Molecular Cell Biology and Comparative Genomics Of Planctomycetes and Verrucomicrobia In Relation To Evolution Of Cytoskeletal Proteins and Membrane-bounded Compartments

浮霉菌和疣微菌与细胞骨架蛋白和膜界区室进化相关的分子细胞生物学和比较基因组学

• 批准号: DP0450234
• 负责人: Prof John Fuerst
• 金额: $ 14.62万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2004
• 资助国家: 澳大利亚
• 起止时间: 2004-01-01 至 2006-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0450234
• 关键词: Molecular; Cell; Biology; Comparative; Genomics

Planctomycetes and verrucomicrobia are evolutionarily distinct groups of bacteria which possess unusual cell structure and which share some significant genes important in cell biology with eukaryotes e.g. in verrucomicrobia the cytoskeleton protein tubulin. These bacteria are important for understanding the transition from non-nucleated cells with simple cell division to nucleated cells with chromosome separation via cytoskeletal protein movement.The project will compare genomes of of planctomycetes and verrucomicrobia to determine their relationship, determine whether the tubulin homolog of verrucomicrobia can form cytoskeleton structures, and characterize the cytoskeleton of ammonium-oxidizing planctomycetes used in wastewater treatment.

浮游菌和疣微菌是进化上不同的细菌类群，它们具有不寻常的细胞结构，并且与真核生物共享一些在细胞生物学中重要的基因，例如在疣微菌中的细胞骨架蛋白微管蛋白。这些细菌对于理解从具有简单细胞分裂的无核细胞到通过细胞骨架蛋白运动实现染色体分离的有核细胞的转变非常重要。该项目将比较浮游菌和疣微菌的基因组，以确定它们之间的关系，确定疣微菌的微管蛋白同系物是否可以形成细胞骨架结构，和表征用于废水处理的铵氧化浮游菌的细胞骨架。