Self-deactivating biocidal polymers

自失活杀菌聚合物

• 批准号: 273585134
• 负责人: Dr. Christian Krumm
• 金额: --
• 依托单位: Lehrstuhl für Biomaterialien und Polymerwissenschaften (BMP)
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2015
• 资助国家: 德国
• 起止时间: 2014-12-31 至 2016-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/273585134?language=en
• 关键词: Self; deactivating; biocidal; polymers

The use of antibiotics and biocides has reached a large scale, often these substances are used without any concern for the effects. The accumulation of the antimicrobial active compounds in the environment leads to unpredictable long term problems. The goal of this project is the development of a biocidal non-toxic polymer with a broad killing spectrum, which will be self-deactivated in a desired timeframe after its initial use when it gets in the environment. Biocidal polymers such as functional poly(2-methyloxazoline)s were found to be promising candidates to meet the corresponding requirements. They are biocompatible, non-toxic and first satisfactory results could be acquired from preliminary work, in which a special endgroup effect (satellite group effect) can be used to influence the biocidal activity of these polymers. Thus, in this project we will focus on the synthesis of novel biocidal homo- and copolymers based on 2-ethyl-, 2-npropyl and 2-isopropyl-2-oxazolines, with new functional biocidal and cleavable satellite endgroups in order to enhance the antimicrobial activity and to establish a portfolio of polymers with different deactivation times.

抗生素和杀生物剂的使用已经达到了大规模，通常这些物质的使用没有任何影响的关注。抗微生物活性化合物在环境中的积累导致不可预测的长期问题。该项目的目标是开发一种具有广泛杀伤谱的生物杀灭无毒聚合物，当它进入环境时，它将在初始使用后的所需时间内自行失活。生物杀灭聚合物，如功能性聚（2-甲基恶唑啉）被认为是有前途的候选人，以满足相应的要求。它们是生物相容的，无毒的和第一个令人满意的结果，可以从初步的工作，其中一个特殊的端基效应（卫星基团效应）可以用来影响这些聚合物的生物杀灭活性，可以获得。因此，在这个项目中，我们将专注于合成新的生物杀灭剂均聚物和共聚物的基础上2-乙基，2-正丙基和2-异丙基-2-恶唑啉，新的功能性生物杀灭剂和可裂解的卫星端基，以提高抗微生物活性，并建立一个投资组合的聚合物具有不同的失活时间。

项目成果

Highly active and selective telechelic antimicrobial poly(2-oxazoline) copolymers

• DOI: 10.1016/j.polymer.2017.04.074
• 发表时间: 2017-06-02
• 期刊: POLYMER
• 影响因子: 4.6
• 作者: Krumm, Christian;Hijazi, Montasser;Tiller, Joerg C.
• 通讯作者: Tiller, Joerg C.

Chapter 15:Antimicrobial Polymers and Surfaces – Natural Mimics or Surpassing Nature?

第 15 章：抗菌聚合物和表面——模仿自然还是超越自然？

• DOI: 10.1039/9781782626664-00490
• 发表时间: 2017
• 作者: C. Krumm;J. C. Tiller
• 通讯作者: J. C. Tiller

Telechelic, Antimicrobial Hydrophilic Polycations with Two Modes of Action.

具有两种作用模式的遥爪抗菌亲水聚阳离子

• DOI: 10.1002/mabi.201700389
• 发表时间: 2018
• 期刊: Macromolecular bioscience
• 影响因子: 4.6
• 作者: L. Richter;M. Hijazi;F. Arfeen;C. Krumm;J.C. Tiller
• 通讯作者: J.C. Tiller