Diversity of Salinispora actinobacteria producing pharmaceutically relevant natural products from Australian marine sponges

从澳大利亚海绵中生产药用相关天然产物的盐孢放线菌的多样性

• 批准号: LP0882233
• 负责人: Prof John Fuerst
• 金额: $ 6.26万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-03-13 至 2011-07-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP0882233
• 关键词: Diversity; Salinispora; actinobacteria; producing; pharmaceutically

By investigating the distribution of marine microbial resources relevant to drug discovery, we will directly contribute to ARC's Research Priority I - An Environmentally Sustainable Australia Priority Goal and the Priority Goal 'Sustainable use of Australia's biodiversity'. We will determine sources of marine bacteria and their genes useful for discovery of new natural products for treatment of human diseases. We will do this by understanding where new strains of Salinispora bacteria may be isolated and how they are distributed in association with Australian marine sponge fauna, and by determining the distribution and chemical and genetic diversity of novel marine Salinispora bacteria.

通过调查与药物发现相关的海洋微生物资源的分布，我们将直接为ARC的研究优先事项I -环境可持续的澳大利亚优先目标和优先目标“澳大利亚生物多样性的可持续利用”做出贡献。我们将确定海洋细菌及其基因的来源，以发现用于治疗人类疾病的新天然产物。我们将通过了解新的Salinispora细菌菌株可能被分离出来，以及它们如何与澳大利亚海洋海绵动物群相关联，并通过确定新的海洋Salinispora细菌的分布和化学和遗传多样性来实现这一目标。