I-Corps: Deployment of antibacterials as seed treatments

该 I-Corps 项目更广泛的影响/商业潜力是开发技术，通过提供种衣处理来减轻细菌性穗枯病 (BPB) 的影响，在病原体对整个植物造成损害之前将其杀死。大米是全球超过 30 亿人的主食。水稻病害影响全球水稻生产，因此对全球粮食安全构成重大威胁。在水稻病害中，由病原体穗伯克霍尔德氏菌引起的细菌性穗枯病尤其成问题，因为没有有效的方法来控制它。这项技术的部署可以减少农民因这种疾病而造成的产量损失，同时还可以降低与购买和使用无效抗菌化学品相关的成本。这项技术可能会让美国和世界各地的稻农受益。虽然该项目专注于水稻中的一种特定细菌性疾病，但其影响有可能扩展到其他作物疾病。该 I-Corps 项目基于开发一种环保且有效的种衣处理方法来控制细菌性穗枯病 (BPB)。由真菌和细菌等微生物引起的植物病害严重影响农业生产力。传统上，真菌植物病害是通过合成杀菌剂来控制的，虽然有效，但对环境构成了重大威胁。与真菌病害相比，控制作物细菌性病害的有效方法尚不存在，主要是因为在作物中使用合成抗生素会增加抗生素耐药性传播给人类细菌病原体的可能性。迫切需要找到有效对抗植物病害且不对人类健康或环境产生有害影响的抗菌剂。细菌性穗枯病（BPB）已导致全球水稻产量显着下降。所提出的技术基于环境细菌保护假单胞菌菌株 PBL3 的分泌部分。由于 P. protegens PBL3 分泌级分含有具有不同作用模式的分子混合物，因此细菌产生耐药性的可能性非常小。该技术有潜力提供一种有效、持久、环保且消费者接受的方法来减少大米中的 BPB。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。

The broader impact/commercial potential of this I-Corps project is the development of technology to alleviate the impact of Bacterial Panicle Blight (BPB) by providing a seed coating treatment that will kill the pathogen before it can cause damage throughout the plant. Rice is a food staple for more than 3 billion people around the globe. Rice diseases affect rice production worldwide, and as a result, represent a significant threat to global food security. Among rice diseases, Bacterial Panicle Blight, caused by the pathogen Burkholderia glumae, is particularly problematic as there are not effective methods to control it. The deployment of this technology may reduce yield loss to farmers due to this disease, while also reducing the costs associated with the purchase and use of antibacterial chemicals that are not effective. This technology may benefit rice farmers in the United States and across the world. Although this project focuses on a specific bacterial disease in rice, it is possible that its impact can be expanded to other crop diseases.This I-Corps project is based on the development of an environmentally-friendly and effective seed coating treatment to control Bacterial Panicle Blight (BPB). Plant diseases caused by microorganisms such as fungi and bacteria significantly affect agricultural productivity. Traditionally, fungal plant diseases have been controlled by synthetic fungicides that while effective, pose significant threat to the environment. In contrast to fungal diseases, effective methods to control bacterial diseases in crops are unavailable, mostly because the use of synthetic antibiotics in crops can increase the likelihood that antibiotic resistance can be transmitted to human bacterial pathogens. There is a critical need to find antibacterials effective against plant diseases without detrimental effects to human health or the environment. Bacterial Panicle Blight (BPB) has significantly decreased rice production worldwide. The proposed technology is based on the secreted fraction of the environmental bacterium Pseudomonas protegens strain PBL3. Because the P. protegens PBL3 secreted fraction contains a mixture of molecules with diverse modes of action, the likelihood that bacteria develop resistance is very small. This technology has the potential to provide an effective, long-lasting, environmentally-friendly and consumer-accepted method of reducing BPB in rice.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.