Mechanisms of interleukin-6 action in trauma-induced impairment of bone regeneration (C01)

本课题研究白细胞介素-6（IL-6）在创伤性骨折愈合中的作用。我们首次表明IL-6反式信号传导对于常规愈合不是必需的，但介导创伤诱导的受损骨修复，因为其选择性抑制导致显著改善骨愈合。相比之下，IL-6经典信号传导诱导促再生效应。我们现在将进一步阐明IL-6在骨愈合中的相关机制，重点是中性粒细胞和肥大细胞，它们在骨损伤后充当细胞防御的第一道防线，并且可能是IL-6信号传导的效应细胞和/或靶细胞。

This project studies the function of interleukin-6 (IL-6) in trauma-induced compromised bone fracture healing. We showed for the first time that IL-6 trans-signaling is non-essential for regular healing, but mediates trauma-induced compromised bone repair, as its selective inhibition led to significantly improved bone healing. By contrast, IL-6 classic signaling induces pro-regenerative effects. We will now further elucidate IL-6-related mechanisms in bone healing with a focus on neutrophils and mast cells, which act as the first line of cellular defense after bone injury and may be the effector and/or target cells of IL-6 signaling.