Multilayer Membrane Structures for Protein Separations

摘要建议编号：9811409建议类型：研究人员发起首席研究人员：安德鲁·齐德尼隶属关系：特拉华大学这项拨款是通过化学和运输系统部门界面、运输和分离计划的分离和净化计划子要素授予的。首席研究员是特拉华大学的安德鲁·齐德尼博士。该项目涉及开发用于蛋白质分离的多层膜结构。它基于一个有趣的概念，即通过设计一种膜结构，其顶层具有相当开放的孔结构，底层具有较小的孔结构，可以提高对蛋白质分离的选择性。这项研究将考察浓差极化对物种渗透性的影响，以及膜污染和可清洁性的程度。这些研究将证明使用多层膜分离蛋白质的可行性，为后续优化这些膜结构提供必要的框架，以实际纯化生产高价值蛋白质中遇到的特定蛋白质系统。

Abstract Proposal No: 9811409 Proposal Type: Investigator Initiated Principal Investigator: Andrew Zydney Affiliation: University of Delaware This grant is awarded through the Separations and Purification Program sub-element of the Interfacial, Transport and Separations Program of the Chemical and Transport Systems Division. The principal investigator is Dr. Andrew Zydney at the University of Delaware. The project involves the development multilayer membrane structures for protein separations. It is based on the interesting concept that selectivity to protein separations can be enhanced by designing a membrane structure with a top layer of fairly open pore structure and a bottom layer of smaller pore structure. The research will examine the effects of concentration polarization on species permeability, and the extent of membrane fouling and cleanability. The studies will demonstrate the feasibility of using multilayer membranes for protein separations, providing the necessary framework for the subsequent optimization of these membrane structures for the actual purification of specific protein systems encountered in the production of high value proteins.