Molecular basis of antigen recognition by variable lymphocyte receptors (VLRs) (P27*)

可变淋巴细胞受体 (VLR) 识别抗原的分子基础 (P27*)

• 批准号: 269890148
• 金额: --
• 依托单位: Max-Planck-Institut für Immunbiologie und Epigenetik
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2015
• 资助国家: 德国
• 起止时间: 2014-12-31 至 2017-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/269890148?language=en
• 关键词: Molecular; basis; antigen; recognition; variable

The variable lymphocyte antigen receptor type C (VLRC) of lamprey T cells consists of repetitive arrays of leucine-rich repeat (LRR) modules. Our recent work provided evidence for selection of functional VLRC receptors with respect to the number of LRR modules in VLRC molecules and the sequence diversity of the N-terminal LRR1 domain. Biochemical characterization of candidate polymorphic interaction molecules of VLRC antigen receptors and the structure of the VLRC signaling complex, with particular reference to the biochemical characterization of the dynamics of these complexes, is expected to yield unprecedented insight into the alternative adaptive immune system of lampreys.

Lamprey T细胞的可变C型淋巴细胞抗原受体(VLRC)由富含亮氨酸的重复序列(LRR)模块组成。我们最近的工作为从VLRC分子中LRR模块的数量和N端LRR1结构域的序列多样性来选择具有功能的VLRC受体提供了证据。对VLRC抗原受体候选多态相互作用分子和VLRC信号复合体结构的生化表征，特别是对这些复合体动力学的生化表征，有望对七鳃鳗替代适应性免疫系统产生前所未有的洞察。