Self-deactivating biocidal polymers

抗生素和杀菌剂的使用已经达到了很大的规模，这些物质的使用往往没有任何的影响。环境中抗菌活性化合物的积累会导致不可预测的长期问题。该项目的目标是开发一种具有广泛杀伤谱的杀菌剂无毒聚合物，当它进入环境后，在最初使用后的预期时间内自行失活。功能性聚（2-甲基氯唑啉）等生物杀灭聚合物有望满足相应的要求。它们具有生物相容性，无毒，并且可以从初步工作中获得令人满意的初步结果，其中可以使用特殊的端基效应（卫星基效应）来影响这些聚合物的生物杀灭活性。因此，在本项目中，我们将重点合成基于2-乙基、2-npropyl和2-异丙基-2-恶唑啉的新型杀菌剂同源共聚物和共聚物，并具有新的功能性杀菌剂和可切割的卫星端基，以提高抗菌活性，并建立不同失活时间的聚合物组合。

The use of antibiotics and biocides has reached a large scale, often these substances are used without any concern for the effects. The accumulation of the antimicrobial active compounds in the environment leads to unpredictable long term problems. The goal of this project is the development of a biocidal non-toxic polymer with a broad killing spectrum, which will be self-deactivated in a desired timeframe after its initial use when it gets in the environment. Biocidal polymers such as functional poly(2-methyloxazoline)s were found to be promising candidates to meet the corresponding requirements. They are biocompatible, non-toxic and first satisfactory results could be acquired from preliminary work, in which a special endgroup effect (satellite group effect) can be used to influence the biocidal activity of these polymers. Thus, in this project we will focus on the synthesis of novel biocidal homo- and copolymers based on 2-ethyl-, 2-npropyl and 2-isopropyl-2-oxazolines, with new functional biocidal and cleavable satellite endgroups in order to enhance the antimicrobial activity and to establish a portfolio of polymers with different deactivation times.