Structural and functional diversity of the axon initial segment of principal neurons in hippocampal ensembles. (A03)

海马体中主要神经元轴突初始段的结构和功能多样性。

• 批准号: 267465262
• 金额: --
• 依托单位: Abteilung Neuro- und Sinnesphysiologie
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2015
• 资助国家: 德国
• 起止时间: 2014-12-31 至 2018-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/267465262?language=en
• 关键词: Structural; functional; diversity; axon; initial

Axon-carrying dendrites (AcDs) constitute a privileged channel for excitatory synaptic input in a subset of hippocampal pyramidal cells. We could show that AcD and nonAcD cells are differently recruited into functional ensembles and hypothesize that the privileged input channel can additionally be dynamically regulated by different functional states (i.e. network oscillations). In this context we want to test how AcDs are developed during corticogenesis, how they are innervated by specific excitatory and inhibitory inputs, and whether they remain structurally and functionally plastic throughout life. Thus, we anticipate contributing to important questions on how cellular mechanisms determine state- and experience-dependent formation of ensembles.

轴突携带树突（AcDs）在海马锥体细胞亚群中构成兴奋性突触输入的特权通道。我们可以证明AcD和非AcD细胞被不同地招募到功能集合体中，并假设特权输入通道可以通过不同的功能状态（即网络振荡）进行动态调节。在这种情况下，我们想要测试皮质发生过程中AcDs是如何发展的，它们是如何被特定的兴奋性和抑制性输入所支配的，以及它们是否在一生中保持结构和功能上的可塑性。因此，我们期望对细胞机制如何决定状态和经验依赖的组合形成的重要问题做出贡献。