Determination of pore size distributions using twofold diffusion-weighted magnetic resonance imaging

使用双扩散加权磁共振成像测定孔径分布

• 批准号: 269902106
• 负责人: Professor Dr. Martin A. Koch
• 金额: --
• 依托单位: Institut für Medizintechnik (IMT)
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2015
• 资助国家: 德国
• 起止时间: 2014-12-31 至 2019-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/269902106?language=en
• 关键词: Determination; pore; size; distributions; using

Pathological processes can modify the microscopic structure of biological tissue. A number of methods for detecting and investigating such changes is based on measuring diffusion of water molecules in the tissue. Thermal energy causes the molecules to move randomly in and around the cells. This diffusion motion is hindered or restricted by the cell membranes. The characteristics of water diffusion hence reflects the tissue structure. Magnetic resonance imaging can be used to measure the characteristics of water diffusion noninvasively. Here, the measured signal is diffusion weighted by magnetic fields that linearly depend on position. Double diffusion weighting is a relatively new approach to assessing the mean cell size and shape. The difference between signals acquired with parallel or antiparallel field gradients is a measure of pore or cell size. When the delay between the two weightings is increased, this difference decreases. In this project, the shape of the decrease is exploited to obtain the distribution function of pore sizes, instead of a mean pore size. In another part of the project it is investigated whether the effects exploited in the proposed method need to be considered in measurements of the cell membrane permeability. Such measurements also apply double diffusion weighting.

病理过程可以改变生物组织的微观结构。许多检测和研究这种变化的方法都是基于测量水分子在组织中的扩散。热能使分子在细胞内和细胞周围随机移动。这种扩散运动受到细胞膜的阻碍或限制。因此，水扩散的特性反映了组织结构。磁共振成像可用于测量水扩散的特性，无创。这里，测量的信号通过线性依赖于位置的磁场进行扩散加权。双扩散加权是一种相对较新的评估平均细胞大小和形状的方法。用平行或反平行场梯度获得的信号之间的差异是孔或细胞大小的量度。当两个权重之间的延迟增加时，该差异减小。在这个项目中，减少的形状被用来获得孔径的分布函数，而不是平均孔径。在该项目的另一部分中，研究了在测量细胞膜渗透性时是否需要考虑所提出的方法中利用的影响。这样的测量也应用双扩散加权。