URoL:ASC: Biosensors for Field Detection of Aqueous Heavy Metals: A Collaboration with Native American Communities
URoL:ASC:用于现场检测含水重金属的生物传感器:与美洲原住民社区的合作
基本信息
- 批准号:2318897
- 负责人:
- 金额:$ 300万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-08-15 至 2028-07-31
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
Socio-economically challenged communities have borne the highly disproportionate brunt of environmental degradation associated with extractive industries, especially those associated with production of nuclear weapons and energy production. Dispersal of toxic heavy metals into natural waterways as well as agricultural and domestic water sources is accelerating, especially in arid regions where water resources are scarce. Water users, researchers, and remediation efforts rely on highly specialized and costly centralized laboratory facilities to quantify toxic heavy metals in streams, irrigation canals and domestic water sources. Such analyses are not amenable to home or field-use by either trained or lay personnel, both of which desire access to easy-to-use, highly sensitive methods for field-based detection. This award will develop accessible biosensing systems for convenient detection of toxic heavy metals without the need for centralized laboratory facilities. In doing so, it will benefit from end-to-end consultation with water resource management personnel on critical contaminant sensing needs, efficacy of approaches, and successful deployment strategies. The dire threat posed by highly toxic contaminants in these communities provides a compelling context for recruiting students from some of the most under-represented groups to participate in the research. This project will provide a comprehensive training, education, and outreach program to recruit, train, retain, and return indigenous and economically disadvantaged scientific and engineering talent to benefit their communities. Decades of uranium extraction have left a toxic legacy of heavy metal contamination in water sources in Native American and Indo-Hispanic communities in the arid Southwest. There is a critical need for new technologies that require minimal technical training and can be used to rapidly screen for the presence of these toxicants in the home or the field. Over the past 30 years, in vitro selection methods have been used to generate DNA sequences that bind with high affinity and selectivity to many heavy metal ion species. These reagents can form the basis for highly selective biosensors, but they have not yet been translated for routine application in highly contaminated communities and sites in the vicinity of highly contaminated abandoned mines. This award will develop a simple-to-use, yet highly effective, biosensing technologies for field-use based on these reagents by (i) taking into consideration the guidance from their ultimate user communities, and (ii) by implementing fundamental understanding and innovations garnered through a number of previous grants funded under the auspices of the NSF’s Big Idea to Understand the Rules of Life. This multidisciplinary, multi-institutional, user-directed research project will apply the findings and innovations of these previous fundamental research efforts to develop field-deployable solutions for critical problems of water security in Native American, minority, and low-resource communities.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
在采掘业,特别是与核武器生产和能源生产有关的采掘业造成的环境退化中,社会经济困难的社区首当其冲。有毒重金属扩散到自然水道以及农业和家庭水源的速度正在加快,特别是在水资源稀缺的干旱地区。水资源使用者、研究人员和补救工作依赖高度专业化和昂贵的集中实验室设施来量化溪流、灌溉渠和生活水源中的有毒重金属。这样的分析不适合由受过训练的或外行人员在家中或现场使用,这两者都希望获得易于使用的、高灵敏度的方法用于基于现场的检测。该奖项将开发可访问的生物传感系统,以方便检测有毒重金属,而无需集中实验室设施。在此过程中,它将受益于与水资源管理人员就关键污染物传感需求、方法的有效性和成功的部署战略进行的端到端协商。这些社区中剧毒污染物造成的可怕威胁为招募来自一些代表性最低的群体的学生参与研究提供了一个令人信服的背景。该项目将提供一个全面的培训,教育和推广计划,以招募,培训,保留和返回土著和经济上处于不利地位的科学和工程人才,以造福他们的社区。几十年的铀开采在干旱的西南部美洲原住民和印度-西班牙裔社区的水源中留下了重金属污染的有毒遗产。迫切需要新的技术,这些技术需要最低限度的技术培训,并可用于快速筛选这些有毒物质在家庭或现场的存在。在过去的30年里,体外选择方法已被用于产生DNA序列,结合具有高亲和力和选择性的许多重金属离子物种。这些试剂可以构成高选择性生物传感器的基础,但它们尚未转化为在高度污染的社区和高度污染的废弃矿山附近的地点的常规应用。该奖项将开发一种简单易用,但高效的生物传感技术,用于基于这些试剂的现场使用,通过(i)考虑到其最终用户社区的指导,以及(ii)通过实施基本的理解和创新,这些创新是通过NSF的Big Idea to Understand the Rules of Life资助的一些以前的赠款获得的。这个多学科,多机构,用户导向的研究项目将应用这些以前的基础研究工作的结果和创新,为美洲原住民,少数民族,和低-该奖项反映了NSF的法定使命,并通过使用基金会的知识价值和更广泛的影响审查进行评估,被认为值得支持的搜索.
