I-Corps: Cooling catheter to improve intracerebral hemorrhage recovery

I-Corps项目更广泛的影响/商业潜力是开发一种冷却装置，以提高脑出血（ICH）后的恢复。ICH是一种毁灭性的疾病，自发发生或由于广泛的病理，每年仅在美国就折磨着大约7万人。机械应力和脑组织的破坏，由于血肿的形成迅速出血事件，并与周围的神经组织损伤部位的肿胀。对心脏骤停和脑缺氧事件后低温治疗作用的研究表明，在诊断为脑出血的患者中有很好的作用。不幸的是，目前可用的降温方法不能提供局部、持续和快速的降温效果，并且有不良的副作用，如肺炎和败血症。所提出的技术可以克服这些限制，为脑出血患者提供有效的治疗和改善康复。这个I-Corps项目是基于一种局部冷却装置的发展来治疗脑出血（ICH）。所建议的装置放置在微创内镜ICH疏散后的疏散腔内。该装置可以在手术期间放置和启动，可以保持工作数周，并且可以在不需要额外手术的情况下移除。所提出的方法与当前和传统的治疗性低温策略有根本的不同，后者通过创造一种设备和部署方法，将温度调节区域限制在损伤区域和邻近区域，从而专注于全身冷却。该装置通过降低血肿周围区域的温度，最大限度地发挥了低温的神经保护特性，并可能限制与全身低温相关的并发症，包括寒战、凝血功能障碍和感染。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

The broader impact/commercial potential of this I-Corps project is the development of a cooling device to improve recovery after intracerebral hemorrhage (ICH). ICH is a devastating disease that occurs spontaneously or because of a wide range of pathologies and afflicts approximately 70,000 individuals per year in the US alone. Mechanical stress and destruction of cerebral tissue due to hematoma formation rapidly follows the hemorrhagic event and is associated with swelling of the neuronal tissue surrounding the site of injury. Studies on the therapeutic role of hypothermia after cardiac arrest and hypoxic brain events suggest a promising role in patients diagnosed with ICH. Unfortunately, currently available methods for decreasing temperature cannot provide a localized, sustained, and rapid cooling effect and have undesirable side effects such as pneumonia and septicemia. The proposed technology may overcome these limitations and provide an effective treatment and improve recovery for ICH patients. This I-Corps project is based on the development of a focal cooling device to treat intracerebral hemorrhage (ICH). The proposed device is placed within the evacuation cavity following minimally invasive endoscopic ICH evacuation. The device may be placed and initiated during surgery, can remain operative for weeks, and can be removed without the need for additional surgery. The proposed approach is fundamentally different from current and traditional therapeutic hypothermia strategies that focus on systemic cooling by creating a device and deployment method that limits the area of temperature modulation to the area of injury and the immediate vicinity. The proposed device maximizes the neuroprotective properties of hypothermia via temperature reduction in the perihematomal region and may limit the complications associated with systemic hypothermia including shivering, coagulopathy, and infection.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.