Collaborative Research: Bioarchaeology, Osteoimmunology, and Ecoimmunology: Linking Inflammation, Life History Tradeoffs, and Biocultural Change

合作研究：生物考古学、骨免疫学和生态免疫学：将炎症、生活史权衡和生物文化变革联系起来

• 批准号: 2316572
• 负责人: Haagen Klaus
• 金额: $ 14万
• 依托单位: George Mason University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-01 至 2025-07-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2316572&HistoricalAwards=false
• 关键词: Collaborative; Research; Bioarchaeology; Osteoimmunology; Ecoimmunology

The immune system and the skeleton are often viewed as separate parts of our biology. However, recent research has revealed that the skeletal and immune systems interact more than previously appreciated as part of the “osteoimmune” system. Hyperinflammation experienced earlier in life, which can result in chronic inflammation, therefore affects the skeleton as well as other parts of the body. This project examines immune and inflammatory proteins in bone that are markers of this complex relationship between bone and immune function and applies them to questions about biocultural processes in human societies. The project advances knowledge in skeletal biology and bioarchaeology by combining traditional observations of skeletal pathology with proteomic analysis to better identify inflammatory responses that may be shaping human morbidity and mortality in the past and present. The broader impacts of the project include student training, including individuals from groups underrepresented in STEM; curriculum expansion; international research collaborations; and engagement with schools, communities, and the public. Early life biological stress and immune system over-activation are thought to produce cascading effects involving phenotypic plasticity and life history trade-offs that shape predilections for later-life inflammatory and hyperinflammatory phenotypes. This project pursues a cross-disciplinary study of skeletal inflammatory diseases, combining observations of periodontal disease and periosteal reaction with proteomic analyses of at least of four independent inflammatory protein biomarkers (osteocalcin, macrophage inflammatory proteins, leukocyte-derived proteins, and neutrophil-derived proteins) in individuals possessing an inferred hyperinflammatory phenotype. The PIs address biocultural hypotheses about the co-occurrence of pathological processes, the role of early life environments in shaping immune response, and the influence of sociocultural dynamics on human biology.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

免疫系统和骨骼通常被视为我们生物学的独立部分。然而，最近的研究表明，骨骼和免疫系统的相互作用比以前认识到的“骨免疫”系统的一部分。在生命早期经历的过度炎症可能导致慢性炎症，因此会影响骨骼以及身体的其他部位。该项目研究了骨骼中的免疫和炎症蛋白，这些蛋白是骨骼和免疫功能之间复杂关系的标志，并将其应用于人类社会生物文化过程的问题。该项目通过将骨骼病理学的传统观察与蛋白质组学分析相结合，以更好地识别可能在过去和现在塑造人类发病率和死亡率的炎症反应，从而推进骨骼生物学和生物考古学的知识。该项目的更广泛影响包括学生培训，包括来自STEM代表性不足的群体的个人;课程扩展;国际研究合作;以及与学校，社区和公众的接触。生命早期的生物应激和免疫系统过度激活被认为会产生级联效应，涉及表型可塑性和生活史权衡，从而形成对晚年炎症和过度炎症表型的偏好。该项目致力于骨骼炎性疾病的跨学科研究，将牙周病和骨膜反应的观察与至少四种独立的炎症蛋白生物标志物（骨钙素，巨噬细胞炎症蛋白，白细胞衍生蛋白和嗜中性粒细胞衍生蛋白）的蛋白质组学分析相结合，这些蛋白质组学分析在具有推断的高度炎症表型的个体中进行。该PI解决有关病理过程的共同发生的生物文化假说，早期生命环境在塑造免疫反应中的作用，以及社会文化动态对人类生物学的影响。该奖项反映了NSF的法定使命，并已被认为是值得通过使用基金会的智力价值和更广泛的影响审查标准进行评估的支持。