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Profiling Assay for Electrophilicity

Profiling Assay for Electrophilicity
亲电性分析测定
批准号：
10269703
负责人：
Anton Simeonov
金额：
$11.24万
依托单位：
NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/10269703
关键词：
Biological AssayCollaborationsCollectionCommunitiesDetectionExtramural ActivitiesFosteringMorphologic artifactsPharmaceutical ChemistryPublicationsResearchResearch PersonnelTranslationsTriageUnited States National Institutes of HealthWorkbasedesigndrug discoveryhigh throughput screeninghuman diseaseimprovedscreeningsmall moleculesmall molecule librariesvirtual screening

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中文摘要
翻译
在此期间，项目团队致力于优化高通量的检测方法，以筛选这种亲电性分析工作。NCATS早期翻译分支与NIH和校外研究人员建立并保持了110多个积极的合作关系，促进了整个人类疾病谱的药物发现工作。这些努力已经导致了数十个高通量筛选和一些药物化学活动，以进一步改善筛选命中，为我们的合作者和一般研究社区提供出版物和各种有前途的小分子探针和线索。
英文摘要
During this period, the project team worked to optimize a high-throughput amenable assay to enable screening for this electrophilicity profiling effort. The NCATS Early Translation Branch has fostered and maintained over 110 active collaborations with both NIH and extramural investigators, facilitating drug discovery efforts across the entire spectrum of human disease. These efforts have led to dozens of high-throughput screens and a number of medicinal chemistry campaigns to further improve on screening hits, providing our collaborators and the general research community with publications and a variety of promising small molecule probes and leads.
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