NSF Convergence Accelerator Track L: Field-Ready Sensing Device for Early-Stage Infectious Diseases

NSF 融合加速器轨道 L：用于早期传染病的现场就绪传感设备

• 批准号: 2344028
• 负责人: Nosang Myung
• 金额: $ 65万
• 依托单位: University of Notre Dame
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2024
• 资助国家: 美国
• 起止时间: 2024-01-15 至 2024-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2344028&HistoricalAwards=false
• 关键词: NSF; Convergence; Accelerator; Track; Field

Human health is strongly linked with the health of animals and our ecosystems. Uncontrolled infectious diseases can devastate animal populations and be transmitted to humans, causing significant socioeconomic disruptions. The COVID-19 pandemic is a recent example of how disease can alter life as we know it on every corner of the planet. It is widely recognized that enhanced surveillance for zoonotic pathogens is foundational to protection of human and animal health, and prevention of the next pandemic. The proposed work will accelerate the development of an affordable intelligent E-nose system capable of using volatile metabolites from animals and humans to identify diseases. We will leverage the use of rapid prototyping and collaboration networks to produce a portable, low-cost, high-performance E-nose device for deployment in various field environments. By doing so, professionals working with animals and humans will be able to identify viral infections in real time, allowing for expeditious interventions to minimize disease transmission. The outcomes of the project will reach beyond the societal impact of the E-nose technology by broadening participation of underrepresented groups in STEM. This project will provide research opportunities for graduate and undergraduate students, K-12 workforce development, public engagement with science, and training of industry professionals. It will be particularly impactful in under-resourced communities where diseases are commonly underdiagnosed. The proposed work will develop a portable and intelligent E-nose system to detect volatile metabolites associated with high consequence infectious diseases in animal and human samples (e.g., feces, urine, and saliva). Our goal for this technology is to accelerate our ability to rapidly detect specific diseases in both individuals and populations, thereby minimizing the time required for responding to and controlling incipient outbreaks of infectious diseases. During Phase I, the sensor system will be fabricated and trained to detect infection by avian influenza viruses, followed by the detection of other infections in domestic and wild animals and humans in Phase II. Diverse sensing data with superior low detection limit will be achieved through defect- and nano-engineering sensing materials. High dimensional sensing data will be collected by individual modulated heating temperature and illumination wavelength and intensity. A machine-learning model will determine the sensitivity value and the profiles for optimum temperature and illumination. Physical and chemical sensor array will be integrated with embedded electronics to reduce the overall Size, Weight, Power and Cost profile. Open-source electronic prototyping platforms will be utilized to achieve rapid prototyping and manufacturing with minimum development cost. The advances proposed by this project will redefine technologies that support the data–information–knowledge pathway and accelerate the process of turning basic measurements into actionable intelligence. This device has practical, life-saving applications that complement conventional approaches to disease prevention and management by providing real-time monitoring.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

人类健康与动物和我们的生态系统的健康密切相关。不受控制的传染病可以摧毁动物种群并传播给人类，造成重大的社会经济混乱。新冠肺炎大流行是一个最近的例子，说明了疾病如何改变我们所知的地球上每个角落的生活。人们普遍认为，加强对人畜共患病病原体的监测是保护人类和动物健康以及预防下一次大流行的基础。拟议的工作将加快开发一种负担得起的智能电子鼻系统，该系统能够使用动物和人类的挥发性代谢物来识别疾病。我们将利用快速原型和协作网络来生产一种便携式、低成本、高性能的电子鼻设备，用于在各种现场环境中部署。通过这样做，从事动物和人类工作的专业人员将能够实时识别病毒感染，从而能够迅速采取干预措施，将疾病传播降至最低。该项目的成果将超越电子鼻技术的社会影响，扩大代表不足的群体在STEM中的参与。该项目将为研究生和本科生提供研究机会、K-12劳动力发展、公众参与科学以及培训行业专业人员。它将在资源不足的社区产生特别的影响，在这些社区，疾病通常被低估。拟议的工作将开发一种便携式和智能电子鼻系统，以检测动物和人类样本(例如粪便、尿液和唾液)中与高后果传染病相关的挥发性代谢物。我们对这项技术的目标是加快我们快速检测个人和人群中特定疾病的能力，从而最大限度地减少应对和控制传染病初期爆发所需的时间。在第一阶段，传感器系统将被制造和训练以检测禽流感病毒的感染，随后在第二阶段将检测家畜、野生动物和人类的其他感染。通过缺陷和纳米工程传感材料将实现具有优越低检测下限的多样化的传感数据。高维传感数据将通过单独调制加热温度和照明波长和强度来收集。机器学习模型将确定敏感值和最佳温度和光照的轮廓。物理和化学传感器阵列将与嵌入式电子设备集成，以降低整体尺寸、重量、功耗和成本。将利用开源电子原型平台，以最低的开发成本实现快速原型和制造。该项目提出的进展将重新定义支持数据-信息-知识途径的技术，并加速将基本测量转化为可操作的情报的进程。该设备具有实用的、挽救生命的应用，通过提供实时监测来补充传统的疾病预防和管理方法。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。