Laser-induced graphene composites-based standalone stretchable sweat sensing system for remote health monitoring

基于激光诱导石墨烯复合材料的独立可拉伸汗液传感系统，用于远程健康监测

• 批准号: 2309323
• 负责人: Huanyu Cheng
• 金额: $ 40万
• 依托单位: Pennsylvania State Univ University Park
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-01 至 2026-07-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2309323&HistoricalAwards=false
• 关键词: Laser; induced; graphene; composites; based

Inflammation as a defense mechanism in the body is an immune response, which forms the basis of many physiological and pathological processes. However, certain infections can also cause an overwhelming local/systemic inflammatory response, leading to life-threatening diseases. Because of the association between specific cytokines and infectious diseases, there is significant interest in utilizing cytokine levels as an early marker for infection. While blood collection and sample analysis have been applied in current testing for cytokines, they often involve phlebotomy and complex laboratory equipment. Although invasive real-time measurement of small molecules can be achieved with aptamer-based sensors, continuous, non-invasive, and remote monitoring of cytokine levels cannot be accomplished. There is an unmet need to develop wearable devices for non-invasive, continuous monitoring of inflammatory markers to identify at the earliest possible time individuals who are likely to be infected. The non-invasive measurement of biomarkers with ultralow concentrations from the biofluids (e.g., sweat, interstitial fluids) with complex composition requires high sensitivity and selectivity in the sensors, which is challenging to achieve with most existing devices. The need for complex laboratory equipment and the lack of sustained power supplies makes long-term, real-time monitoring elusive. This project will result in a standalone device can simultaneously provide the required properties of high sensitivity/selectivity, wireless measurement, and sustained power supplies.A grand challenge in wearable devices is to achieve non-invasive, long-term, real-time, wireless measurements with high sensitivity/selectivity for diagnostic confirmation and health monitoring. In pursuit of this goal, the research project will investigate a set of foundational laser-induced graphene composite materials, manufacturing approaches, and device problems to shift the current bulky devices or wearable sensors toward standalone stretchable sweat sensing systems for remote real-time health monitoring. The proposed standalone stretchable device systems will distinguish themselves from existing wearable devices in that they possess soft microfluidic electrochemical sensors with enhanced sensitivity/selectivity for real-time synchronous detection of multiple analytes and sustained power supplies for long-term operation. A combined experimental and modeling research program will 1) elucidate the effect of highly porous 3D nanocomposite electrodes functionalized by aptamers on enhanced sensitivity/selectivity, 2) understand the role of Multiphysics design for stretchable devices under mechanical deformations, and 3) uncover the fundamental mechanisms of nanocomposites-based power supplies for enhanced power performance. Through the synergistic integration of research and educational activities, this project will also provide next-generation engineers and scientists with career development opportunities and relevant skill sets to address grand challenges related to bioelectronics for human health.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

炎症是体内防御机制是一种免疫反应，它构成了许多生理和病理过程的基础。 但是，某些感染也会引起压倒性的局部/系统性炎症反应，从而导致威胁生命的疾病。 由于特定的细胞因子和传染病之间的关联，因此对利用细胞因子水平作为感染的早期标记引起了重大兴趣。 尽管收集血液和样品分析已应用于当前的细胞因子测试中，但它们通常涉及静脉切开术和复杂的实验室设备。 尽管可以通过适体传感器进行连续，无创和远程监测细胞因子水平的侵入性实时测量小分子的侵入性实时测量。 不需要开发可穿戴设备，以对炎症标志物进行非侵入性，连续监测，以尽早识别可能被感染的个人。 从生物流体（例如，汗液，间质流体）具有超高浓度的生物标志物的非侵入性测量，具有复杂组成需要高灵敏度和选择性，这在大多数现有设备中都具有挑战性。 需要复杂的实验室设备和缺乏持续的电源，因此难以捉摸的是长期的实时监控。 该项目将导致独立的设备可以同时提供高灵敏度/选择性，无线测量和持续电源的所需属性。可穿戴设备中的巨大挑战是实现非侵入性，长期，实时，无线测量，具有高灵敏度/选择性，具有高灵敏度/选择性，以实现诊断和健康监测。 为了实现这一目标，该研究项目将研究一组基础激光诱导的石墨烯复合材料，制造方法和设备问题，以将当前的笨重设备或可穿戴的传感器转移到独立的可伸展汗水传感系统上，以进行远程实时健康监测。 拟议的独立可拉伸设备系统将使自己与现有的可穿戴设备区分开，因为它们具有柔软的微流体电化学传感器，具有提高灵敏度/选择性，以实时同步检测多个分析物和持续的电源用于长期运行。 一项结合的实验和建模研究计划将1）阐明通过适体功能功能化的高度多孔3D纳米复合电极对增强灵敏度/选择性的功能化，2）了解在机械变形下可伸展的驱动器的多个物理设计对纳米复合材料供电的基本机制，以实现机械变形的可伸缩式发电剂的作用，以实现基于机械性的机制。 通过研究和教育活动的协同融合，该项目还将为下一代工程师和科学家提供职业发展机会和相关技能，以应对与人类健康的生物电子有关的巨大挑战。该奖项反映了NSF的法定任务，并通过该基金会的知识优点和广泛的影响来评估NSF的法定任务，并被认为是值得的支持。