CAREER:Sound Production by Flow Induced Elastic Wave with Application to Human Phonation

职业：流感应弹性波发声及其在人类发声中的应用

• 批准号: 2328040
• 负责人: Xudong Zheng
• 金额: $ 51.35万
• 依托单位: Rochester Institute of Tech
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-10-01 至 2023-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2328040&HistoricalAwards=false
• 关键词: CAREER; Sound; Production; Flow; Induced

This research aims to understand the role of the movement of waves through the mucosa of the larynx (voice box) during phonation (the formation of sounds). The mucosal wave is the flow-induced elastic wave that propagates in the superficial layer of the vocal fold. Through the wave motion, it controls the glottal air pulses, which form the primary sound source of the voice. Yet, the fundamental questions of how vocal fold biomechanics and flow loading determine the mucosal wave properties, how the mucosal wave properties affect the glottal flow dynamics, and how the flow dynamics determine the voice outcome, remain elusive. This research aims to answer these questions through an integrated computational study. A high fidelity computational model will be developed that describes voice production in all its complexity, including neuro-muscular stimulation, glottal aerodynamics, flow induced vocal fold vibrations, acoustics and their highly complex nonlinear interactions. The computer model will be validated against experimental data that has previously been collected from in vivo canine specimens. The cause-effect relationship between the mucosal wave properties, glottal flow dynamics and voice outcome will be systematically and quantitatively studied through parametric studies. This research will greatly advance the current state of knowledge regarding voice production, including how voice is controlled. This knowledge will allow better understand how we use and control our voice. It will also enable development of diagnosis metrics for mucosal wave related voice diseases, determine the adjustments to the vocal folds to restore or improve a damaged voice, and predict the outcome of the adjustment. It can also help people who use their voices excessively (e.g. teachers, telemarketers) by providing them with the knowledge for how to efficiently use and control their voices, with the goal of avoiding damage. Strong collaborations with the University of Maine Communications & Speech Disorders Department will include the development of multidisciplinary courses focusing on speech and the introduction of the developed voice simulator into the educational and training program for future practitioners in speech pathology as well as education for speech disorder patients.The mucosal wave propagates through the superficial layers of the vocal fold. It is induced by flow and controls the movement of air through the glottis, which then produces the sound during speech and other forms of phonation. More importantly, its strong interaction of this elastic wave with the glottal flow generates complex flow patterns and morphologies, such as dynamic flow separation, intraglottal vortices, vortex shedding, shear layer instabilities and transitions to turbulence. All of these factors significantly enhance the complexity inherent to the voice. The foundational questions that will be addressed focus on vocal fold biomechanics, glottal flow dynamics, and how the dynamics of the wave affect the production of the voice. This will be addressed through an integrated multiphysics computational study. The integrated educational component involves strong collaboration with the Department of Communication and Speech Disorders. A multidisciplinary course will be developed to educate both speech pathologists and engineers on the underlying biomechanics of speech. In addition, the simulation system developed will be directly employed in the training of speech pathologists and in the education of individuals suffering from speech disorders.

本研究旨在了解声波在发声（声音的形成）过程中通过喉部（声带）粘膜的运动所起的作用。粘膜波是一种在声带浅层传播的流致弹性波。通过声波运动，控制声门空气脉冲，形成声音的主要声源。然而，声带生物力学和血流负荷如何决定粘膜波特性，粘膜波特性如何影响声门流动动力学，以及流动动力学如何决定声音结果等基本问题仍然难以捉摸。本研究旨在通过综合计算研究来回答这些问题。将开发一个高保真计算模型，描述声音产生的所有复杂性，包括神经肌肉刺激，声门空气动力学，流诱导声带振动，声学及其高度复杂的非线性相互作用。计算机模型将与先前从体内犬标本中收集的实验数据进行验证。通过参数化研究，系统定量地研究粘膜波特性、声门血流动力学与语音输出之间的因果关系。这项研究将极大地推进当前关于声音产生的知识，包括声音是如何被控制的。这些知识将使我们更好地理解我们是如何使用和控制我们的声音的。此外，还将开发与粘膜波相关的声音疾病的诊断指标，确定为恢复或改善受损的声音而对声带进行的调整，并预测调整的结果。它还可以帮助过度使用声音的人（例如教师、电话推销员），向他们提供如何有效使用和控制声音的知识，以避免伤害。与缅因大学通信和语言障碍系的紧密合作将包括开发多学科课程，重点是语言，并将开发的语音模拟器引入语言病理学未来从业人员的教育和培训计划，以及语言障碍患者的教育。粘膜波通过声带的浅层传播。它是由气流引起的，控制空气通过声门的运动，然后在讲话和其他形式的发音中产生声音。更重要的是，这种弹性波与声门流动的强烈相互作用产生了复杂的流动模式和形态，如动态流动分离、声门内涡旋、涡旋脱落、剪切层不稳定和向湍流过渡。所有这些因素都大大增加了声音固有的复杂性。基础问题将集中在声带生物力学，声门流动动力学，以及声波的动力学如何影响声音的产生。这将通过一个集成的多物理场计算研究来解决。综合教育部分涉及与沟通和语言障碍系的强有力合作。将开设多学科课程，对语言病理学家和工程师进行语言生物力学基础方面的教育。此外，开发的模拟系统将直接用于语言病理学家的培训和语言障碍患者的教育。

项目成果

Effects of cricothyroid and thyroarytenoid interaction on voice control: Muscle activity, vocal fold biomechanics, flow, and acoustics

环甲腺和甲杓相互作用对声音控制的影响：肌肉活动、声带生物力学、流动和声学

• DOI: 10.1121/10.0005275
• 发表时间: 2021
• 期刊: The Journal of the Acoustical Society of America
• 作者: Movahhedi, Mohammadreza;Geng, Biao;Xue, Qian;Zheng, Xudong
• 通讯作者: Zheng, Xudong

Coupling between a fiber-reinforced model and a Hill-based contractile model for passive and active tissue properties of laryngeal muscles: A finite element study

纤维增强模型和基于 Hill 的收缩模型之间的耦合，用于喉部肌肉的被动和主动组织特性：有限元研究

• DOI: 10.1121/1.5055564
• 发表时间: 2018
• 期刊: The Journal of the Acoustical Society of America
• 作者: Pham, Ngoc;Xue, Qian;Zheng, Xudong
• 通讯作者: Zheng, Xudong

A computational framework for patient-specific surgical planning of type 1 thyroplasty

1 型甲状腺成形术患者特异性手术计划的计算框架

• DOI: 10.1121/10.0009084
• 发表时间: 2021
• 期刊: JASA Express Letters
• 影响因子: 1
• 作者: Movahhedi, Mohammadreza;Geng, Biao;Xue, Qian;Zheng, Xudong
• 通讯作者: Zheng, Xudong

A three-dimensional vocal fold posturing model based on muscle mechanics and magnetic resonance imaging of a canine larynx

• DOI: 10.1121/10.0001093
• 发表时间: 2020-04-01
• 期刊: JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA
• 影响因子: 2.4
• 作者: Geng Biao;Pham Ngoc;Zheng Xudong
• 通讯作者: Zheng Xudong

Vocal fold vibration mode changes due to cricothyroid and thyroarytenoid muscle interaction in a three-dimensional model of the canine larynx

• DOI: 10.1121/10.0005883
• 发表时间: 2021-08-01
• 期刊: JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA
• 影响因子: 2.4
• 作者: Geng, Biao;Movahhedi, Mohammadreza;Zheng, Xudong
• 通讯作者: Zheng, Xudong