Extracellular matrix after acute cardiac ischemia: Mechanisms of hyaluronan-mediated protection (A08)

急性心肌缺血后的细胞外基质：透明质酸介导的保护机制（A08）

• 批准号: 269665103
• 金额: --
• 依托单位: Institut für Pharmakologie
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2015
• 资助国家: 德国
• 起止时间: 2014-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/269665103?language=en
• 关键词: Extracellular; matrix; after; acute; cardiac

The project aims to deepen the mechanistic understanding of the beneficial effects of hyaluronan (HA) matrix in cardiac ischemia. Therefore, the role of RHAMM (receptor of HA-mediated motility) will be unraveled using transgenic mice. It will be tested whether further increase of local HA/HA-signaling post-I/R by either deletion of hyaluronidases 1/-2 or overexpression of HA-synthase 2 will improve cardiac function. Furthermore, we ask whether the healing response post-I/R in T2DM is interrelated with cardiac HA synthesis. Finally, chemical exchange saturation transfer imaging will be applied to monitor early cardiac HA in large animals as a potential biomarker.

该项目旨在加深对透明质酸（HA）基质在心肌缺血中的有益作用的机制理解。因此，RHAMM（HA介导的运动受体）的作用将使用转基因小鼠来阐明。将测试通过缺失透明质酸酶1/-2或HA合酶2的过表达来进一步增加I/R后局部HA/HA信号传导是否会改善心脏功能。此外，我们还想知道T2 DM I/R后的愈合反应是否与心脏HA合成相关。最后，化学交换饱和转移成像将作为一种潜在的生物标志物应用于监测大型动物的早期心脏HA。