Coordination Funds

我们打算在TP Z中组织活动：(a)协调研究单位使用的动物模型，以实现更好的可比性；(b)提高公众对肌肉骨骼再生在衰老、免疫适应性和机械适应性方面的认识；(c)利用柏林-勃兰登堡再生疗法学院的基础设施，专门为临床科学家（GEROK）建立教育结构；(d)继续开展国际科学联网活动，这些活动是拟议的研究单位的参与者在以前的工作中开展的，目的是强调研究衰老对再生的影响的重要性。为了在人类患者中验证小鼠模型的发现，获得合格的人类血肿是必不可少的。因此，一个特殊的功能将是获取从特定年龄组的骨折患者身上采集的人类血肿。收获将在BCRT核心单元“细胞收获”的帮助下进行协调。所有血肿将被准备好进行分析、储存，并提供给不同的小组，为他们提供人类样本数据，作为研究单元内小鼠模型血肿和组织发现的相关数据。

We intend to structure the activities in the TP Z towards: (a) coordinating the animal models used in the Research Unit to enable better comparability; (b) raising public awareness of musculoskeletal regeneration with respect to aging, immunological fitness and mechanical adaptability; (c) structuring of education by using the infrastructure of the Berlin-Brandenburg School for Regenerative Therapies specifically for clinical scientists (GEROK), and (d) continuation of the international scientific networking activities that have been developed among the participants of the proposed Research Unit during their previous work in order to emphasize the importance of investigating the influence of aging on regeneration. To validate findings from mouse models in human patients, access to qualified human hematomas is essential. Thus a special feature will be the access to harvested human hematoma from fracture patients within specified age groups. The harvesting will be coordinated with the help of the BCRT core unit ¿cell harvest¿. All hematomas will be prepared for analysis, stored and made available for the different groups to provide them with human sample data that serve as correlate to findings in hematoma and tissue of the mouse models within the Research Unit.