Compartmentation and Connectivity of the Thalamus: fMRI "Resting State" and DWI Examinations

丘脑的区室和连接性：fMRI“静息状态”和 DWI 检查

• 批准号: 267001568
• 负责人: Professor Dr. Wolfgang Grodd
• 金额: --
• 依托单位: Max-Planck-Institut für biologische Kybernetik
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2015
• 资助国家: 德国
• 起止时间: 2014-12-31 至 2018-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/267001568?language=en
• 关键词: Compartmentation; Connectivity; Thalamus; fMRI; Resting

The human thalamus in terms of its internal parcellation, its connectivity patterns, the functioning of its circuitry, and its relationship to the cerebral cortex, still partly constitutes a terra incognita. Almost all information processing in cortex strongly depends on the thalamic interactions. Therefore, the knowledge of thalamic connections and interconnections is important to understand cortical functions. Although changes in the thalamus play a prominent role in the functionally defined pathophysiology of psychiatric and neurodegenerative diseases, its internal structures are largely identified and delineated based on structural cytoarchitectonic postmortem atlases, which are used for localization of neuro- or radiosurgical interventions. As such, there is an urgent need to understand the functional and structural subdivisions of the thalamus in vivo and provide a valid map for scientific and clinical studies. The objective of our study is to examine the subdivisions of the thalamus and determine its cortical connectivity pattern by the use of resting state fMRI (rsfMRI) and diffusion weighted imaging (DWI). First, we want to provide an in vivo segmentation of the human thalamus, which can be used for the analysis and interpretation of imaging findings in the clinical neurosciences. Secondly, this compartmentation will be analyzed in respect to its connectivity with cortical structures by means of correlation analysis and fiber tracking (FT). In addition, specific hemispheric and gender differences will be characterized in terms of the ensuing segmentations. Finally, in a third step, the functional and structural segmentation of the thalamus will be compared and related to the existing anatomical atlases. Overall, we hope that this project will enhance our understanding of the role of the thalamus in concert with the sensory and cognitive functions of the brain.

人类丘脑的内部包裹、连接模式、回路功能以及与大脑皮层的关系，仍然部分地构成了一个未知领域。几乎所有的信息处理都强烈依赖于丘脑的相互作用。因此，丘脑连接和互连的知识是重要的，以了解皮质功能。虽然丘脑的变化在精神病和神经退行性疾病的功能定义的病理生理学中起着重要作用，但其内部结构主要是基于结构细胞结构死后图谱来识别和描绘的，该图谱用于神经或放射外科干预的定位。因此，迫切需要了解体内丘脑的功能和结构细分，并为科学和临床研究提供有效的地图。本研究的目的是通过静息态功能磁共振成像（rsfMRI）和弥散加权成像（DWI）检查丘脑的分区，并确定其皮质连接模式。首先，我们想提供一个在体内分割的人丘脑，它可以用于分析和解释的临床神经科学的成像结果。其次，通过相关性分析和纤维追踪（FT）分析这种区室化与皮质结构的连接性。此外，具体的半球和性别差异将在随后的分割方面的特点。最后，在第三步中，丘脑的功能和结构分割将与现有的解剖图谱进行比较和相关。总的来说，我们希望这个项目将增强我们对丘脑与大脑的感觉和认知功能的作用的理解。

项目成果

Functional parcellation using time courses of instantaneous connectivity

• DOI: 10.1016/j.neuroimage.2017.07.027
• 发表时间: 2017-07
• 期刊: NeuroImage
• 影响因子: 5.7
• 作者: E. V. Oort;M. Mennes;T. Schröder;V. Kumar;N. I. Z. Jimenez;W. Grodd;Christian F. Doeller;C. Beckmann-C.-B

In-vivo quantitative structural imaging of the human midbrain and the superior colliculus at 9.4T

• DOI: 10.1016/j.neuroimage.2018.04.071
• 发表时间: 2018-08-15
• 期刊: NEUROIMAGE
• 影响因子: 5.7
• 作者: Loureiro, Joana R.;Himmelbach, Marc;Hagberg, Gisela E.
• 通讯作者: Hagberg, Gisela E.

Direct diffusion-based parcellation of the human thalamus

• DOI: 10.1007/s00429-014-0748-2
• 发表时间: 2015-05-01
• 期刊: BRAIN STRUCTURE & FUNCTION
• 影响因子: 3.1
• 作者: Kumar, Vinod;Mang, Sarah;Grodd, Wolfgang
• 通讯作者: Grodd, Wolfgang

Functional anatomy of the human thalamus at rest

• DOI: 10.1016/j.neuroimage.2016.12.071
• 发表时间: 2017-02-15
• 期刊: NEUROIMAGE
• 影响因子: 5.7
• 作者: Kumar, Vinod Jangir;van Oort, Erik;Grodd, Wolfgang
• 通讯作者: Grodd, Wolfgang