SBIR Phase I: Combating Pathogens, Helios-1 Onsite Universal Detection
SBIR 第一阶段:对抗病原体,Helios-1 现场通用检测
基本信息
- 批准号:2304483
- 负责人:
- 金额:$ 27.5万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-08-01 至 2024-07-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The broader/commercial impact of this Small Business Innovation Research (SBIR) Phase I project is protection against pathogen-related infections. Currently, detection tests for pathological agents are laborious, time-consuming, expensive, and require advanced technical expertise to conduct. The proposed portable, onsite pathogen detector will allow for fast, specific, sensitive, and cost-effective pathogen tests that can be conducted with minimal personnel training and equipment. The solution is intended to be used at healthcare centers, transport nodes, defense facilities, and any other site where the spread of infectious diseases is a possibility. This technology will benefit the population’s health and welfare, by facilitating the implementation of pathogen detection routines that reduce the risk of large-scale infections. Such infections disproportionally affect under-represented groups. The solution will also improve the national defense against bioterrorism, since the proposed technology could be as standard as a typical metal detector used in large, populated venues, on the battlefield protecting troops, or at airports to keep the traveling public safe. The nation’s economic competitiveness may also improve, since the proposed solution could mitigate and even avoid the economic consequences of a health crisis.The proposed project seeks to prove that Matrix Assisted Ionization can be coupled with Ion-Mobility Spectrometry (MAI-IMS) for pathogen detection and identification. The recent pandemic outbreak has demonstrated the necessity of rapid, on-site, and accurate pathogen detection devices. The proposed method is to use the existing IMS technology and modify it to detect pathogens by fabricating a Matrix assisted ionization vault (Helios-1) that overcomes the biomolecule volatility restriction of all current ion mobility spectrometers. A crucial technical hurdle is finding the device's optimal ionization and operational environment. To overcome this challenge, the most similar conditions to mass spectrometry must be found, which will involve experimental tests to determine the adequate environmental conditions and the engineering modifications of the MAI extension chamber to adapt IMS for non-volatile biomolecule detection. Standardize organism sample conditions and protocols are also needed. This challenge represents a critical step to prevent variation caused by the extraction of the sampling procedure. This challenge will be tackled by testing different extraction procedures until they meet the criteria for satisfactory performance. Additionally, machine learning algorithms will be employed for pathogen recognition. All of the above will help prove the feasibility of the proposed MAI-IMS-based pathogen detection and identification platform.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
