PFI (MCA): Modeling the Transport of Pharmaceutical Agents Across the Placental Barrier

PFI (MCA)：模拟药物穿过胎盘屏障的运输

• 批准号: 2321975
• 负责人: Nicole Hashemi
• 金额: $ 35万
• 依托单位: Iowa State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2026-08-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2321975&HistoricalAwards=false
• 关键词: PFI; MCA; Modeling; Transport; Pharmaceutical

The broader impact/commercial potential of this Partnerships for Innovation – Mid Career Advancement (PFI-MCA) project lies in an innovative approach and platform technology – integrating 3D cell culture, sensing, and imaging. This system will further enable understanding of physiological processes and can be personalized for each expecting mother using their stem cells, leading to higher accuracy in testing for the transport rate of specific compounds and setting safe exposure levels. The successful completion of this project will lead to an economical and physiologically relevant tool that accommodates testing of a larger number of compounds, facilitates high-throughput screening and rapid data collection, and thus ensures market potential for this technology.The proposed project presents a paradigm shift from the approach currently used to study the transport of pharmaceutical drugs through the placental barrier and their effects on the developing placenta. This platform will replicate the physiological matrix mechanics, hemodynamics, and compound’s ability to permeate through the placental barrier, which will enable quantitative studies to be performed on a vast range of pharmaceuticals to understand their interactions, including transport through the vasculature, and translocation across the placental barrier to diffuse into the fetal blood stream. Furthermore, the system can ultimately be personalized for each expecting mother using their stem cells. This could lead to higher accuracy in testing the transport rate of certain compounds while reducing the cost and enabling real-time monitoring and rapid data collection. Collectively, the proposed technology enables the understanding of critical metabolic and inflammatory processes in the placenta, laying the foundation for its potential commercialization in the future.This project is jointly funded by the Partnerships for Innovation program and the Established Program to Stimulate Competitive Research (EPSCoR).This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这一创新伙伴关系-职业中期发展(PFI-MCA)项目的更广泛影响/商业潜力在于一种创新的方法和平台技术-集成了3D细胞培养、传感和成像。该系统将进一步促进对生理过程的了解，并可使用干细胞为每个怀孕母亲个性化，从而在测试特定化合物的传输速率和设定安全暴露水平方面具有更高的准确性。该项目的成功完成将带来一种经济的和生理上相关的工具，可以测试更多的化合物，促进高通量筛选和快速数据收集，从而确保这项技术的市场潜力。拟议的项目代表了与目前用于研究药物通过胎盘屏障的运输及其对发育中的胎盘的影响的方法的范式转变。该平台将复制生理基质力学、血流动力学和化合物通过胎盘屏障的能力，这将使人们能够对广泛的药物进行定量研究，以了解它们之间的相互作用，包括通过血管系统的转运，以及跨越胎盘屏障扩散到胎儿血液中的移位。此外，该系统最终可以为每个使用干细胞的怀孕母亲个性化。这可以提高测试某些化合物的传输速率的准确性，同时降低成本，实现实时监测和快速数据收集。总的来说，建议的技术使人们能够了解胎盘中的关键新陈代谢和炎症过程，为其未来的潜在商业化奠定基础。该项目由创新伙伴计划和既定的刺激竞争研究计划(EPSCoR)联合资助。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。