Spatio-temporal modelling of Ras dependent MAP kinase activation

该项目是国家重点研究项目“建设和改造澳大利亚工业的前沿技术”的核心。利用系统生物学的前沿方法和技术，结合创新的实验分子细胞生物学，我们将构建和模拟EGF调节的MAP激酶途径的数学模型。该项目将对驱动细胞分裂、分化和转化的细胞信号转导的基本机制产生新的见解，并可能使新的抗癌疗法的设计成为可能。重要的是，该项目开发的建模和模拟方法将普遍适用于其他复杂系统，如可持续生态系统。

This project is at the heart of the national research priority 'Frontier Technologies for Building and Transforming Australian Industries'. Using cutting edge methods and techniques of systems biology, coupled with innovative experimental molecular cell biology we will construct and simulate mathematical models of the EGF-regulated MAP kinase pathway. The project will yield new insights into the fundamental mechanisms of cell signal transduction that drive cell division, differentiation and transformation and may enable the design of new anticancer therapies. Importantly, the modelling and simulation methods developed in the project will have a general applicability to other complex systems such as sustainable ecological systems.