Immune complex mediated and IgG Fc receptor-dependent recruitment of leukocytes into the skin (C02+)

免疫球蛋白形成的免疫复合体及其随后与Fc受体的结合对于诱导皮肤保护性体液免疫反应具有重要意义。免疫复合体具有重要的免疫调节特性。我们的研究表明，免疫复合体与激活表达Fcγ的白细胞的定向迁移有关。使用不同的Fcγ受体缺陷白细胞和体内感染和自身免疫模型，我们将研究免疫复合物在皮肤中定向迁移的免疫学相关性和分子机制。

The formation of immune complexes by immunglobulins and their subsequent binding to Fc-receptors is of central relevance for the induction of protective humoral immune responses in the skin. Immune complexes have important immunoregulatory properties. Our studies demonstrate the relevance of immune complexes for activating a directed migration of Fcγ-expressing leukocytes. Using different Fcγ-receptor deficient leukocytes and in vivo infection- and autoimmune models, we will study the immunologic relevance and the molecular mechanisms of immune complex-directed migration in skin.