这个小企业创新研究(SBIR)第一阶段项目的更广泛/商业影响是防止病原体相关感染。目前,对病理因子的检测测试是费力的、耗时的、昂贵的,并且需要先进的技术专长来进行。拟议的便携式现场病原体检测器将允许进行快速、特异、灵敏和具有成本效益的病原体检测,只需最少的人员培训和设备。该解决方案旨在用于医疗中心,运输节点,国防设施以及任何其他可能传播传染病的场所。这项技术将有利于人民的健康和福利,促进执行病原体检测程序,减少大规模感染的风险。 这种感染对代表性不足的群体产生了不良影响。 该解决方案还将改善国家对生物恐怖主义的防御,因为拟议的技术可能与大型人口密集场所,战场保护部队或机场保护旅行公众安全的典型金属探测器一样标准。 国家的经济竞争力也可能得到提高,因为所提出的解决方案可以减轻甚至避免健康危机的经济后果。拟议的项目旨在证明基质辅助电离可以与离子迁移谱(MAI-IMS)结合用于病原体检测和鉴定。最近的大流行爆发表明了快速、现场和准确的病原体检测设备的必要性。所提出的方法是使用现有的IMS技术,并通过制造基质辅助电离室(Helios-1)对其进行修改,以检测病原体,该电离室克服了所有当前离子迁移谱仪的生物分子挥发性限制。一个关键的技术障碍是找到设备的最佳电离和操作环境。为了克服这一挑战,必须找到与质谱法最相似的条件,这将涉及实验测试以确定适当的环境条件和MAI扩展室的工程修改,以使IMS适应非挥发性生物分子检测。还需要标准化生物样品条件和方案。该挑战是防止取样程序提取引起变异的关键步骤。将通过测试不同的浸提程序来应对这一挑战,直到它们符合令人满意的性能标准。此外,机器学习算法将用于病原体识别。以上所有内容将有助于证明拟议的基于MAI-IMS的病原体检测和识别平台的可行性。该奖项反映了NSF的法定使命,并通过使用基金会的知识价值和更广泛的影响审查标准进行评估,被认为值得支持。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Darrell Marshall其他文献
Darrell Marshall的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
相似国自然基金
Baryogenesis, Dark Matter and Nanohertz Gravitational Waves from a Dark
Supercooled Phase Transition
- 批准号:24ZR1429700
- 批准年份:2024
- 资助金额:0.0 万元
- 项目类别:省市级项目
ATLAS实验探测器Phase 2升级
- 批准号:11961141014
- 批准年份:2019
- 资助金额:3350 万元
- 项目类别:国际(地区)合作与交流项目
地幔含水相Phase E的温度压力稳定区域与晶体结构研究
- 批准号:41802035
- 批准年份:2018
- 资助金额:12.0 万元
- 项目类别:青年科学基金项目
基于数字增强干涉的Phase-OTDR高灵敏度定量测量技术研究
- 批准号:61675216
- 批准年份:2016
- 资助金额:60.0 万元
- 项目类别:面上项目
基于Phase-type分布的多状态系统可靠性模型研究
- 批准号:71501183
- 批准年份:2015
- 资助金额:17.4 万元
- 项目类别:青年科学基金项目
纳米(I-Phase+α-Mg)准共晶的临界半固态形成条件及生长机制
- 批准号:51201142
- 批准年份:2012
- 资助金额:25.0 万元
- 项目类别:青年科学基金项目
连续Phase-Type分布数据拟合方法及其应用研究
- 批准号:11101428
- 批准年份:2011
- 资助金额:23.0 万元
- 项目类别:青年科学基金项目
D-Phase准晶体的电子行为各向异性的研究
- 批准号:19374069
- 批准年份:1993
- 资助金额:6.4 万元
- 项目类别:面上项目
相似海外基金
UK involvement in LSST: Phase C (Imperial component)
英国参与 LSST:C 阶段(帝国部分)
- 批准号:
ST/X001326/1 - 财政年份:2025
- 资助金额:
$ 27.5万 - 项目类别:
Research Grant
Phase 2 - Effective and Integrated Chemical Free Robotic Milking
第 2 阶段 - 有效且集成的无化学品机器人挤奶
- 批准号:
10093094 - 财政年份:2024
- 资助金额:
$ 27.5万 - 项目类别:
Collaborative R&D
Net Zero Pathfinder - Phase 2 Manchester
净零探路者 - 第二阶段曼彻斯特
- 批准号:
10095254 - 财政年份:2024
- 资助金额:
$ 27.5万 - 项目类别:
Demonstrator
Phase Averaged Deferred Correction for Multi-Timescale Systems
多时间尺度系统的相位平均延迟校正
- 批准号:
EP/Y032624/1 - 财政年份:2024
- 资助金额:
$ 27.5万 - 项目类别:
Research Grant
Model order reduction for fast phase-field fracture simulations
快速相场断裂模拟的模型降阶
- 批准号:
EP/Y002474/1 - 财政年份:2024
- 资助金额:
$ 27.5万 - 项目类别:
Research Grant
IUCRC Phase I University of Wisconsin-Milwaukee: Center for Concrete Advancement Network (CAN), Lead Site
IUCRC 第一阶段威斯康星大学密尔沃基分校:混凝土进步网络中心 (CAN),主要站点
- 批准号:
2310861 - 财政年份:2024
- 资助金额:
$ 27.5万 - 项目类别:
Continuing Grant
IUCRC Phase III University of Colorado Boulder: Center for Membrane Applications, Science and Technology (MAST)
IUCRC 第三阶段科罗拉多大学博尔德分校:膜应用、科学与技术中心 (MAST)
- 批准号:
2310937 - 财政年份:2024
- 资助金额:
$ 27.5万 - 项目类别:
Continuing Grant
SBIR Phase II: Innovative Two-Phase Cooling with Micro Closed Loop Pulsating Heat Pipes for High Power Density Electronics
SBIR 第二阶段:用于高功率密度电子产品的创新两相冷却微闭环脉动热管
- 批准号:
2321862 - 财政年份:2024
- 资助金额:
$ 27.5万 - 项目类别:
Cooperative Agreement
SBIR Phase I: Industrial-Scale Technology for Drug Development in Mature Human Fat Cells
SBIR 第一阶段:成熟人类脂肪细胞药物开发的工业规模技术
- 批准号:
2322443 - 财政年份:2024
- 资助金额:
$ 27.5万 - 项目类别:
Standard Grant
STTR Phase II: Fabrication and Structural Testing of a 3D Concrete Printed Anchor for Floating Offshore Wind
STTR 第二阶段:用于浮动海上风电的 3D 混凝土打印锚的制造和结构测试
- 批准号:
2333306 - 财政年份:2024
- 资助金额:
$ 27.5万 - 项目类别:
Cooperative Agreement