荷华州实现先进生物制造中的作用。该奖项反映了NSF的法定使命,并被认为值得通过使用基金会的知识价值和更广泛的影响审查标准进行评估来支持。
项目成果
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Laura Jarboe其他文献
Alkaline treatment for detoxification of acetic acid-rich pyrolytic bio-oil for microalgae fermentation: Effects of alkaline species and the detoxification mechanisms
- DOI:
10.1016/j.biombioe.2015.05.007 - 发表时间:
2015-09-01 - 期刊:
- 影响因子:
- 作者:
Xuefei Zhao;Kirsten Davis;Robert Brown;Laura Jarboe;Zhiyou Wen - 通讯作者:
Zhiyou Wen
Laura Jarboe的其他文献
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{{ truncateString('Laura Jarboe', 18)}}的其他基金
Planning: Planning Grant for EPSCOR Chemurgy 2.0 - Advanced Biomanufacturing for Next-Generation, Bio-inspired Products
规划:EPSCOR Chemurgy 2.0 规划拨款 - 下一代仿生产品的先进生物制造
- 批准号:
2207183 - 财政年份:2022
- 资助金额:
$ 2000万 - 项目类别:
Standard Grant
Collaborative Research: Mechanisms for Cell Membrane Damage during Production of Biorenewable Fuels
合作研究:生物可再生燃料生产过程中细胞膜损伤的机制
- 批准号:
1604646 - 财政年份:2016
- 资助金额:
$ 2000万 - 项目类别:
Standard Grant
UNS: Engineering Stable Two- and Three-Component Bacterial Consortia
UNS:工程稳定的二组分和三组分细菌群落
- 批准号:
1511646 - 财政年份:2015
- 资助金额:
$ 2000万 - 项目类别:
Standard Grant
Biological Utilization of Thermolytic Substrates by Bacteria and Microalgae: Addressing Toxicity of Substrate Contaminants
细菌和微藻对热解底物的生物利用:解决底物污染物的毒性
- 批准号:
1133319 - 财政年份:2012
- 资助金额:
$ 2000万 - 项目类别:
Continuing Grant
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