Halogen Bonding Chromatography

蒙大拿大学化学系的Christopher P. Palmer、Orion Berryman和他们的研究小组，在化学系化学测量和成像项目和促进竞争性研究（EPSCoR）的支持下，正在开发用于液相色谱的新型材料和方法。液相色谱法被许多学科和行业用来测量和确定混合物的化学成分。本研究涉及的液相色谱的日常应用包括食品和药品的质量控制和安全保证、环境分析、临床医学、国防、材料开发和工程。本研究引入了具有广泛科学，社会和经济影响的新材料和方法，使具有不同成分的混合物的分析成为可能，并解决了分离科学中的重要挑战。该项目在国家关键需求领域为具有不同背景的研究生和本科生提供教育、培训和发展机会。本项目正在开发、合成和表征利用卤素键作为相互作用和保留机制的新型和普遍有用的液相色谱固定相材料。卤素键的独特特性，包括供体和受体原子之间的软性互补和高度的方向性，产生了与传统分离方法不同的色谱保留和分离选择性。该项目涉及基于表征良好的卤素键给体的单齿和双齿卤素键给体固定相的合成和表征。Palmer-Berryman合作团队将在液相色谱中表征这些卤素键合固定相的性能和选择性。如果成功，这些研究有可能产生重大影响，有可能扩大卤素键合液相色谱在未来代表性药物、肽和蛋白质的分离和分析中的应用。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

With support from the Chemical Measurement and Imaging Program in the Division of Chemistry and the Established Program to Stimulate Competitive Research (EPSCoR), Christopher P. Palmer, Orion Berryman, and their research groups in the Department of Chemistry at the University of Montana are developing novel materials and approaches for use in liquid chromatography. Liquid chromatography is used by many disciplines and industries to measure and determine the chemical composition of mixtures. Everyday applications of liquid chromatography addressed by this research include quality control and safety assurance of food products and pharmaceuticals, environmental analysis, clinical medicine, defense, and materials development and engineering. This research introduces novel materials and methods with broad scientific, social, and economic impact, enabling the analysis of mixtures with diverse compositions, and addressing important challenges in separation sciences. This project provides education, training, and development opportunities for graduate and undergraduate students with diverse backgrounds in an area of critical national need.This project is developing, synthesizing, and characterizing novel and generally useful liquid chromatographic stationary phase materials that utilize halogen bonding as the interaction and retention mechanism. Distinctive characteristics of halogen bonds, including soft-soft complementarity between the donor and acceptor atom and a high degree of directionality, generate chromatographic retention and separation selectivity that is distinct from traditional separations approaches. The project involves the synthesis and characterization of monodentate and bidentate halogen bond-donating stationary phases based on well-characterized halogen bond donors. The collaborative Palmer-Berryman team will characterize the performance and selectivity of these halogen bonding stationary phases in liquid chromatography. If successful, these studies have the potential to for significant impact, potentially expanding halogen bonding liquid chromatography applications to the separation and analysis of representative pharmaceuticals, peptides, and proteins in the future.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.