I-Corps: Cooling catheter to improve intracerebral hemorrhage recovery

I-Corps：冷却导管改善脑出血恢复

• 批准号: 2330117
• 负责人: Christopher Kellner
• 金额: $ 5万
• 依托单位: Icahn School of Medicine at Mount Sinai
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-15 至 2024-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2330117&HistoricalAwards=false
• 关键词: Corps; Cooling; catheter; improve; intracerebral

The broader impact/commercial potential of this I-Corps project is the development of a cooling device to improve recovery after intracerebral hemorrhage (ICH). ICH is a devastating disease that occurs spontaneously or because of a wide range of pathologies and afflicts approximately 70,000 individuals per year in the US alone. Mechanical stress and destruction of cerebral tissue due to hematoma formation rapidly follows the hemorrhagic event and is associated with swelling of the neuronal tissue surrounding the site of injury. Studies on the therapeutic role of hypothermia after cardiac arrest and hypoxic brain events suggest a promising role in patients diagnosed with ICH. Unfortunately, currently available methods for decreasing temperature cannot provide a localized, sustained, and rapid cooling effect and have undesirable side effects such as pneumonia and septicemia. The proposed technology may overcome these limitations and provide an effective treatment and improve recovery for ICH patients. This I-Corps project is based on the development of a focal cooling device to treat intracerebral hemorrhage (ICH). The proposed device is placed within the evacuation cavity following minimally invasive endoscopic ICH evacuation. The device may be placed and initiated during surgery, can remain operative for weeks, and can be removed without the need for additional surgery. The proposed approach is fundamentally different from current and traditional therapeutic hypothermia strategies that focus on systemic cooling by creating a device and deployment method that limits the area of temperature modulation to the area of injury and the immediate vicinity. The proposed device maximizes the neuroprotective properties of hypothermia via temperature reduction in the perihematomal region and may limit the complications associated with systemic hypothermia including shivering, coagulopathy, and infection.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该I-Corps项目的更广泛影响/商业潜力是开发一种冷却装置，以改善脑出血（ICH）后的恢复。ICH是一种自发发生或因多种病理而发生的毁灭性疾病，仅在美国每年就有约70，000人受到影响。由于血肿形成导致的脑组织的机械应力和破坏在出血事件之后迅速发生，并且与损伤部位周围的神经元组织的肿胀相关。 对心脏骤停和缺氧性脑事件后低温治疗作用的研究表明，在诊断为ICH的患者中具有很好的作用。不幸的是，目前可用的降低温度的方法不能提供局部、持续和快速的冷却效果，并且具有不期望的副作用，例如肺炎和败血症。 所提出的技术可以克服这些局限性，并为ICH患者提供有效的治疗和改善恢复。这个I-Corps项目是基于治疗脑出血（ICH）的局灶性冷却装置的开发。 申报器械在微创内镜下ICH排空后放置在排空腔内。该装置可以在手术期间放置和启动，可以保持操作数周，并且可以在不需要额外手术的情况下移除。所提出的方法从根本上不同于当前和传统的治疗性低温策略，其通过创建将温度调节区域限制在损伤区域和紧邻区域的设备和部署方法来关注全身冷却。建议的设备通过降低血肿周围区域的温度来最大限度地提高低温的神经保护性能，并可能限制与全身低温相关的并发症，包括颤抖、凝血障碍和感染。该奖项反映了NSF的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。