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Gabriel Lopez其他文献
Analysis of green e-methanol supply costs: Domestic production in Europe versus imports via pipeline and sea shipping
绿色电子甲醇供应成本分析:欧洲国内生产与通过管道及海运进口的比较
- DOI:
10.1016/j.renene.2024.122336 - 发表时间:
2025-03-01 - 期刊:
- 影响因子:9.100
- 作者:
Tansu Galimova;Mahdi Fasihi;Dmitrii Bogdanov;Gabriel Lopez;Christian Breyer - 通讯作者:
Christian Breyer
Liposomal delivery of methylphosphonate antisense oligodeoxynucleotides in chronic myelogenous leukemia.
慢性粒细胞白血病中甲基膦酸反义寡脱氧核苷酸的脂质体递送。
- DOI:
- 发表时间:
1994 - 期刊:
- 影响因子:20.3
- 作者:
A. Tari;Stanley D. Tucker;A. Deisseroth;Gabriel Lopez - 通讯作者:
Gabriel Lopez
Establishing an Integrative Oncology Service: Essential Aspects of Program Development
- DOI:
10.1007/s11912-024-01504-x - 发表时间:
2024-02-15 - 期刊:
- 影响因子:5.000
- 作者:
Judith Lacey;Alissa Huston;Gabriel Lopez;Julia Ruiz Vozmediano;Chun Sing Lam;Santhosshi Narayanan;Weidong Lu;Ursula Wolf;Ishwaria M. Subbiah;Patrick Richard;Ana Maria Lopez;Santosh Rao;Moshe Frenkel - 通讯作者:
Moshe Frenkel
Acupuncture for Cancer-Related Anorexia: a Review of the Current Evidence
- DOI:
10.1007/s11912-021-01067-1 - 发表时间:
2021-05-05 - 期刊:
- 影响因子:5.000
- 作者:
Wenli Liu;Gabriel Lopez;Santhosshi Narayanan;Aiham Qdaisat;Yimin Geng;Shouhao Zhou;Michael Spano;Susan Underwood;Marie G. Eclache;Rony Dev;Shalini Dalal;Eduardo Bruera;Lorenzo Cohen - 通讯作者:
Lorenzo Cohen
From knowledge gaps to technological maturity: A comparative review of pathways to deep emission reduction for energy-intensive industries
- DOI:
10.1016/j.rser.2024.115023 - 发表时间:
2025-02-01 - 期刊:
- 影响因子:
- 作者:
Philipp Diesing;Gabriel Lopez;Philipp Blechinger;Christian Breyer - 通讯作者:
Christian Breyer
Gabriel Lopez的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Gabriel Lopez', 18)}}的其他基金
Synthetic P-bodies: Coupling gene expression and ribonucleoprotein granules in synthetic cell vesicles for sensing and response
合成 P 体:将合成细胞囊泡中的基因表达和核糖核蛋白颗粒偶联以进行传感和响应
- 批准号:
2123465 - 财政年份:2021
- 资助金额:
$ 300万 - 项目类别:
Standard Grant
