I-Corps: Deployment of antibacterials as seed treatments

这个I-Corps项目的更广泛的影响/商业潜力是开发技术，通过提供一种种子包衣处理来减轻细菌性穗枯病(BPB)的影响，该处理将在病原体造成整个植物损害之前将其杀死。大米是全球30多亿人的主食。水稻病害影响全世界的水稻生产，因此对全球粮食安全构成重大威胁。在水稻病害中，由伯克霍尔德氏菌引起的白叶枯病问题尤其严重，因为目前还没有有效的方法来控制它。这项技术的部署可能会减少农民因这种疾病造成的产量损失，同时还可以减少与购买和使用无效抗菌化学品相关的成本。这项技术可能会让美国和世界各地的稻农受益。虽然这个项目主要针对水稻上的一种特定的细菌病，但它的影响也有可能扩大到其他作物疾病。这个i-Corps项目是基于开发一种环保和有效的种衣剂来控制白穗病(BPB)。真菌和细菌等微生物引起的植物病害严重影响农业生产力。传统上，真菌植物病害一直由合成杀菌剂控制，这些杀菌剂虽然有效，但对环境构成重大威胁。与真菌疾病相比，目前还没有有效的方法来控制作物中的细菌疾病，主要是因为在作物中使用合成抗生素会增加抗生素耐药性传播给人类细菌病原体的可能性。迫切需要找到既能有效对抗植物病害又不会对人类健康或环境造成不良影响的抗菌剂。水稻白粉病(BPB)已造成世界范围内水稻产量的显著下降。建议的技术是基于环境细菌蛋白假单胞菌PBL3菌株的分泌部分。因为蛋白杆菌PBL3的分泌组分含有多种作用模式的分子混合物，所以细菌产生抗药性的可能性非常小。这项技术有可能提供一种有效、持久、环保和消费者接受的方法来减少大米中的BPB。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

The broader impact/commercial potential of this I-Corps project is the development of technology to alleviate the impact of Bacterial Panicle Blight (BPB) by providing a seed coating treatment that will kill the pathogen before it can cause damage throughout the plant. Rice is a food staple for more than 3 billion people around the globe. Rice diseases affect rice production worldwide, and as a result, represent a significant threat to global food security. Among rice diseases, Bacterial Panicle Blight, caused by the pathogen Burkholderia glumae, is particularly problematic as there are not effective methods to control it. The deployment of this technology may reduce yield loss to farmers due to this disease, while also reducing the costs associated with the purchase and use of antibacterial chemicals that are not effective. This technology may benefit rice farmers in the United States and across the world. Although this project focuses on a specific bacterial disease in rice, it is possible that its impact can be expanded to other crop diseases.This I-Corps project is based on the development of an environmentally-friendly and effective seed coating treatment to control Bacterial Panicle Blight (BPB). Plant diseases caused by microorganisms such as fungi and bacteria significantly affect agricultural productivity. Traditionally, fungal plant diseases have been controlled by synthetic fungicides that while effective, pose significant threat to the environment. In contrast to fungal diseases, effective methods to control bacterial diseases in crops are unavailable, mostly because the use of synthetic antibiotics in crops can increase the likelihood that antibiotic resistance can be transmitted to human bacterial pathogens. There is a critical need to find antibacterials effective against plant diseases without detrimental effects to human health or the environment. Bacterial Panicle Blight (BPB) has significantly decreased rice production worldwide. The proposed technology is based on the secreted fraction of the environmental bacterium Pseudomonas protegens strain PBL3. Because the P. protegens PBL3 secreted fraction contains a mixture of molecules with diverse modes of action, the likelihood that bacteria develop resistance is very small. This technology has the potential to provide an effective, long-lasting, environmentally-friendly and consumer-accepted method of reducing BPB in rice.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.