Strategy Driven Synthesis of Complex Alkaloids

复杂生物碱的策略驱动合成

• 批准号: 2400232
• 负责人: Thomas Maimone
• 金额: $ 57.5万
• 依托单位: University of California-Berkeley
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2024
• 资助国家: 美国
• 起止时间: 2024-06-01 至 2027-05-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2400232&HistoricalAwards=false
• 关键词: Strategy; Driven; Synthesis; Complex; Alkaloids

With the support of the Chemical Synthesis program in the Division of Chemistry, Professor Thomas Maimone of the University of California, Berkeley will study new synthetic strategies for the construction of complex, nitrogen-containing molecules. At the core of this work is the identification of powerfully simplifying transformations that can lead to the production of topologically unique target molecules with high overall efficiency. The targets chosen for this program challenge the current state-of-the-art in complex molecule synthesis. Results of these endeavors are expected to have a positive impact across the societally important field of organic chemical synthesis which is used to produce medicines, agrochemicals, and materials industrially. This work will also serve as intellectually stimulating training for graduate students who will become future scientists in these fields. Moreover, this grant enables wide-reaching science-focused outreach for Bay Area elementary school students as well as local community college transfer students. Professor Maimone is studying complex alkaloid syntheses of members of the caulamidine and myrmicarin families which have important biological properties and unusual molecular architectures. These biosynthetically mysterious molecules have proven challenging as targets for organic chemical synthesis for many years. Professor Maimone’s work will generate new strategies to construct challenging C–C bond linkages and halogenated Sp3 stereocenters and will also put forth new methods for ring formation using small annulation reagents. This work will not only advance the science of synthesis but allow for the construction of ample quantities of rare natural products for further scientific study. As a part of this project, Professor Maimone is also training his coworkers and preparing them for careers in chemical industries and academia.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

在化学系化学合成项目的支持下，加州大学伯克利分校的托马斯·梅蒙教授将研究构建复杂含氮分子的新合成策略。这项工作的核心是确定有力的简化转换，可以导致生产的拓扑结构独特的目标分子具有高的整体效率。为该计划选择的目标挑战了复杂分子合成的当前最先进水平。这些努力的结果预计将在用于生产药物、农用化学品和工业材料的有机化学合成这一具有社会重要性的领域产生积极影响。这项工作也将作为智力刺激培训的研究生谁将成为未来的科学家在这些领域。此外，这笔赠款使广泛的科学为重点的外展湾区小学生以及当地社区学院转学生。Maimone教授正在研究caulamidine和myrmicarin家族成员的复杂生物碱合成，这些家族具有重要的生物学特性和不寻常的分子结构。多年来，这些生物合成的神秘分子已被证明是有机化学合成的目标。Maimone教授的工作将产生新的策略来构建具有挑战性的C-C键连接和卤代Sp3立体中心，并将提出使用小型成环试剂形成环的新方法。这项工作不仅将推动合成科学的发展，而且还将为进一步的科学研究提供大量的稀有天然产品。作为该项目的一部分，Maimone教授还培训他的同事，并为他们在化学工业和学术界的职业生涯做好准备。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。