SBIR Phase I: Development of a Novel Biocontainment/Biosafety Platform Using Synthetic Auxotrophs
SBIR 第一阶段:使用合成营养缺陷型开发新型生物防护/生物安全平台
- 批准号:
2126430 - 财政年份:2021
- 资助金额:
$ 300万 - 项目类别:
Standard Grant
EAGER: Engineered, Smart, Nucleic Acid-Binding, Intrinsically Disordered Proteins to Enable Ubiquitous Detection of Viral Pathogens and Diagnosis
EAGER:工程化、智能、核酸结合、本质无序的蛋白质,可实现病毒病原体的普遍检测和诊断
- 批准号:
2031774 - 财政年份:2020
- 资助金额:
$ 300万 - 项目类别:
Continuing Grant
RoL: Conference: DESYN-C3: An International Conference on Engineering Synthetic Cells and Organelles
RoL:会议:DESYN-C3:工程合成细胞和细胞器国际会议
- 批准号:
1841170 - 财政年份:2018
- 资助金额:
$ 300万 - 项目类别:
Standard Grant
I-Corps: Soft Robotics-Inspired Antifouling Urinary Catheters for Reducing Infection
I-Corps:受软机器人启发的防污导尿管,可减少感染
- 批准号:
1560734 - 财政年份:2015
- 资助金额:
$ 300万 - 项目类别:
Standard Grant
Continuous Acoustic Assembly of Metallic Nanoparticles in Microfluidic Systems
微流体系统中金属纳米颗粒的连续声学组装
- 批准号:
1363483 - 财政年份:2014
- 资助金额:
$ 300万 - 项目类别:
Standard Grant
EAGER: Elastomeric Capture Microparticles for High Sensitivity Biodection
EAGER:用于高灵敏度生物检测的弹性体捕获微粒
- 批准号:
1050176 - 财政年份:2010
- 资助金额:
$ 300万 - 项目类别:
Standard Grant
SENSORS: Multi-Analyte Affinity Micro-Columns with Amplified Multi-Parameter Fluorescence Detection
传感器:具有放大多参数荧光检测功能的多分析物亲和微柱
- 批准号:
0332315 - 财政年份:2003
- 资助金额:
$ 300万 - 项目类别:
Continuing Grant
Fluorescence Lifetime-Based Measurements of Biosensor Arrays Using Closed Loop Auto-Oscillating Systems
使用闭环自动振荡系统对生物传感器阵列进行基于荧光寿命的测量
- 批准号:
0230818 - 财政年份:2002
- 资助金额:
$ 300万 - 项目类别:
Standard Grant
CAREER: Hybrid Material Routes to Porous Amorphous Ceramics with Controlled Microstructure
职业:具有受控微观结构的多孔非晶陶瓷的混合材料路线
- 批准号:
9624841 - 财政年份:1996
- 资助金额:
$ 300万 - 项目类别:
Standard Grant
相似国自然基金
人源氨基酸转运复合体ASC-1-4F2hc的转运机制研究
- 批准号:
- 批准年份:2024
- 资助金额:15.0 万元
- 项目类别:省市级项目
核小体蛋白PML作为E3SUMO连接酶调控ASC炎症小体组装及在痛风疾病中的靶点干预研究
- 批准号:
- 批准年份:2024
- 资助金额:49 万元
- 项目类别:面上项目
基于GSTO1介导ASC去谷胱甘肽化修饰研究四妙丸对高尿酸血症血管内皮功能障碍的作用机制
- 批准号:82305034
- 批准年份:2023
- 资助金额:30 万元
- 项目类别:青年科学基金项目
MAOA通过抑制ASC选择性自噬降解加剧骨关节炎进程及其机制研究
- 批准号:82302731
- 批准年份:2023
- 资助金额:30 万元
- 项目类别:青年科学基金项目
