Interfacial effects and ingrowing behavior of magnesium-based foams as bioresorbable bone substitue material

镁基合金作为可吸收性骨接合植入物仍是国内外研究的热点。先前的体外和体内研究证明了良好的生物相容性。此外，已经表明，个别合金成分对腐蚀过程有影响。该提案的目的是研究基于LAE442和MgLa2合金的生物可降解骨替代物，该合金具有（两种不同的）开孔几何形状和三种不同的涂层。将在未加载和加载的松质骨中测试支架。镁支架，涂层和宿主组织之间的相互作用与生物力学，生物相容性和降解将进行彻底研究。此外，将评价骨替代品内的细胞反应，并通过组织形态计量学检查新骨形成。根据这些研究的结果，将修改植入物结构。最初，这些研究将在已建立的家兔模型中进行，以获得初步结果。基于这些发现，在优化所有实验设置后，将在代表人骨的绵羊模型中进行额外研究。

Magnesium-based alloys as absorbable implants for osteosynthesis are still in the focus of national and international research groups. Previous in vitro and in vivo studies demonstrated good biocompatibility. Furthermore, it has been shown that individual alloy compositions have an influence on the corrosion process. The aim of this proposal is, to study a biodegradable bone substitute based on LAE442- and MgLa2 alloys with (two different) open porous geometries and three different coatings. The scaffolds will be tested in the non-loaded and in the loaded cancellous bone. The interactions between Mg-scaffolds, coatings and host tissue in relation to biomechanics, biocompatibility and degradation will be thoroughly investigated. Furthermore, the cellular reactions within the bone substitutes will be evaluated and new bone formation will be examined histomorphometrically. Based on the results of these studies, the implant structure will be modified. Initially, these studies will be executed in an established rabbit model to obtain preliminary results. Based on those findings and after optimization of all experimental settings, additional studies will be carried out in a sheep model representative for human bone.