Pathogen recognition by taste and odorant receptors and coupling to BALT formation and epithelial remodeling (A06)

通过味觉和气味受体识别病原体并与 BALT 形成和上皮重塑耦合 (A06)

• 批准号: 259628731
• 金额: --
• 依托单位: Institut für Anatomie und Zellbiologie
• 依托单位国家: 德国
• 项目类别: CRC/Transregios
• 财政年份: 2014
• 资助国家: 德国
• 起止时间: 2013-12-31 至 2021-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/259628731?language=en
• 关键词: Pathogen; recognition; taste; odorant; receptors

Specialized chemosensory epithelial cells utilize the canonical taste transduction cascade to recognize bacterial products at the mucosal surface and acutely activate mucociliary clearance through paracrine cholinergic signaling. We will now test our major hypothesis that chemosensory cells (brush and neuroendocrine cells) orchestrate (1) BALT (tertiary lymphoid follicles) formation and (2) infection-induced epithelial remodeling, both via (a) intraepithelial paracrine signaling and (b) modifying innate lymphoid cell (ILC) functions, thereby protecting from or limiting pulmonary infection, utilizing the newly identified murine pathogen B. pseudohinzii as a model organism, and the human pathogen Klebsiella pneumoniae.

专门的化学感受上皮细胞利用经典的味觉转导级联来识别粘膜表面的细菌产物，并通过旁分泌胆碱能信号传导急性激活粘膜纤毛清除。我们现在将测试我们的主要假设，即化学感受细胞（刷状细胞和神经内分泌细胞）协调（1）BALT（三级淋巴滤泡）形成和（2）感染诱导的上皮重塑，两者均通过（a）上皮内旁分泌信号传导和（B）修饰先天淋巴细胞（ILC）功能，从而利用新鉴定的鼠病原体B保护或限制肺部感染。pseudohinzii作为模式生物，以及人类病原体肺炎克雷伯氏菌。