Exploring the physical limits of spin systems: A challenge in medical imaging

探索自旋系统的物理极限：医学成像的挑战

• 批准号: 258967444
• 负责人: Professor Dr. Steffen Glaser
• 金额: --
• 依托单位: Laboratoire Interdisciplinaire Carnot de Bourgogne
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2014
• 资助国家: 德国
• 起止时间: 2013-12-31 至 2018-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/258967444?language=en
• 关键词: Exploring; physical; limits; spin; systems

We propose in this project to apply innovative mathematical tools coming from optimal control theory to improve theoretical and experimental techniques in Magnetic Resonance Imaging (MRI) and Nuclear Magnetic Resonance (NMR) spectroscopy. This approach will allow us to explore and to experimentally approach the physical limits of the corresponding spin dynamics in the presence of typical experimental imperfections and limitations. An important goal is the optimization of image contrast and sensitivity for a given measurement time. We will study both fundamental and applied problems of the control of spin systems in MRI and NMR. We anticipate that the proposed techniques will find practical applications in medical imaging in a near future in order to help the medical diagnosis.

在这个项目中，我们建议应用创新的数学工具，从最优控制理论，以提高理论和实验技术在磁共振成像（MRI）和核磁共振（NMR）光谱。这种方法将使我们能够探索和实验方法的物理极限相应的自旋动力学在典型的实验缺陷和限制的存在。一个重要的目标是在给定的测量时间内优化图像对比度和灵敏度。我们将研究磁共振成像和核磁共振中自旋系统控制的基本问题和应用问题。我们预计，所提出的技术将在不久的将来在医学成像中找到实际应用，以帮助医疗诊断。

项目成果

Constant gradient elastography with optimal control RF pulses.

具有最佳控制射频脉冲的恒定梯度弹性成像

• DOI: 10.1016/j.jmr.2018.07.013
• 发表时间: 2018
• 期刊: Journal of magnetic resonance
• 影响因子: 2.2
• 作者: E. Van Reeth;P. Lefebvre;H. Ratiney;S. Lambert;M. Tesch;E. Brusseau;D. Grenier;O. Beuf;S. J. Glaser;D. Sugny;K. Tse-Ve-Koon
• 通讯作者: K. Tse-Ve-Koon

Optimal control theory for applications in Magnetic Resonance Imaging

• DOI: 10.1186/s40736-017-0034-3
• 发表时间: 2017-09
• 期刊: Pacific Journal of Mathematics for Industry
• 作者: Eric Van reeth;H. Ratiney;M. Lapert;S. Glaser;D. Sugny

Discrete-valued-pulse optimal control algorithms: Application to spin systems

• DOI: 10.1103/physreva.92.043417
• 发表时间: 2015-10-22
• 期刊: PHYSICAL REVIEW A
• 影响因子: 2.9
• 作者: Dridi, G.;Lapert, M.;Sugny, D.
• 通讯作者: Sugny, D.

A simplified framework to optimize MRI contrast preparation

• DOI: 10.1002/mrm.27417
• 发表时间: 2019-01-01
• 期刊: MAGNETIC RESONANCE IN MEDICINE
• 影响因子: 3.3
• 作者: Van Reeth，Eric;Ratiney，Helene;Sugny，Dominique
• 通讯作者: Sugny，Dominique

Optimal control design of preparation pulses for contrast optimization in MRI.

MRI 对比度优化的预备脉冲优化控制设计

• DOI: 10.1016/j.jmr.2017.04.012
• 发表时间: 2017
• 期刊: Journal of magnetic resonance
• 影响因子: 2.2
• 作者: E. Van Reeth;H. Ratiney;M. Tesch;D. Grenier;O. Beuf;S. J. Glaser;D. Sugny
• 通讯作者: D. Sugny