Interfacial effects and ingrowing behavior of magnesium-based foams as bioresorbable bone substitue material

镁基合金作为可吸收性骨植入物一直是国内外研究的热点。先前的体外和体内研究表明其具有良好的生物相容性。此外，还表明了不同合金成分对腐蚀过程的影响。本提案的目的是研究一种基于LAE442-和MgLa2合金的可生物降解骨替代品，具有（两种不同的）开放多孔几何形状和三种不同的涂层。支架将在无载荷和有载荷的松质骨中进行测试。mg -支架、涂层和宿主组织之间的相互作用与生物力学、生物相容性和降解的关系将被深入研究。此外，将评估骨替代物内的细胞反应，并从组织形态学上检查新骨的形成。根据这些研究的结果，种植体的结构将被修改。首先，这些研究将在一个已建立的兔子模型中进行，以获得初步结果。在这些发现的基础上，在优化所有实验设置后，将在具有代表性的人骨羊模型中进行进一步的研究。

Magnesium-based alloys as absorbable implants for osteosynthesis are still in the focus of national and international research groups. Previous in vitro and in vivo studies demonstrated good biocompatibility. Furthermore, it has been shown that individual alloy compositions have an influence on the corrosion process. The aim of this proposal is, to study a biodegradable bone substitute based on LAE442- and MgLa2 alloys with (two different) open porous geometries and three different coatings. The scaffolds will be tested in the non-loaded and in the loaded cancellous bone. The interactions between Mg-scaffolds, coatings and host tissue in relation to biomechanics, biocompatibility and degradation will be thoroughly investigated. Furthermore, the cellular reactions within the bone substitutes will be evaluated and new bone formation will be examined histomorphometrically. Based on the results of these studies, the implant structure will be modified. Initially, these studies will be executed in an established rabbit model to obtain preliminary results. Based on those findings and after optimization of all experimental settings, additional studies will be carried out in a sheep model representative for human bone.