I-Corps: Orthopaedic mortars

I-Corps：矫形砂浆

• 批准号: 2244991
• 负责人: Tanvir Choudhri
• 金额: $ 5万
• 依托单位: Icahn School of Medicine at Mount Sinai
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-12-01 至 2023-11-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2244991&HistoricalAwards=false
• 关键词: Corps; Orthopaedic; mortars

The broader impact/commercial potential of this I-Corps project is based on the development of a vertebral augmentation system that actively prevents cement leakage during operations and utilizes photoactivation to control cement curing and enhance adhesion properties for spine applications. It utilizes ultraviolet curing technology to control cement hardening which enhances adhesion properties for spine applications. This system will combine principles from the field of dentistry that have shown advantageous properties for cement compositions and controlled curing capabilities facilitated by light administration. This I-Corps project seeks the development of technology to improve the treatment of vertebral compression fractures. The technology represents the first bone cement treatment to prevent intraoperative bone cement leakage during minimally invasive percutaneous vertebroplasty and kyphoplasty procedures. Bone cement has various applications outside the field of vertebral augmentation, including growing hip and knee arthroplasty and reconstructive orthognathic procedures. The proposed technology will be used for hip and knee arthroplasty procedures. In addition, this technology may be applicable to the field of craniofacial reconstruction providing new methods and approaches for the industry. This technology is adapted with monomers and components that have been utilized successfully in dental implant surgery or independently validated. The combined technology may establish a novel treatment approach that reduces the incidence of cement leakage and secondary fractures at adjacent levels.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该I-Corps项目更广泛的影响/商业潜力基于椎体加固系统的开发，该系统可在手术期间主动防止骨水泥泄漏，并利用光活化控制骨水泥固化并增强脊柱应用的粘附性能。它利用紫外线固化技术来控制水泥硬化，从而增强脊柱应用的粘合性能。该系统将结合来自牙科领域的联合收割机原理，这些原理已经显示出对于粘固剂组合物的有利性质和通过光施用促进的受控固化能力。这个I-Corps项目寻求技术的发展，以改善椎体压缩性骨折的治疗。该技术代表了在微创经皮椎体成形术和椎体后凸成形术过程中防止术中骨水泥泄漏的第一种骨水泥治疗。骨水泥在椎骨增强领域之外有各种应用，包括生长髋关节和膝关节成形术以及重建正颌手术。申报技术将用于髋关节和膝关节置换术。此外，该技术可能适用于颅面重建领域，为业界提供新的方法和途径。该技术适用于已成功用于牙科种植手术或独立验证的单体和组件。该联合技术可能会建立一种新的处理方法，减少水泥泄漏和邻近水平的二次裂缝的发生率。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。