Coordination Funds

协调基金

• 批准号: 427459213
• 负责人: Professor Dr. Niels H. Gehring
• 金额: --
• 依托单位: Institut für Genetik
• 依托单位国家: 德国
• 项目类别: Priority Programmes
• 财政年份: 2019
• 资助国家: 德国
• 起止时间: 2018-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/427459213?language=en
• 关键词: Coordination; Funds

Research results of recent years have demonstrated that post-transcriptional processes contribute significantly to the expression of the genetic information. During their lifetime, mRNAs interact with a large number of different trans-acting factors. Because each mRNA is the blueprint for a particular protein and can be bound by a different set of the many mRNA-interacting proteins the resulting ribonucleoprotein particle (mRNP) is believed to be unique in its composition. This implies that the specific set of proteins, non-coding RNAs and other molecules bound to a specific mRNA control its fate and function ("mRNP Code" concept). The composition of mRNPs as a whole and the properties of some RNA-binding proteins have been intensively investigated in recent years. However, there is a lack of knowledge on how the mRNP code manifests itself on individual transcripts and how it is read by the cell. The SPP aims to bring together scientists from different disciplines such as systems biology, biochemistry, structural biology and bioinformatics to decipher the mRNP code. In the coordination project we apply for funds to carry out important central activities of the priority programme, such as workshops and meetings, promotion of national and international visibility, training and support for junior researchers as well as the creation of equal opportunities for female researchers.

近年来的研究结果表明，转录后过程对遗传信息的表达起着重要作用。在它们的生命周期中，mRNA与大量不同的反式作用因子相互作用。因为每个mRNA都是特定蛋白质的蓝图，并且可以被许多mRNA相互作用蛋白质中的不同集合结合，因此认为所产生的核糖核蛋白颗粒（mRNP）的组成是独特的。这意味着与特定mRNA结合的特定蛋白质组、非编码RNA和其他分子控制其命运和功能（“mRNP密码”概念）。近年来，mRNP的整体组成和一些RNA结合蛋白的性质已被深入研究。然而，缺乏关于mRNP代码如何在单个转录本上表现出来以及它如何被细胞读取的知识。SPP旨在汇集来自不同学科的科学家，如系统生物学，生物化学，结构生物学和生物信息学，以破译mRNP代码。在协调项目中，我们申请资金，以开展优先方案的重要核心活动，如讲习班和会议、提高国家和国际知名度、培训和支持初级研究人员以及为女性研究人员创造平等机会。