A self-consistent theory of non-specific and specific interactions of membranes and vesicles with hard, soft polymeric, and fluctuating substrates

膜和囊泡与硬、软聚合物和波动基质的非特异性和特异性相互作用的自洽理论

• 批准号: 26845722
• 负责人: Professor Dr. Udo Seifert
• 金额: --
• 依托单位: II. Institut für Theoretische Physik
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2006
• 资助国家: 德国
• 起止时间: 2005-12-31 至 2009-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/26845722?language=en
• 关键词: self; consistent; theory; non; specific

Our aim is to provide a quantitative theoretical framework for the problem of adhesion and de-adhesion of fluctuating lipid membranes and vesicles interacting with different types of substrates. This will be achieved by constructing a self-consistent theory for the effective potential of interactions that includes the temperature-dependent fluctuations which renormalize the direct interactions. For vesicles, the relation between the tension, geometrical constraints, and the shape will have to be determined. We will consider the interaction with (i) hard substrates that exhibit complex direct interactions (ii) soft compressible substrates that are analogous to a thick layer of polymers, (iii) \substrates which consist of a fluctuating bilayer connected to the other membrane with an array of elastic springs and (iv) elastic fluctuating substrates. Using the concept of an effective adhesion or repulsion strength, we will model discrete interactions, taking into account the statistical nature of the ensemble and of the single bond. Direct collaboration with several groups where the relevant measurements are currently performed will enable the comparison with appropriate experimental data.

我们的目的是为波动的脂质膜和囊泡与不同类型的底物相互作用的粘附和去粘附问题提供一个定量的理论框架。这将通过构建一个相互作用有效势的自洽理论来实现，该理论包括使直接相互作用重归一化的温度相关波动。对于囊泡，必须确定张力、几何约束和形状之间的关系。我们将考虑与(i)表现出复杂直接相互作用的硬底物（ii）类似于厚聚合物层的软可压缩底物，（iii）由带有弹性弹簧阵列的与另一膜连接的波动双层组成的底物和（iv）弹性波动底物的相互作用。利用有效粘附或排斥强度的概念，我们将模拟离散相互作用，考虑到集合和单键的统计性质。与目前正在进行相关测量的几个小组直接合作，将能够与适当的实验数据进行比较。

项目成果

Coexistence of dilute and densely packed domains of ligand-receptor bonds in membrane adhesion

• DOI: 10.1209/0295-5075/99/38003
• 发表时间: 2012-08-01
• 期刊: EPL
• 影响因子: 1.8
• 作者: Schmidt, Daniel;Bihr, Timo;Smith, Ana-Suncana
• 通讯作者: Smith, Ana-Suncana