I-Corps: Technology for processing lipoaspirate for plastic surgery and regenerative medicine

I-Corps：用于整形外科和再生医学的脂肪抽吸物处理技术

• 批准号: 2343782
• 负责人: Jered Haun
• 金额: $ 5万
• 依托单位: University of California-Irvine
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-11-15 至 2024-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2343782&HistoricalAwards=false
• 关键词: Corps; Technology; processing; lipoaspirate; plastic

The broader impact/commercial potential of this I-Corps project is the development of a medical device for the processing of liposuction fat as a source of adult stem cells in the body for point-of-care aesthetic and regenerative medicine applications. Fat grafting is one of the most common and versatile surgical procedures performed by plastic and reconstructive surgeons. The proposed device targets point-of-care therapeutics in all aspects of regenerative medicine where autologous stem cells (derived and used within the same person) are required. The proposed device may enable the processing of large and small volumes of fat without the use of harmful chemicals in about 15 minutes. In addition, it is a closed system that is designed to provide reproducible processing to yield the highest quality fat for grafting and therapeutic applications, while reducing operating room time and the need for special equipment or technicians, allowing the surgeon to focus on the patient rather than fat processing. It may be used in applications such as the treatment of osteoarthritis, and diabetic foot ulcers in amputation candidates with severe vascular disease and poor access to care.This I-Corps project is based on the development of a medical device to process and deploy adipose tissue and stem cells for therapeutic applications. The core technologies developed for this platform include a preparation device, which dynamically washes fat tissue to remove tumescent fluid, blood, and other aqueous waste; an emulsification and micronization device, which generates shear forces to break down fat tissue into smaller units; and a filtration device, which removes large adipose fragments and maximizes cell recovery. The goal is to combine all three components into a single-use disposable cartridge that will integrate with a reusable platform to create a tool that decreases procedure time and manpower required in the operating room or clinical setting while improving reliability and clinical outcomes for the surgeon and the patient. Preliminary research has shown that the proposed platform generates a stem cell therapeutic with comparable viability and cell counts to the standards currently used. In addition, data show that the device also enriches stem cell populations critical to tissue recovery at 3 and 4 times the levels of other devices on the market.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该I-Corps项目的更广泛的影响/商业潜力是开发用于处理吸脂脂肪作为体内成年干细胞来源的医疗装置，以进行护理的美学和再生医学应用。 脂肪移植是由塑料和重建外科医生执行的最常见和通用的手术程序之一。 所提出的装置靶向需要自体干细胞（派生和使用同一人）的再生医学各个方面的护理疗法。 所提出的设备可以在大约15分钟内使用有害化学物质的情况下加工大量和少量的脂肪。此外，这是一个封闭的系统，旨在提供可再现的加工，以产生最高质量的脂肪，以用于嫁接和治疗应用，同时减少手术室的时间以及对特殊设备或技术人员的需求，从而使外科医生能够专注于患者而不是脂肪处理。 它可用于治疗骨关节炎的治疗，以及严重血管疾病的截肢候选者中的糖尿病足溃疡。这项I-Corps项目基于开发医疗设备来处理和部署脂肪组织和干细胞用于治疗应用。 为该平台开发的核心技术包括制备装置，该设备可以动态洗涤脂肪组织以去除肿瘤液，血液和其他水性废物。一种乳化和微观化装置，该装置会产生剪切力，以将脂肪组织分解为较小的单位。和一个过滤装置，可去除大型脂肪片段并最大化细胞恢复。 目的是将所有三个组件组合到一次性的一次性一次性墨盒中，该墨盒将与可重复使用的平台集成，以创建一个工具，以减少手术室或临床环境中所需的手术时间和人力，同时改善外科医生和患者的可靠性和临床结果。 初步研究表明，所提出的平台生成具有可比性的干细胞治疗，并且与当前使用的标准相当。 此外，数据还表明，该设备还丰富了市场上其他设备水平至关重要的干细胞种群。该奖项反映了NSF的法定任务，并被认为是值得通过基金会的智力优点评估和更广泛的影响来审查标准的评估值得支持的。