MRI: Track 1 Acquisition of a 600MHz NMR Spectrometer for Research, Teaching, and Outreach

该奖项由主要研究仪器和化学研究仪器项目以及既定的激励竞争性研究计划共同支持。蒙大拿大学正在购买一台600 MHz的核磁共振光谱仪，该光谱仪配备了一个三重共振探头、一个双共振宽带探头、一个可变温度单元和一个自动样品转换器，以支持布鲁斯·鲍勒教授和他的同事克拉拉·布里克纳罗娃、奥里昂·贝里曼、特拉维斯·休斯和丹尼尔·德卡托的研究。该仪器促进了结构生物学、生物物理学、超分子化学、有机化学、无机化学和药物化学等领域的研究。总体而言，核磁共振波谱是化学家用于阐明分子结构的最强大的工具之一。它被用来识别未知物质，表征分子中原子的特定排列，并研究分子在溶液或固体中相互作用的动力学。对于正在进行前沿研究的化学家来说，获得最先进的核磁共振光谱仪是必不可少的。这一工具加强了蒙大拿大学几个系各级学生的教育、研究和教学努力。它将直接影响12个实验室的研究，并将影响两个高级实验室课程和几个研究生课程的学生。蒙大拿州及周边各州的地区性部落学院也将使用这一新仪器。该奖项旨在支持所有级别的研究和教育。600 MHz核磁共振波谱仪与三重共振探头耦合，将用于评估稳定蛋白质的合理突变，并用于研究纤维连接蛋白的结构和动力学。双共振宽带探头将服务于使用氟核磁共振来研究核受体的研究工作。该探针还将通过质子-氟核磁共振相关实验加强对非生物叶状体的研究。变温能力将扩大围绕旨在激活碳氢键的瞬时高价第一排过渡金属络合物的研究范围。该自动进样器将允许使用饱和转移差(STD)核磁共振来高通量地评估配体与蛋白质的相互作用，以阐明与C型凝集素受体的基本配体结合事件。600 MHz核磁共振系统还将为药物化学、天然产品、材料科学和聚合物化学领域的各种用户提供服务。作为对全球氦供应挑战的回应，这台仪器的收购包括一个具有低损耗低温恒温器的超导磁体，减少了机构的氦消耗。这项奖励反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

This award is jointly supported by the Major Research Instrumentation and the Chemistry Research Instrumentation programs, and the Established Program to Stimulate Competitive Research. The University of Montana is acquiring a 600 MHz Nuclear Magnetic Resonance (NMR) spectrometer equipped with a triple-resonance probe, a double-resonance broadband probe, a variable temperature unit, and an automated sample changer to support the research of Professor Bruce Bowler and his colleagues: Klara Briknarova, Orion Berryman, Travis Hughes, and Daniel Decato. This instrument facilitates research in the areas of structural biology, biophysics, supramolecular chemistry, organic chemistry, inorganic chemistry, and medicinal chemistry. In general, NMR spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. This instrument enhances the educational, research, and teaching efforts of students at all levels in several departments at the University of Montana. It will directly impact the research of 12 laboratories and will impact students in two upper division lab courses and several graduate courses. The new instrument will also be available for use by regional tribal colleges in Montana and surrounding states.This award is aimed at supporting research and education at all levels. The 600 MHz NMR spectrometer coupled to the triple-resonance probe will be used for evaluating rational mutations for stabilizing proteins and for studying the structure and dynamics of Fibronectin. The double resonance broadband probe will serve research efforts employing fluorine NMR to study nuclear receptors. This probe will also enhance studies of abiotic foldamers through proton-fluorine NMR correlation experiments. The variable temperature capabilities will expand the scope of the studies surrounding transient high valent first row transition metal complexes designed to activate carbon-hydrogen bonds. The autosampler will permit high throughput evaluations of ligand protein interactions using saturation-transfer difference (STD) NMR elucidating fundamental ligand binding events with C-type Lectin receptors. The 600 MHz NMR system will also serve a variety of users within the disciplines of medicinal chemistry, natural products, materials science, and polymer chemistry. In response to global helium supply challenges, the acquisition of this instrument includes a superconducting magnet with a low loss cryostat reducing the institution’s consumption of helium.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.