Single viewpoint panoramic imaging technology for colonoscopy

肠镜单视点全景成像技术

• 批准号: 10580165
• 负责人: Rongguang Liang
• 金额: $ 20.92万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-01-01 至 2024-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10580165
• 关键词: Address; Adopted; Adoption; Algorithms; Area; Cancer Etiology; Cessation of life; Colon; Colon Carcinoma; Colonoscopes; Colonoscopy; Color; Complex; Data Analyses; Detection; Development; Diamond; Economic Burden; Engineering; Evaluation; Excision; Goals; Growth; Image; Imaging technology; Incidence; Lesion; Location; Malignant Neoplasms; Methods; Modeling; Morbidity - disease rate; Optics; Patients; Performance; Physicians; Polyps; Precancerous Polyp; Published Comment; Screening for cancer; Screening procedure; Side; Societies; Surface; System; Time; Training; United States; Woman; burden of illness; cancer prevention; clinical practice; contrast imaging; cost; design; experience; fabrication; image processing; imaging capabilities; imaging system; improved; lens; men; mortality; novel; premalignant; prevent; screening

Abstract Colon cancer is a leading cause of cancer death in the United States and worldwide. Colonoscopy is the preferred screening method at an estimated annual cost of about $24 billion in the US. Unfortunately, many lesions are missed because they can remain hidden from view behind folds and flexures of the colon. Current methods of increasing the field of view are ineffective and some are very expensive, preventing the adoption of these methods into clinical practice. In this proposal, we propose to develop a single viewpoint panoramic imaging technology which can provide 360-degree side-view of the colon. The proposed panoramic imaging system consists of an array of imaging systems which share the same viewpoint, addressing the key barrier in reconstructing the panoramic image from multiple imaging systems. We will develop a unique monolithic opto-mechanical design to integrate all subsystems precisely without active alignment. The proposed single viewpoint panoramic imaging system can be either integrated to the new colonoscope so that the colonoscope will have standard forward view and 360- degree panoramic side-view, or built as a snap-on attachment for the current commercial colonoscopes to provide 360-degree panoramic side-view. To demonstrate the imaging capability of the proposed single viewpoint panoramic system, we will first develop and characterize a single viewpoint panoramic attachment for the standard colonoscope, and then evaluate the performance in detecting polyps and compare to a standard colonoscope. The proposed single viewpoint panoramic imaging system will maximize the detection of polyps and substantially reduce the incidence of colon cancer. It will benefit the patients and society in five-fold: reducing incidence of colon cancer, reducing the chance of ‘interval’ cancer, decreasing overall morbidity and mortality, increasing the interval between colonoscopies, and reducing the economic burden of this disease.

摘要 结肠癌是美国和世界范围内癌症死亡的主要原因。结肠镜检查是 首选的筛查方法，在美国估计每年的成本约为240亿美元。不幸的是，许多人 由于病变可能隐藏在结肠的褶皱和弯曲后面，因此未发现病变。当前 增加视场的方法无效，有些方法非常昂贵，阻碍了采用 将这些方法应用于临床实践。 在这个方案中，我们建议开发一种单视点全景成像技术，该技术可以提供 结肠的360度侧视图。建议的全景成像系统由一系列成像阵列组成 具有相同观点的系统，解决了从 多个成像系统。我们将开发一种独特的单片光机械设计，将所有 完全没有主动对准的子系统。提出的单视点全景成像系统可以 要么集成到新的结肠镜上，使结肠镜具有标准的前视图，要么360- 度全景侧视图，或作为卡扣式附件构建，用于当前的商业结肠镜 提供360度全景侧视。 为了演示所建议的单视点全景系统的成像能力，我们将首先开发 并对标准结肠镜的单视点全景附着体进行表征，然后评估 在检测息肉方面的表现，并与标准结肠镜进行比较。 拟议的单视点全景成像系统将最大限度地检测息肉，并基本上 降低结肠癌的发病率。它将在五个方面造福于患者和社会：减少 结肠癌，减少患“间歇性”癌症的机会，降低总体发病率和死亡率，增加 结肠镜检查之间的间隔时间，并减轻这种疾病的经济负担。