Interfacial effects and ingrowing behavior of magnesium-based foams as bioresorbable bone substitue material

镁基合金作为可吸收植入物用于骨内固定仍是国内外研究小组关注的焦点。以往的体外和体内研究表明，该材料具有良好的生物相容性。此外，还表明不同的合金成分对腐蚀过程有影响。该方案的目的是研究一种可生物降解的骨替代物，它基于具有(两种不同)开放的多孔几何结构和三种不同涂层的LAE442-和镁La2合金。支架将在未加载和加载的松质骨中进行测试。将深入研究镁支架、涂层和宿主组织之间的相互作用与生物力学、生物相容性和降解的关系。此外，将评估骨替代物内的细胞反应，并对新骨形成进行组织形态计量学检查。根据这些研究的结果，将对种植体结构进行修改。最初，这些研究将在已建立的兔子模型中进行，以获得初步结果。在这些发现的基础上，在优化所有实验设置后，将在代表人骨的绵羊模型中进行进一步的研究。

Magnesium-based alloys as absorbable implants for osteosynthesis are still in the focus of national and international research groups. Previous in vitro and in vivo studies demonstrated good biocompatibility. Furthermore, it has been shown that individual alloy compositions have an influence on the corrosion process. The aim of this proposal is, to study a biodegradable bone substitute based on LAE442- and MgLa2 alloys with (two different) open porous geometries and three different coatings. The scaffolds will be tested in the non-loaded and in the loaded cancellous bone. The interactions between Mg-scaffolds, coatings and host tissue in relation to biomechanics, biocompatibility and degradation will be thoroughly investigated. Furthermore, the cellular reactions within the bone substitutes will be evaluated and new bone formation will be examined histomorphometrically. Based on the results of these studies, the implant structure will be modified. Initially, these studies will be executed in an established rabbit model to obtain preliminary results. Based on those findings and after optimization of all experimental settings, additional studies will be carried out in a sheep model representative for human bone.