PAD2通过促进ASC瓜氨酸化介导细胞焦亡的机制研究
- 批准号:2023JJ40862
- 批准年份:2023
- 资助金额:0.0 万元
- 项目类别:省市级项目
尿酸介导独立于炎症小体的ASC活化诱导晶状体上皮凋亡的调控机制研究
- 批准号:n/a
- 批准年份:2023
- 资助金额:10.0 万元
- 项目类别:省市级项目
Notch2/Foxo1/ASC信号调控aTreg细胞焦亡抑制变应性鼻炎发生发展
- 批准号:82301274
- 批准年份:2023
- 资助金额:30 万元
- 项目类别:青年科学基金项目
SUMOylation修饰炎症小体中心蛋白ASC调控炎症小体活化及在炎症性肠病中的作用机制研究
- 批准号:82301978
- 批准年份:2023
- 资助金额:30 万元
- 项目类别:青年科学基金项目
基于生殖干细胞诱导解析asc-miR-30d靶向Foxl2调控鲟鱼的雌性性别分化机制
- 批准号:n/a
- 批准年份:2023
- 资助金额:10.0 万元
- 项目类别:省市级项目
CRM1介导ASC出核促进炎症小体活化的机制研究
- 批准号:82371768
- 批准年份:2023
- 资助金额:48 万元
- 项目类别:面上项目
相似海外基金
ASC oligomerization and transmission as an initiating event for protein aggregation in Synucleinopathy Dementias
ASC 寡聚化和传递作为突触核蛋白病痴呆中蛋白质聚集的起始事件
- 批准号:
10665955 - 财政年份:2022
- 资助金额:
$ 300万 - 项目类别:
ASC oligomerization and transmission as an initiating event for protein aggregation in Synucleinopathy Dementias
ASC 寡聚化和传递作为突触核蛋白病痴呆中蛋白质聚集的起始事件
- 批准号:
10687150 - 财政年份:2022
- 资助金额:
$ 300万 - 项目类别:
Synthesis of an ASC-targeting AUTAC/ATTEC
合成 ASC 靶向 AUTAC/ATTEC
- 批准号:
2600644 - 财政年份:2021
- 资助金额:
$ 300万 - 项目类别:
Studentship
Common Pathogenesis Mechanisms of Autoinflammatory Diseases by Inflammasome Adaptor ASC Analysis
通过炎性体接头 ASC 分析自身炎症性疾病的常见发病机制
- 批准号:
20K07339 - 财政年份:2020
- 资助金额:
$ 300万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Regulation of antibody secreting cell (ASC) homeostasis by Ufbp1.
Ufbp1 对抗体分泌细胞 (ASC) 稳态的调节。
- 批准号:
10684925 - 财政年份:2020
- 资助金额:
$ 300万 - 项目类别:
Regulation of antibody secreting cell (ASC) homeostasis by Ufbp1.
Ufbp1 对抗体分泌细胞 (ASC) 稳态的调节。
- 批准号:
10269914 - 财政年份:2020
- 资助金额:
$ 300万 - 项目类别:
Regulation of antibody secreting cell (ASC) homeostasis by Ufbp1.
Ufbp1 对抗体分泌细胞 (ASC) 稳态的调节。
- 批准号:
10469611 - 财政年份:2020
- 资助金额:
$ 300万 - 项目类别:
ASC oligomerization and transmission as an initiating event for protein aggregation in Synucleinopathy Dementias
ASC 寡聚化和传递作为突触核蛋白病痴呆中蛋白质聚集的起始事件
- 批准号:
10153651 - 财政年份:2020
- 资助金额:
$ 300万 - 项目类别:
Regulation of antibody secreting cell (ASC) homeostasis by Ufbp1.
Ufbp1 对抗体分泌细胞 (ASC) 稳态的调节。
- 批准号:
10099811 - 财政年份:2020
- 资助金额:
$ 300万 - 项目类别: