Laser-induced graphene composites-based standalone stretchable sweat sensing system for remote health monitoring

基于激光诱导石墨烯复合材料的独立可拉伸汗液传感系统，用于远程健康监测

• 批准号: 2309323
• 负责人: Huanyu Cheng
• 金额: $ 40万
• 依托单位: Pennsylvania State Univ University Park
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-01 至 2026-07-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2309323&HistoricalAwards=false
• 关键词: Laser; induced; graphene; composites; based

Inflammation as a defense mechanism in the body is an immune response, which forms the basis of many physiological and pathological processes. However, certain infections can also cause an overwhelming local/systemic inflammatory response, leading to life-threatening diseases. Because of the association between specific cytokines and infectious diseases, there is significant interest in utilizing cytokine levels as an early marker for infection. While blood collection and sample analysis have been applied in current testing for cytokines, they often involve phlebotomy and complex laboratory equipment. Although invasive real-time measurement of small molecules can be achieved with aptamer-based sensors, continuous, non-invasive, and remote monitoring of cytokine levels cannot be accomplished. There is an unmet need to develop wearable devices for non-invasive, continuous monitoring of inflammatory markers to identify at the earliest possible time individuals who are likely to be infected. The non-invasive measurement of biomarkers with ultralow concentrations from the biofluids (e.g., sweat, interstitial fluids) with complex composition requires high sensitivity and selectivity in the sensors, which is challenging to achieve with most existing devices. The need for complex laboratory equipment and the lack of sustained power supplies makes long-term, real-time monitoring elusive. This project will result in a standalone device can simultaneously provide the required properties of high sensitivity/selectivity, wireless measurement, and sustained power supplies.A grand challenge in wearable devices is to achieve non-invasive, long-term, real-time, wireless measurements with high sensitivity/selectivity for diagnostic confirmation and health monitoring. In pursuit of this goal, the research project will investigate a set of foundational laser-induced graphene composite materials, manufacturing approaches, and device problems to shift the current bulky devices or wearable sensors toward standalone stretchable sweat sensing systems for remote real-time health monitoring. The proposed standalone stretchable device systems will distinguish themselves from existing wearable devices in that they possess soft microfluidic electrochemical sensors with enhanced sensitivity/selectivity for real-time synchronous detection of multiple analytes and sustained power supplies for long-term operation. A combined experimental and modeling research program will 1) elucidate the effect of highly porous 3D nanocomposite electrodes functionalized by aptamers on enhanced sensitivity/selectivity, 2) understand the role of Multiphysics design for stretchable devices under mechanical deformations, and 3) uncover the fundamental mechanisms of nanocomposites-based power supplies for enhanced power performance. Through the synergistic integration of research and educational activities, this project will also provide next-generation engineers and scientists with career development opportunities and relevant skill sets to address grand challenges related to bioelectronics for human health.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

炎症作为体内的防御机制是一种免疫反应，它形成了许多生理和病理过程的基础。 然而，某些感染也可能导致压倒性的局部/全身炎症反应，导致危及生命的疾病。 由于特异性细胞因子与感染性疾病之间的关联，利用细胞因子水平作为感染的早期标志物具有重大意义。 虽然血液采集和样本分析已应用于当前的细胞因子测试，但它们通常涉及抽血和复杂的实验室设备。 虽然可以用基于适体的传感器实现小分子的侵入性实时测量，但不能实现细胞因子水平的连续、非侵入性和远程监测。 开发用于非侵入性、连续监测炎症标志物的可穿戴设备以在尽可能早的时间识别可能被感染的个体存在未满足的需求。 非侵入性测量来自生物流体的具有超低浓度的生物标志物（例如，汗液、组织间液），要求传感器具有高的灵敏度和选择性，这对于大多数现有设备来说是具有挑战性的。 由于需要复杂的实验室设备和缺乏持续的电力供应，长期、实时监测变得难以实现。 该项目将导致一个独立的设备可以同时提供所需的高灵敏度/选择性，无线测量和持续的功率消耗。在可穿戴设备的一个巨大的挑战是实现非侵入性，长期，实时，无线测量与高灵敏度/选择性的诊断确认和健康监测。 为了实现这一目标，该研究项目将研究一系列基础激光诱导石墨烯复合材料、制造方法和设备问题，以将当前庞大的设备或可穿戴传感器转向独立的可拉伸汗液传感系统，用于远程实时健康监测。 所提出的独立可拉伸设备系统将与现有的可穿戴设备区分开来，因为它们具有软微流体电化学传感器，其具有增强的灵敏度/选择性，用于实时同步检测多种分析物和长期运行的持续电源。 实验和建模相结合的研究计划将1）阐明由适体功能化的高度多孔3D纳米复合材料电极对增强灵敏度/选择性的影响，2）了解机械变形下可拉伸设备的多物理设计的作用，以及3）揭示基于纳米复合材料的电源的基本机制，以增强电源性能。 通过研究和教育活动的协同整合，该项目还将为下一代工程师和科学家提供职业发展机会和相关技能，以应对与人类健康有关的生物电子学的重大挑战。该奖项反映了NSF的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。