I-Corps: Translation Potential of Peptidic Ensembles as Novel Bio-adhesives

I-Corps:肽整体作为新型生物粘合剂的转化潜力

基本信息

  • 批准号:
    2409620
  • 负责人:
  • 金额:
    $ 5万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Standard Grant
  • 财政年份:
    2024
  • 资助国家:
    美国
  • 起止时间:
    2024-03-01 至 2025-02-28
  • 项目状态:
    未结题

项目摘要

The broader impact of this I-Corps project is the development of amino acid-based bio-adhesives. Using low-cost and high throughput strategies, this product demonstrates adhesive properties using a key molecule found in mussel foot proteins which allows mussels to adhere strongly to surfaces in seawater. This technology has the potential to impact the biomedical and bioplastic industry, not only in creating a safer product for the users, but also transforming the way bioplastic materials are manufactured using water instead of petroleum-derived organic solvents which are often highly reactive, flammable, and have health hazards. Finally, since the fundamental properties of the material (e.g., surface specific adhesion and viscosity) are tunable, the bio-adhesive can be used on multiple biological surfaces and used for wound healing, dental fillings, and surgical glues.This I-Corps project utilizes experiential learning coupled with a first-hand investigation of the industry ecosystem to assess the translation potential of the technology. The solution is based on the development of stimuli-responsive peptidic materials and coacervates with modulable internal structure. Enzyme-responsive peptides can be designed to adhere to cell surfaces and peptides with specific sequences can self-assemble and control the kinetics of enzyme responsiveness. Coupled to this, minimalistic peptides can be designed to control the internal structure of coacervates. In this project, peptidic coacervates and enzyme responsive peptides act as adhesives and plasticizers, respectively. As the source materials are biologically-based, the products benefit from biocompatibility and sustainability. The tunability a water-based adhesive with dynamic internal structure allows potential access to a variety of biological surfaces.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
这个i-Corps项目的更广泛影响是氨基酸生物粘合剂的开发。该产品采用低成本和高通量策略,使用贻贝足部蛋白中的一种关键分子展示了粘附性,这种分子使贻贝能够强烈地附着在海水中的表面。这项技术有可能影响生物医学和生物塑料行业,不仅在为用户创造更安全的产品方面,而且还改变了使用水来生产生物塑料材料的方式,而不是使用石油衍生的有机溶剂,因为石油衍生的有机溶剂通常是高活性、易燃和危害健康的。最后,由于材料的基本属性(例如,表面比附着力和粘度)是可调节的,生物粘合剂可以用于多种生物表面,并用于伤口愈合、牙齿填充和外科手术胶。这个i-Corps项目利用经验学习和对行业生态系统的第一手调查来评估该技术的转化潜力。该解决方案基于对刺激反应的多肽材料和具有可调节内部结构的凝聚体的开发。酶反应多肽可以被设计为附着在细胞表面,具有特定序列的多肽可以自组装并控制酶反应的动力学。再加上极简主义的多肽可以被设计成控制凝聚体的内部结构。在本项目中,多肽凝聚体和酶响应多肽分别作为粘合剂和增塑剂。由于来源材料是基于生物的,产品受益于生物兼容性和可持续性。可调性是一种具有动态内部结构的水基粘合剂,可以潜在地接触到各种生物表面。该奖项反映了NSF的法定使命,并通过使用基金会的智力优势和更广泛的影响审查标准进行评估,被认为值得支持。

项目成果

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Ankit Jain其他文献

Unruptured Right Sinus of Valsalva Aneurysm Dissecting into Interventricular Septum Causing Complete Heart Block: Can Early Surgical Correction Revert Rhythm Disturbances?
未破裂的右瓦氏窦动脉瘤切入室间隔导致完全性心脏传导阻滞:早期手术矫正能否恢复心律紊乱?
  • DOI:
    10.4236/wjcd.2018.87034
  • 发表时间:
    2018
  • 期刊:
  • 影响因子:
    0
  • 作者:
    P. Agarwal;Ankit Jain;P. Singh;Harpreet Singh;M. Geelani;V. Mehta
  • 通讯作者:
    V. Mehta
Extensively Metastatic Vaginal Stump Leiomyosarcoma after Total Hysterectomy: A Rare Presentation—A Case Report with Review of Literature
全子宫切除术后广泛转移性阴道残端平滑肌肉瘤:罕见病例报告及文献综述
  • DOI:
  • 发表时间:
    2015
  • 期刊:
  • 影响因子:
    0.4
  • 作者:
    Juhi Singhal;Ankit Jain;A. Saxena;Chandrakanta;Amrita Gupta;Shefali Tyagi;Priyankar Singh
  • 通讯作者:
    Priyankar Singh
Primary Synovial Sarcoma of the Anterior Chest Wall: a Rare Entity at Unusual Location—Case Report
前胸壁原发性滑膜肉瘤:罕见部位的罕见实体 — 病例报告
  • DOI:
    10.1007/s42399-021-00821-7
  • 发表时间:
    2021
  • 期刊:
  • 影响因子:
    0
  • 作者:
    J. Vishnoi;A. Sasidhar;P. Kala;Sudeep Khera;P. Pareek;S. Misra;Ankit Jain
  • 通讯作者:
    Ankit Jain
A Rare Complication of Closed Loop Obstruction with Mesenteric Volvulus Due to Jejunal Diverticulosis—a Case Report
空肠憩室病引起的肠系膜扭转闭环梗阻罕见并发症一例报告
Protein and peptide delivery by chitosan systems
通过壳聚糖系统输送蛋白质和肽
  • DOI:
  • 发表时间:
    2022
  • 期刊:
  • 影响因子:
    0
  • 作者:
    A. Verma;Ankita Tiwari;Shivani Saraf;P. Panda;Ankit Jain;Sanjay K Jain
  • 通讯作者:
    Sanjay K Jain

Ankit Jain的其他文献

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