Increasing the Electrophilicity at Boron via Carborane Substituents
通过碳硼烷取代基增加硼的亲电性
基本信息
- 批准号:2349851
- 负责人:
- 金额:$ 57.5万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2024
- 资助国家:美国
- 起止时间:2024-06-01 至 2027-05-31
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
With the support of the Chemical Synthesis program in the Division of Chemistry, Caleb Martin and his research team at Baylor University will study the synthesis of strong boron Lewis acids that feature non-conventional electron withdrawing substituents. Strong Lewis acids are essential to many important catalytic industrial and laboratory processes. Currently, boron compounds that contain fluorine are used in these reactions. However, there are pending Environmental Protection Agency mandates that will restrict the use of fluorine containing reagents that are set to begin 2025. Thus, replacements for the current boron-fluorine catalysts are essential. This project will develop an alternative to fluorine for boron-based catalysts for bond activation chemistry. This project also involves efforts to engage homeless high school students to stimulate their interest in science fields. Additionally, an annual advanced instrumentation workshop will host students and faculty from local small colleges.In this project, the Martin research team will synthesize boranes that feature icosahedral carborane clusters as electron withdrawing groups. A goal is to obtain boranes whose Lewis acidity is enhanced over that of their fluoroaryl counterparts. This enhancement will reflect electronic effects of the carborane substituent as well as the impact of carborane steric profiles upon the Lewis acid properties of these new boron-centered systems. The bulk and Lewis acidity of tris(ortho-carboranyl)borane will be investigated in frustrated Lewis pair chemistry. The other target, bis(1-methyl-ortho-carboranyl)borane, features a highly polar B-H bond. The reactivity of this bond as well as the stability of aryl variants will be studied. The proposed work will investigate the reactivity and properties of the newly synthesized borane Lewis super-acids. If successfully, the development of such new classes of non-fluorine-based boron-centered Lewis acids, could have a broad impact on synthetic and mechanistic chemistry, with implications for sustainable chemistry.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
在化学系化学合成计划的支持下,贝勒大学的Caleb Martin和他的研究团队将研究以非常规吸电子取代基为特征的强硼路易斯酸的合成。强路易斯酸对许多重要的催化工业和实验室过程是必不可少的。目前,在这些反应中使用的是含氟的硼化合物。然而,美国环境保护局(Environmental Protection Agency,简称EPA)仍有一些悬而未决的要求,将从2025年开始限制含氟试剂的使用。因此,替代目前的硼-氟催化剂是必不可少的。该项目将开发一种氟的替代品,用于键活化化学中的硼基催化剂。该项目还包括努力吸引无家可归的高中生,以激发他们对科学领域的兴趣。此外,一年一度的先进仪器工作坊将接待来自当地小型大学的学生和教职员工。在这个项目中,马丁研究小组将合成以二十面体碳硼烷簇合物为电子引出基团的硼烷。一个目标是获得其路易斯酸性比它们的氟芳基对应物更强的硼烷。这一增强将反映碳硼烷取代基的电子效应以及碳硼烷空间构型对这些新的以硼为中心的体系的Lewis酸性质的影响。我们将在受挫的Lewis对化学中研究三(邻位碳硼基)硼烷的本体和Lewis酸性。另一个目标是双(1-甲基邻位碳硼基)硼烷,具有高极性的B-H键。该键的反应性以及芳基变体的稳定性将被研究。这项拟议的工作将研究新合成的硼烷路易斯超强酸的反应性和性质。如果成功,这种以非氟为基础的以硼为中心的刘易斯酸的新类别的开发可能会对合成和机械化学产生广泛的影响,并对可持续化学产生影响。该奖项反映了NSF的法定使命,并通过使用基金会的智力优势和更广泛的影响审查标准进行评估,被认为值得支持。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Caleb Martin其他文献
Caleb Martin的其他文献
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{{ truncateString('Caleb Martin', 18)}}的其他基金
CAREER: Constructing Conjugated Heteroarene Architectures via Ring-Expansion Reactions with Anti-Aromatic Boroles
职业:通过反芳香硼杂环扩环反应构建共轭杂芳烃结构
- 批准号:
1753025 - 财政年份:2018
- 资助金额:
$ 57.5万 - 项目类别:
Continuing Grant