Halogen Bonding Chromatography

在化学系化学测量和成像计划和既定的促进竞争研究计划(EPSCoR)的支持下，Christopher P.Palmer、Orion Berryman和他们在蒙大拿大学化学系的研究小组正在开发用于液相色谱的新材料和方法。许多学科和行业都使用液相色谱仪来测量和确定混合物的化学成分。这项研究涉及的液体色谱的日常应用包括食品和药品的质量控制和安全保证、环境分析、临床医学、国防以及材料开发和工程。这项研究介绍了具有广泛的科学、社会和经济影响的新材料和方法，使分析具有不同组成的混合物成为可能，并解决了分离科学中的重大挑战。该项目为国家关键需求领域的不同背景的研究生和本科生提供教育、培训和发展机会。该项目正在开发、合成和表征利用卤素键合作为相互作用和保留机制的新型和通用的液相色谱固定相材料。卤键的独特特性，包括给体和受体原子之间的软-软互补和高度的方向性，产生了有别于传统分离方法的色谱保留和分离选择性。该项目涉及基于表征良好的卤键供体的单齿和双齿卤键供体固定相的合成和表征。合作的Palmer-Berryman团队将在液相色谱中表征这些卤素键合固定相的性能和选择性。如果成功，这些研究有可能产生重大影响，有可能在未来扩大卤素键合液相色谱在代表性药物、多肽和蛋白质的分离和分析中的应用。这一奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

With support from the Chemical Measurement and Imaging Program in the Division of Chemistry and the Established Program to Stimulate Competitive Research (EPSCoR), Christopher P. Palmer, Orion Berryman, and their research groups in the Department of Chemistry at the University of Montana are developing novel materials and approaches for use in liquid chromatography. Liquid chromatography is used by many disciplines and industries to measure and determine the chemical composition of mixtures. Everyday applications of liquid chromatography addressed by this research include quality control and safety assurance of food products and pharmaceuticals, environmental analysis, clinical medicine, defense, and materials development and engineering. This research introduces novel materials and methods with broad scientific, social, and economic impact, enabling the analysis of mixtures with diverse compositions, and addressing important challenges in separation sciences. This project provides education, training, and development opportunities for graduate and undergraduate students with diverse backgrounds in an area of critical national need.This project is developing, synthesizing, and characterizing novel and generally useful liquid chromatographic stationary phase materials that utilize halogen bonding as the interaction and retention mechanism. Distinctive characteristics of halogen bonds, including soft-soft complementarity between the donor and acceptor atom and a high degree of directionality, generate chromatographic retention and separation selectivity that is distinct from traditional separations approaches. The project involves the synthesis and characterization of monodentate and bidentate halogen bond-donating stationary phases based on well-characterized halogen bond donors. The collaborative Palmer-Berryman team will characterize the performance and selectivity of these halogen bonding stationary phases in liquid chromatography. If successful, these studies have the potential to for significant impact, potentially expanding halogen bonding liquid chromatography applications to the separation and analysis of representative pharmaceuticals, peptides, and proteins in the future.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.