Collaborative Research: Synthetic microbial consortia for organismal resilience and reproducible ecosystem services in changing environments
合作研究:在不断变化的环境中实现有机体恢复力和可再生生态系统服务的合成微生物群落
基本信息
- 批准号:2300058
- 负责人:
- 金额:$ 29.56万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-07-01 至 2026-06-30
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
As our planet's climate continues to change, finding new approaches to alleviate its impact is crucial. Microbiomes, which consist of smaller organisms making a living on larger species, can affect how their hosts respond to environmental change. This project evaluates whether and how we can assemble synthetic microbiomes to help host species cope with the impacts of environmental change. Due to the enormous diversity of microbial communities, there are numerous ways to engineer synthetic microbiomes, making it difficult to identify the principles that underpin their impacts on host species. The researchers will employ high-throughput techniques to simultaneously evaluate the impacts of different synthetic communities and environmental conditions on plant hosts. The results will expand our understanding of how environmental change alters the impacts of microbes on hosts and how engineered synthetic microbial communities may help hosts adapt to a changing climate. The researchers will actively mentor students from middle school to undergraduate level, create a new Course-Based Undergraduate Research Experience Lab course in the cutting-edge field of synthetic microbiology, and design a backyard research program for under-served middle and high school students to provide training to attract their interest to possible careers in STEM. This study will explore the intersection of different research areas to study the interactions between hosts and microbes, including symbiosis, evolutionary biology, and ecosystem functioning. It will assess how elevated temperatures affect three crucial components of host-microbe interactions: (1) microbe-microbe interactions and their impact on host fitness, (2) functional redundancy and its effect on biodiversity and ecosystem functions, and (3) evolvability during microbiome breeding. To achieve this goal, the researchers will collect duckweed, a widespread aquatic plant, across a temperature gradient, acquire bacteria from duckweeds and other sources, and use these collections in large multifactorial experiments on an automated, high-throughput platform. The collections, results, and experimental methods will contribute to the development of microbial consortia that can enhance organismal and ecosystem resilience in the Anthropocene.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
随着我们地球的气候继续变化,找到新的方法来减轻其影响至关重要。微生物组由以较大物种为生的较小生物组成,可以影响其宿主对环境变化的反应。该项目评估我们是否以及如何组装合成微生物组,以帮助宿主物种科普环境变化的影响。由于微生物群落的巨大多样性,有许多方法可以设计合成微生物组,因此很难确定它们对宿主物种影响的基本原理。研究人员将采用高通量技术,同时评估不同合成群落和环境条件对植物宿主的影响。这些结果将扩大我们对环境变化如何改变微生物对宿主的影响以及工程合成微生物群落如何帮助宿主适应不断变化的气候的理解。研究人员将积极指导从中学到本科的学生,在合成微生物学的前沿领域创建一个新的基于课程的本科生研究体验实验室课程,并为服务不足的初中和高中学生设计一个后院研究计划,以提供培训,吸引他们对STEM可能职业的兴趣。 本研究将探索不同研究领域的交叉点,以研究宿主和微生物之间的相互作用,包括共生,进化生物学和生态系统功能。它将评估温度升高如何影响宿主-微生物相互作用的三个关键组成部分:(1)微生物-微生物相互作用及其对宿主适应性的影响,(2)功能冗余及其对生物多样性和生态系统功能的影响,以及(3)微生物繁殖过程中的进化性。为了实现这一目标,研究人员将收集浮萍,一种广泛分布的水生植物,跨越温度梯度,从浮萍和其他来源获得细菌,并在自动化,高通量平台上将这些集合用于大型多因子实验。该奖项反映了NSF的法定使命,并通过使用基金会的知识价值和更广泛的影响审查标准进行评估,被认为值得支持。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Na Wei其他文献
Structural evolution and electrochemical corrosion behavior of Al–Ti–O amorphous-nanocrystalline composite films deposited by magnetron sputtering
磁控溅射Al-Ti-O非晶-纳米晶复合薄膜的结构演化及电化学腐蚀行为
- DOI:
10.1016/j.tsf.2019.137640 - 发表时间:
2019-12 - 期刊:
- 影响因子:2.1
- 作者:
Shuoshuo Tian;Kang Suna;Hongzhi Cui;Xiang Xie;Xinzhen Wang;Na Wei;Huanhuan Wang;Weiguo Wang;Xiaojie Song;Kezhu Yang - 通讯作者:
Kezhu Yang
Estimates for Weak Solutions to Nonlinear Degenerate Parabolic Systems
非线性简并抛物线系统弱解的估计
- DOI:
- 发表时间:
2017 - 期刊:
- 影响因子:1.4
- 作者:
Na Wei;Xiangyu Ge;Yonghong Wu;Leina Zhao - 通讯作者:
Leina Zhao
Genome duplication effects on functional traits and fitness are genetic context and species dependent: studies of synthetic polyploid <i>Fragaria</i>
基因组复制对功能性状和适应性的影响取决于遗传背景和物种:合成多倍体草莓的研究
- DOI:
- 发表时间:
2020 - 期刊:
- 影响因子:0
- 作者:
Na Wei;Zhaokui Du;Aaron Liston;T. Ashman - 通讯作者:
T. Ashman
Osteogenic differentiation of human periodontal ligament cells after transfection with recombinant lentiviral vector containing follicular dendritic cell secreted protein.
含有滤泡树突状细胞分泌蛋白的重组慢病毒载体转染后人牙周膜细胞的成骨分化。
- DOI:
10.1111/jre.12135 - 发表时间:
2014-10 - 期刊:
- 影响因子:3.5
- 作者:
Lin Xiang;Li Ma;Yao He;Na Wei;Ping Gong - 通讯作者:
Ping Gong
Pollinator niche partitioning and asymmetric facilitation contribute to the maintenance of diversity
传粉者生态位划分和不对称促进有助于维持多样性
- DOI:
10.1101/2020.03.02.974022 - 发表时间:
2020 - 期刊:
- 影响因子:0
- 作者:
Na Wei;Rainee L. Kaczorowski;G. Arceo‐Gómez;Elizabeth M. O’Neill;R. Hayes;T. Ashman - 通讯作者:
T. Ashman
Na Wei的其他文献
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{{ truncateString('Na Wei', 18)}}的其他基金
Collaborative Research: Interactions between Photoreactive 2D Nanomaterials and Biofilms
合作研究:光反应性二维纳米材料与生物膜之间的相互作用
- 批准号:
2225108 - 财政年份:2022
- 资助金额:
$ 29.56万 - 项目类别:
Standard Grant
CAREER: SusChEM: Renewable Biocatalysts for Degradation of Persistent Organic Contaminants Using Synthetic Biology
职业:SusChEM:利用合成生物学降解持久性有机污染物的可再生生物催化剂
- 批准号:
2154345 - 财政年份:2021
- 资助金额:
$ 29.56万 - 项目类别:
Continuing Grant
Collaborative Research: Interactions between Photoreactive 2D Nanomaterials and Biofilms
合作研究:光反应性二维纳米材料与生物膜之间的相互作用
- 批准号:
1929009 - 财政年份:2019
- 资助金额:
$ 29.56万 - 项目类别:
Standard Grant
CAREER: SusChEM: Renewable Biocatalysts for Degradation of Persistent Organic Contaminants Using Synthetic Biology
职业:SusChEM:利用合成生物学降解持久性有机污染物的可再生生物催化剂
- 批准号:
1653679 - 财政年份:2017
- 资助金额:
$ 29.56万 - 项目类别:
Continuing Grant
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