The effect of synaptic short-term plasticity on granule cell activity in the dentate gyrus microcircuit (A02)

突触短期可塑性对齿状回微电路中颗粒细胞活性的影响（A02）

• 批准号: 267458737
• 金额: --
• 依托单位: Deutsches Krebsforschungszentrum (DKFZ)
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2015
• 资助国家: 德国
• 起止时间: 2014-12-31 至 2018-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/267458737?language=en
• 关键词: effect; synaptic; short; term; plasticity

Odors are represented in the olfactory bulb by spatiotemporal patterns of multiple glomeruli, corresponding to ensembles of active Mitral cells. Different, yet similar odors share active Mitral cells, resulting in overlapping patternsIt has been hypothesized that GABAergic cells play a central role for decorrelation of similar activity patterns in the OB. In this project, we will analyse by in vivo calcium-imaging of Mitral cells activity and by behavioural testing how GABAergic periglomerular cells influence ensemble activity and odor discrimination.

气味通过多个肾小球的时空模式在嗅球中表现出来，与活跃的二尖瓣细胞的集合相对应。不同但相似的气味共享活跃的二尖瓣细胞，导致重叠模式。有人假设，gaba能细胞在OB中类似活动模式的去相关性中发挥核心作用。在这个项目中，我们将通过体内二尖瓣细胞活性的钙成像和行为测试来分析gaba能的肾小球周围细胞如何影响集合活性和气味辨别。