GRK 754: Myocardial Gene Expression und Function - Myocardial Hypertrophy

心力衰竭是所有西方社会中最突出的心脏问题之一。在大多数情况下，心肌肥厚是在高血压或心肌梗死后心脏超负荷后发展起来的，通常与老年有关。机械过载导致受影响心肌的生长反应增强，其中包括心肌基因表达的变化。在肥厚发展后的不同时间间隔，肥厚的心肌会发生重构和收缩衰竭。这种发育的生理和分子基础尚不清楚；基因决定因素可能起到一定作用。研究性训练组的研究目的是阐明导致心肌肥厚及其向心力衰竭转变的生理、生化和遗传机制。对这些机制的更好理解将创造新的治疗选择。

Heart failure represents one of the most prominent cardiac problems of all western societies. In most cases it is preceded by myocardial hypertrophy which develops following cardiac overload in hypertension or after myocardial infarction and is frequently associated with old age. Mechanical overload leads to an augmented growth response of the affected cardiac muscle which includes changes in myocardial gene expression. In varying time intervals after development of hypertrophy, remodeling and contractile failure of the hypertrophied myocardium result. The physiological and molecular basis of this development are as yet unclear';' genetic determinants probably play a role. The research aim of the research training grouop is to elucidate the physiological, biochemical and genetic mechanisms that lead to myocardial hypertrophy and its transition into cardiac failure. Better understanding of these mechanisms will create new therapeutic options.